A5042069371- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Mesenchymal stem cell research
- Heat shock proteins research
- Bone and Joint Diseases
- Musculoskeletal synovial abnormalities and treatments
- Protein Degradation and Inhibitors
- Renal Transplantation Outcomes and Treatments
- Orthopedic Surgery and Rehabilitation
- Microtubule and mitosis dynamics
- Renal and Vascular Pathologies
- Liver physiology and pathology
- Tendon Structure and Treatment
- Organ Transplantation Techniques and Outcomes
- Organ Donation and Transplantation
Imam Khomeini Hospital
2019-2023
Tehran University of Medical Sciences
2020-2023
Iran University of Medical Sciences
2019
Kerman University of Medical Sciences
2014
Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have been widely reported as promising cell-free products that show therapeutic effects of the parental but not their limitations. Due to intrinsic liver tropism MSC-EVs, they used therapeutics or drug carriers for treatment diseases. However, rapid clearance target site may attenuate efficiency systemically administered MSC-EVs. Herein, sustained release into peritoneum has proposed a new strategy prolong bioavailability...
Various somatic tissue‐derived mesenchymal stromal cells (MSCs) have been considered as an attractive therapeutic tool for treatment of liver diseases in which the secretion soluble factors or extracellular vesicles (EVs) is most probable mechanism. The experimental application human embryonic stem cell‐derived MSC (ES‐MSC) increased rapidly and showed promising results, vitro vivo. However, possible effects ES‐MSC their EVs on Thioacetamide (TAA)‐induced chronic injury not evaluated yet....
Natural killer (NK) cell therapy is one of the most promising treatments for Glioblastoma Multiforme (GBM). However, this emerging technology limited by availability sufficient numbers fully functional cells. Here, we investigated efficacy NK cells that were expanded and treated interleukin-2 (IL-2) heat shock protein 70 (HSP70), both in vitro vivo. Proliferation cytotoxicity assays used to assess functionality vitro, after which naïve administrated intracranially systemically compare...
Abstract Glioblastoma multiforme (GBM) is a unique aggressive tumor and mostly develops in the brain, while rarely spreading out of central nervous system. It associated with high mortality rate; despite tremendous efforts having been made for effective therapy, recurrence occurs prevalence. To elucidate mechanisms that lead to new drug discovery, animal models progression one oldest most beneficial approaches not only investigating nature tumor, but also improving preclinical research....
Natural killer (NK) cell therapy is one of the most promising treatments for Glioblastoma Multiforme (GBM). However, this emerging technology limited by availability sufficient numbers fully functional cells. Here, we investigated efficacy NK cells that were expanded and treated interleukin-2 (IL-2) heat shock protein70 (HSP70), both in vitro vivo. Proliferation cytotoxicity assays used to assess functionality vitro, after which naïve administrated intra-cranially systemically...
To date, there has been little agreement on the use of ultrasonographic parameters in predicting long-term outcome after transplantation. This study evaluates whether ultrasonography graft performed early stage transplantation is a valuable predictor for long-term-outcome.The aim this was to evaluate association (resistive index [RI], pulsatility index[PI], end diastolic velocity [EDV], length and parenchymal volume) measured within first week with 6 months function.A cross-sectional 91 (46...