A5100676446- Blood groups and transfusion
- Hemoglobinopathies and Related Disorders
- Blood transfusion and management
- Neonatal Health and Biochemistry
- Blood donation and transfusion practices
- Thermal Regulation in Medicine
- Prostate Cancer Treatment and Research
- T-cell and B-cell Immunology
- Systemic Lupus Erythematosus Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Cardiac Arrest and Resuscitation
- Shoulder Injury and Treatment
- Organ Transplantation Techniques and Outcomes
- Infection Control and Ventilation
- Foreign Body Medical Cases
- COVID-19 and healthcare impacts
- Mesenchymal stem cell research
- Platelet Disorders and Treatments
- Peripheral Nerve Disorders
- Radiation Dose and Imaging
- Mosquito-borne diseases and control
- Advanced X-ray and CT Imaging
University of Malaya
2023
University Malaya Medical Centre
2020-2023
Joint Base San Antonio
2022
Brooke Army Medical Center
2022
Trillium Health Centre
2021
Cornell University
2004-2020
Presbyterian Hospital
2020
New York Hospital Queens
2020
NewYork–Presbyterian Hospital
2020
Texas Tech University Health Sciences Center
2016
Abstract Objective To study the contribution of interferon‐α (IFNα) and IFNγ to IFN gene expression signature that has been observed in microarray screens peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE). Methods Quantitative real‐time polymerase chain reaction analysis healthy control PBMCs was used determine relative induction a panel IFN‐inducible genes (IFIGs) by IFNα IFNγ. 77 SLE were compared those 22 disease controls 28 donors for IFIGs....
Abstract Objective Peripheral blood mononuclear cells (PBMCs) from patients with systemic lupus erythematosus (SLE) have increased expression of genes typically induced by type I interferon (IFN). However, it has been difficult to identify and quantify the factors responsible for activation IFN pathway in SLE. To characterize these mediators, we developed an assay that measures functional effects plasma or serum components on gene cultured target cells. Methods WISH epithelial cell line were...
Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation therapies but frequently remain dependent on oncogenic transcription driven by the androgen receptor (AR) and its splice variants. To discover modulators of AR-variant activity, we used a lysate-based small-molecule microarray assay identified KI-ARv-03 as an complex binder that reduces AR-driven proliferation in cancer cells. We deduced be potent, selective inhibitor CDK9, important cofactor for AR, MYC,...
Background: Loss of volume after autologous fat transfer to the breast is well documented, and various methods improve long-term survival grafts have been investigated (including both distant neighboring harvest sites), but no optimal technique has identified.
Anatomical variations can be seen in any part of the body and unless they are identified through imaging, during surgery, or on autopsy most them will never detected. sciatic nerve relation to piriformis have been described for many years so has possible implications these might play certain pathologies, such as sciatica. Identifying frequency anatomical population is relevant identify patients that not treated effectively with standard medical care. These require specialized care due their...
Transfusion of red blood cells (RBC) is a common procedure, which when prescribed inappropriately can result in adverse patient outcomes. This study sought to determine the impact multi-faceted intervention on unnecessary RBC transfusions at hospitals with baseline appropriateness below 90%.A prospective medical chart audit was conducted across 15 hospitals. For each site, 10 RBCs per month transfused inpatients were audited for 5-month pre- and 10-month post-intervention period, transfusion...
CT dose optimization is typically guided by pixel noise or contrast-to-noise ratio that does not delineate low contrast details adequately. We utilized the statistically defined detectability to study its relationship and lesion size in abdominal CT. A realistically shaped medium sized abdomen phantom was customized contain a cylindrical void of 4 cm diameter. The filled with (1% 2%) insert containing six groups targets ranging from 1.2 mm 7 size. Helical scans were performed using Siemens...
Chikungunya virus (CHIKV) is a re-emerging mosquito-borne virus, which causes epidemics of fever, joint pain and rash. There are three genotypes: West African, East/Central/South/Africa (ECSA) Asian, with the latter two predominant globally. Genotype-specific differences in clinical presentations, virulence immunopathology have been described. Macrophages key cells immune responses against CHIKV. Circulating blood monocytes enter tissue to differentiate into monocyte-derived macrophages...
Healthcare workers run the risk of contracting COVID ‐19 during course their work if required precautions and usage appropriate personal protective equipment is not adhered to. In transfusion testing laboratory, indirect exposure to may result from environmental contamination that occur through surface contact or be airborne. Handling potentially contaminated surfaces, such as sample tubes packaging, subsequent self‐inoculation mucous membranes mouth, nose eyes occur. Information on...
The authors declare no conflicts of interest relevant to this work.
Indication for
The diagnosis of platelet refractoriness is made when at least on two sequential occasions, a 10‐min to 1‐h post‐transfusion, the CCI less than 5 × 109/l, using ABO ‐identical fresh platelets 72 h old. In practice, an increase in patient's counts <10 109/l after transfusion can be used. Refractoriness due non‐immune and immune causes. Non‐immune causes include sepsis disseminated intravascular coagulation. Twenty percent cases have combination both Immune alloimmunization human leukocyte...
Dass in der Medizingeschichte noch zahlreiche interessante Heilmittel auf ihre moderne Erforschung warten, ist Fachwelt nicht erst seit dem Nobelpreis im vergangenen Jahr bekannt [1]. So wurde bereits vor mehr als einem Jahrzehnt Rezept aus ‚Lorscher Arzneibuch‘, entstanden zwischen 790 und 795, zumindest theoretisch eine antibiotische Wirkung attestiert [2]. Es könnte sich also lohnen, mittelalterlichen Handschriften nach Anregungen für neue Mittel zu suchen. Dies legt ein Forschungsprojekt...
Abstract Castration resistant prostate cancers (CRPCs) lose sensitivity to hormone therapy, but remain dependent on oncogenic transcription programs driven by the androgen receptor (AR) and other factors such as MYC. Using small molecule microarrays (SMMs), we screened HEK293 cellular lysates for compounds binding exogenously expressed ARv7, a mutant splice form of AR that drives castration resistance. Although like ARv7 MYC are considered classically undruggable, SMMs able identify...
Abstract Objectives To evaluate the performance and utility of a time–temperature indicator (TTI) to determine cumulative exposure time (CET) red cell components (RCC) temperatures above 10°C occurring within outside transfusion laboratory. Background Blood centres often use ‘30 or 60‐min rule’ for accepting RCC exposed room temperature (RT) back into inventory. Effective monitoring these deviations is however lacking. Materials Methods A Timestrip PLUS® TP153 (TS + 10) TTI was attached...