A5089777203- Computational Drug Discovery Methods
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Microbial Natural Products and Biosynthesis
- Vitamin C and Antioxidants Research
- Metabolomics and Mass Spectrometry Studies
- Diverse Scientific Research Studies
- Natural Compound Pharmacology Studies
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
University of the Western Cape
2023-2024
South African Medical Research Council
2024
National Institute for Theoretical Physics
2024
Bowen University
2019
University of Lagos
2016
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for COVID-19, which was declared a global pandemic in March 2020 by the World Health Organization (WHO). Since SARS-CoV-2 main protease plays an essential role virus's life cycle, design of small drug molecules with lower molecular weight has been promising development targeting its inhibition. Herein, we evaluated novel peptidomimetic azatripeptide and azatetrapeptide nitriles against protease. We employed...
Abstract The global rise in diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. α-Glucosidase inhibitors play crucial role managing postprandial hyperglycemia and reducing the risk of complications Type 2 DM. Quantitative Structure-Activity Relationship (QSAR) modeling is critical computational drug discovery. However, many QSAR studies on α-glucosidase often rely limited compound series statistical methods, restricting their...
Cyanocobalamin is a form of vitamin B₁₂, which water-soluble that naturally present in some foods and available as dietary supplement well prescription medication to manage illnesses. This study aimed examine the ability cyanocobalamin scavenge free radicals using vitro methods comparison ascorbic acid (control). Biochemical tests such 1'1 diphenyl-2 picryl hydrazine (DPPH) radical, Ferric Reducing Antioxidant Power (FRAP), Fe2+ chelation, hydroxyl radical (OH•), nitric oxide (NO•),...
This study investigates the phytochemical constituents in ethanol and hexane seed extract of Calophyllum inophyllum. The extracts contains saponins, tannins, glycosides, flavonoids, steroids absence alkaloids anthraquinones. FTIR shows various absorptions two Callophylum A strong absorption at 3265.3 cm -1 corresponds to O-H stretch which was observed only. C=O 1742.5 1701.5 both extracts. Other were 2853.3 , 2929.7 2922.2cm 2976.3 1578.5 1459.3 1347.4 1235.6 1312.0 1407.1cm 1449.9cm...