A5090759732- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Tryptophan and brain disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Neonatal and fetal brain pathology
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Biochemical effects in animals
- Immune cells in cancer
- Tea Polyphenols and Effects
- Nuclear Receptors and Signaling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Medicinal Plants and Neuroprotection
- Healthcare Regulation
- Blood Coagulation and Thrombosis Mechanisms
- Spinal Cord Injury Research
- Physical Education and Gymnastics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Barrier Structure and Function Studies
- Health and Well-being Studies
- Nitric Oxide and Endothelin Effects
- Adipose Tissue and Metabolism
Imperial College London
2020-2023
Hammersmith Hospital
2020-2022
Trinity College Dublin
2020
Trinity College
2019
Universidade Federal de Santa Maria
2011-2013
Astrocytes provide a vital support to neurons in normal and pathological conditions. In Alzheimer's disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. However, their role potential mechanisms whereby they affect neuroinflammation, pathology, synaptic density AD remain unclear.To explore the of on Aβ pathology neuroinflammatory markers, we pharmacologically ablated them organotypic brain culture slices (OBCSs) from 5XFAD mouse...
Alzheimer's disease, characterized by brain deposits of amyloid-β plaques and neurofibrillary tangles, is also linked to neurovascular dysfunction blood-brain barrier breakdown, affecting the passage substances into out brain. We hypothesized that treatment alterations could be beneficial in disease. Annexin A1 (ANXA1) a mediator glucocorticoid anti-inflammatory action can suppress microglial activation reduce leakage. have reported recently with recombinant human ANXA1 (hrANXA1) reduced...
Although caffeine supplementation has a beneficial effect on people with neurological disorders, its implications for oxidative damage related to seizures are not well documented. Thus the aim of this study was investigate effects two weeks (6mg/kg; p.o.) and neurochemical alterations induced by pentylenetetrazol (PTZ 60mg/kg i.p.). Statistical analyses showed that long-term rather than single dose administration decreased duration PTZ-induced in adult male Wistar rats as recorded cortical...
Traumatic brain injury (TBI) is a major cause of acquired epilepsy, and significant resources are required to develop better understanding the pathologic mechanism as targets for potential therapies. Thus, we decided investigate whether physical exercise after fluid percussion (FPI) protects from oxidative neurochemical alterations well behavioral electroencephalographic (EEG) seizures induced by subeffective convulsive doses pentylenetetrazol (PTZ; 35 mg/kg). Behavioral EEG recordings...
Background and AimsGlutaric aciduria type I (GA-I) is characterized by accumulation of glutaric acid (GA) neurological symptoms, such as cognitive impairment. Although this disease related to oxidative stress inflammation, it not known whether these processes facilitate the memory Our objective was investigate performance rat pups chronically injected with GA lipopolysaccharide (LPS) in spatial test, antioxidant defenses, cytokines levels, Na+, K+-ATPase activity, hippocampal volume. We also...
To investigate the brain-derived neurotrophic factor (BDNF) and cognitive response to a short bout of high-intensity aerobic exercise in older adults with mild impairment (MCI). Participants were randomised one two testing schedules, completing either standardised test (group A) or resting control condition B). Blood sampling measures (visuospatial learning memory, sustained attention executive function) collected at baseline (T1) postintervention (T2). An additional measurement study...
Recent evidence suggests that I2-imidazoline ligands have neuroprotective properties in animal models of neurodegeneration, such as Alzheimer’s disease (AD). We recently demonstrated the I2-ligand BU224 reversed memory impairments AD transgenic mice and this effect was not because reductions amyloid-β (Aβ) deposition. In study, our aim to determine therapeutic potential powerful analgesic ligand CR4056 5xFAD model AD, since has been proven be safely tolerated humans. Sub-chronic oral...
Background and Purpose Activation of type 2 imidazoline receptors has been shown to exhibit neuroprotective properties including anti‐apoptotic anti‐inflammatory effects, suggesting a potential therapeutic value in Alzheimer's disease (AD). Here, we explored the effects imidazoline‐2 ligand BU224 model amyloidosis. Experimental Approach Six‐month‐old female transgenic 5XFAD wild‐type (WT) mice were treated intraperitoneally with 5‐mg·kg −1 or vehicle twice day for 10 days. Behavioural tests...
Abstract Experimental and epidemiological evidence suggest that modifiable lifestyle factors, including physical exercise, can build structural cognitive reserve in the brain, increasing resilience to injury insult. Accordingly, exercise reduce increased expression of proinflammatory cytokines brain associated with ageing or experimentally induced neuroinflammation. However, cellular mechanisms by which exerts this effect are unknown, effects on classic alternative activation astrocytes...
Abstract Background Alzheimer’s disease (AD) is the most prevalent form of dementia in elderly. AD has no cure but symptomatic treatment, thus, an effective therapy urgently needed. Previously our laboratory we have explored potential neuroprotective effects coactivator for peroxisome proliferator‐activated receptor‐γ (PPARγ), ‐PGC‐1α mainly involved regulation metabolic processes and mitochondrial biogenesis. PGC‐1α been shown to be different neurodegenerative diseases its expression...
Abstract Background Astrocytes provide vital support to neurons in normal and pathological conditions. In Alzheimer's disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. However, their role potential mechanisms through which they affect neuroinflammation, pathology synaptic density AD remain unclear. Method To explore the of on neuroinflammatory markers, we pharmacologically ablated organotypic brain culture slices (OBCSs)...
Abstract Background Major depressive disorder (MDD) is linked with a 2‐fold higher risk of developing Alzheimer’s disease (AD), yet the mechanisms behind this association are unclear and confounded by psychotropic drug use. We, therefore, aimed to investigate AD‐related transcriptional changes in post‐mortem MDD brains without symptoms dementia their matched controls, taking into consideration medication‐use history. Method NanoString Technologies nCounter® analysis using Disease Panel (770...
Abstract Background : Astrocytes provide vital support to neurons in normal and pathological conditions. In Alzheimer’s disease (AD) brains, reactive astrocytes have been found surrounding amyloid plaques, forming an astrocytic scar. However, their role potential mechanisms whereby they affect neuroinflammation, pathology synaptic density AD remain unclear. Methods: To explore the of on Aβ neuroinflammatory markers, we pharmacologically ablated them organotypic brain culture slices (OBCSs)...