A5102730451- Inflammasome and immune disorders
- Cancer, Hypoxia, and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Malaria Research and Control
- Respiratory Support and Mechanisms
- Lipoproteins and Cardiovascular Health
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Vitamin C and Antioxidants Research
- Autophagy in Disease and Therapy
- interferon and immune responses
- Eicosanoids and Hypertension Pharmacology
- Intensive Care Unit Cognitive Disorders
- Cell death mechanisms and regulation
First Affiliated Hospital of University of South China
2014-2020
University of South China
2014-2020
Guangdong General Hospital
2018
Guangdong Academy of Medical Sciences
2018
Cognitive impairment is one of common complications acute respiratory distress syndrome (ARDS). Increasing evidence suggests that interleukin-1 beta (IL-1β) plays a role in inducing neuronal apoptosis cognitive dysfunction. The lung protective ventilatory strategies, which serve to reduce pulmonary morbidity for ARDS patients, almost always lead hypercapnia. Some studies have reported hypercapnia contributes the risk and IL-1β secretion outside central nervous system (CNS). However,...
Many studies have showed that apoptosis of endothelial cells plays a curial role in the progress sepsis. But simvastatin induced by sepsis is not clear. The present study aimed to investigate and its mechanism.Human umbilical vein (HUVECs) were randomly divided into three groups: control group, serum intervention group (sepsis group) simvastatin+sepsis (simvastatin group). After 24-hour incubation with corresponding culture medium, relative growth rate HUVECS different groups was detected...
Objective: The aim of this study was to verify the protective effect hypertonic saline (HS) on brain endothelial cells under hypoxic conditions and relevant underlying mechanism. Methods: bEnd.3 were treated with oxygen-glucose deprivation (OGD)-induced injury. To measure HS performance, cell viability determined using 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium salt assay, apoptosis assessed by flow cytometry Terminal deoxynucleotidyl transferase...