Abstract The aim of this study is to introduce a dental capping agent for the treatment pulp inflammation (pulpitis). Nanohydroxyapatite with Elaeagnus angustifolia L. extract (nHAEA) loaded metronidazole (nHAEA@MTZ) was synthesized and evaluated using lipopolysaccharide (LPS) in vitro model pulpitis. nHAEA through sol–gel method analyzed Scanning Electron Microscopy, Transmission Brunauer Emmett Teller. Inflammation human stem cells (HDPSCs) induced by LPS. A scratch test assessed cell...

Abstract Background The composition of breast milk (BM) is dynamic and can be influenced by maternal variables that include the diet nutritional status. This study examined association between adherence to a Mediterranean (MedDiet) total antioxidant content BM infant urine. Methods We collected 350 samples from mothers urine their infants. dietary intakes were recorded using validated 65 items-food frequency questionnaire (FFQ). status was assessed ferric reducing/antioxidant power (FRAP),...

<title>Abstract</title> Free-living amoebae (FLAs) are widely prevalent protozoa found in various natural and man-made environments. In Iran, there have been few studies examining the contamination of hospital environments with FLAs <italic>Legionella</italic> spp., none explored coexistence these two organisms. Thus, this study aims to investigate spp. water resources hospitals Birjand city. Water samples were collected from sources different departments city, transferred laboratory. One...

Human dental pulp stem cells (hDPSCs) have significant potential of immunomodulatory for therapeutic and regenerative biomedical applications compared to other mesenchymal (MSCs). Nowadays, alteration gene expression is an important way improve the performance MSCs in clinic. MicroRNAs (miRs) CD200 are known modulate immune system MSCs. Curcumin famous its anti‐inflammatory impacts. Phytosomal curcumin (PC) a nanoparticle synthesized from that removes drawbacks curcumin. The purpose this...

Abstract Background Human milk composition varies over time within an individual mother as well between lactating mothers due to several factors including maternal health, diet, and nutritional status. Therefore, improving nutrition status during gestation breastfeeding is crucial for the health of both infants. Diet can enhance oxidant-antioxidant balance human milk. This study aimed investigate association with dietary patterns identified by using principal component analysis. Method...

Allergic rhinitis (AR) is one of the health problems in world. It necessary to develop new treatment procedure for control this disease. The aim study was assess effect Zofa (Nepeta bracteata Benth) on AR patients.In double-blind randomized clinical trial study, 71 patients (37 and 34 placebo group) participated. In group, N. syrup (NBS) used 4 weeks as three times a day. efficacy drug regarding symptoms (rhinorrhea, sneezing, nasal obstruction, itchy nose, ocular symptoms) were evaluated...

Abstract Colorectal cancer (CRC) is a global public health problem. Despite the major milestone in early diagnosis and treatment of colorectal cancer, prevalence CRC rates still rising. The etiology unknown but we know influenced by both environment genetic factors. In this study, aimed to elucidate role vitamin D receptor gene polymorphic regions; FokI TaqI single nucleotide polymorphisms, increasing risk Birjand population. One hundred patients with 100 healthy controls recruited study....

Gastric cancer is the second cause of cancer-related mortality and fourth most common cancers worldwide. Owing to immune modulatory effect vitamin D in body, role receptor gene regulation receives a great deal research interest. The aim current study was highlight association between two variants TaqI FokI gastric predisposition sample South Khorasan population. present investigation consisted 69 patients affected with 100 healthy individuals. genomic DNA extracted by salting out protocol...

Background: Multiple sclerosis along with its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory and degenerative diseases of the central nervous system (CNS). Due to unknown cause disease, most common treatments MS targeted for reduction inflammation repairment CNS tissue damage, especially myelin restoration. immune protective nature herbs, it may be useful evaluate impact herbs in diet regimen patients their immune-mediated effects. The purpose this...

Abstract Purpose The green synthesis of nanoparticles has recently opened up a new route in material production. aim this study was to evaluate the effect nanohydroxyapatite (nHA) synthesized from Elaeagnus angustifolia (EA) extract polycaprolactone (PCL) nanofibers (PCL/nHAEA) odontogenic differentiation dental pulp stem cells (DPSCs) and their potential applications for dentin tissue engineering. Methods Green nHA via EA (nHAEA) done by sol–gel technique. Then electrospun nanocomposites...

The purpose of this study was to investigate the effects human milk exosomes (HM-Exos) on viability, migration, and inflammatory responses lipopolysaccharide (LPS)-exposed dental pulp stem cells (HDPSCs) in vitro.HM-Exos were isolated, dynamic light scattering (DLS), scanning electron microscopy (SEM), transmission (TEM) used analyze their physical properties (size shape). To construct an vitro inflammation model, HDPSCs exposed LPS. MTT test migration assay effect HM-Exos cell proliferation...

Low high density lipoprotein cholesterol (HDL-C) is a known risk factor of coronary artery disease. Apolipoprotein A1 (APOA1) the most abundant component HDL-C. This study aimed at identifying sequence variations (rare and common) in APOA1 gene its association with serum HDL-C levels. was conducted from April 2012 to February 2013 on 79 Tehranians (participants Tehran Lipid Glucose Study) extremely low (within 5th percentile) 63 individuals 95th After DNA amplification by PCR, sequencing all...

Dental pulp stem cells (DPSCs) have been recommended as promising candidate for cell-based therapeutic applications due to high potentials in tissue repair/regeneration and modulation of immune responses. The gene expression change strategy by natural plant enhancers is an available opportunity improve the stemness properties these cells. objective this research was evaluation Crocin effects (saffron plant's bioactive compound) on immunoregulation regeneration-related biomarkers human DPSCs....

Apolipoprotein A2 (APOA2) is the second major apolipoprotein of high-density lipoprotein cholesterol (HDL-C). The study aim was to identify APOA2 gene variation in individuals within two extreme tails HDL-C levels and its relationship with level.This cross-sectional survey conducted on participants from Tehran Glucose Lipid Study (TLGS) at Research Institute for Endocrine Sciences, Tehran, Iran April 2012 February 2013. In total, 79 low (≤5th percentile age gender) 63 high (≥95th were...

Polycystic ovarian syndrome (PCOS) is the most common cause of infertility and endocrine disorders in women childbearing age. In Persian medicine,

Abstract Background Cerebellar ataxia, mental retardation, and dysequilibrium (CAMRQ) syndrome is a rare early‐onset neurodevelopmental disorder. Four subtypes of this have been identified, which are clinically genetically different. To date, altogether 32 patients described with ATP8A2 mutations phenotypic features assigned to CAMRQ type 4. Herein, three additional in an Iranian consanguineous family non‐progressive cerebellar severe hypotonia, intellectual disability, dysarthria, atrophy...