A5071924577- Organophosphorus compounds synthesis
- Fluorine in Organic Chemistry
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Phosphorus compounds and reactions
- Synthesis and Reactions of Organic Compounds
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Carbohydrate Chemistry and Synthesis
- Synthesis and Catalytic Reactions
- Chemical Synthesis and Analysis
- Boron Compounds in Chemistry
- Cyclopropane Reaction Mechanisms
- Synthesis and Biological Evaluation
- Pneumocystis jirovecii pneumonia detection and treatment
- Sulfur-Based Synthesis Techniques
- Synthetic Organic Chemistry Methods
- Asymmetric Hydrogenation and Catalysis
- Radiopharmaceutical Chemistry and Applications
- Advanced Synthetic Organic Chemistry
- Vanadium and Halogenation Chemistry
- Boron and Carbon Nanomaterials Research
- Bone health and treatments
- Synthesis and Reactivity of Heterocycles
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
National Academy of Sciences of Ukraine
2016-2025
Institute of Organic Chemistry
2016-2025
National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”
2014-2022
Enamine (Ukraine)
2020
Oak Ridge National Laboratory
2011
A convenient protocol for the two-step organocatalytic decarboxylative borylation of 1,1-disubstituted, 1,2-disubstituted, and bicyclic cyclopropane carboxylic acids via corresponding N-hydroxyphthalimide esters is described, using tert-butyl or ethyl isonicotinate as an inexpensive readily available catalyst. The scope method was demonstrated, being limited mainly by electron-poor substrates. reaction sequence showed good scalability (up to 51.5 g) excellent trans diastereoselectivity (for...
A new synthetic procedure for preparing tetrabutylammonium closo-dodecaborate (Bu4N)2B12H12 by the solvent-free pyrolysis of tetrahydroborate Bu4NBH4 has been developed. The also provides isolation pure octahydrotriborate Bu4NB3H8 as a by-product. main advantages route proposed are convenience and utilization readily available starting materials. compounds prepared have characterized NMR IR spectroscopy. Based on DFT calculations normal modes [B3H8]- [B12H12]2- anions, assignment absorption...
Preparation of 2,2‐disubstituted and 2‐monosubstituted alkenylboronic acid esters from aliphatic aromatic ketones aldehydes by the boron‐Wittig olefination with bis[(pinacolato)boryl]methane was examined applied on multigram scale. The influence substrate steric electronic features overall efficiency stereochemical outcome reaction studied. Additionally, a series diversely functionalized (hetera)cycloalkylidenemethyl (hetera)cycloalkyl boronic acid‐derived building blocks synthesized.
A convenient synthesis of methyl α-iminotrifluoropropionate (methyl 3,3,3-trifluoro-2-iminopropanoate, 3), based on the aza-Wittig reaction trifluoropyruvate with triphenylphosphine imide, was developed. The synthetic potential N-H imine 3, existing as equilibrium mixture (10:1) E/Z isomers, in preparation functionalized acyclic and heterocyclic derivatives possessing a pharmacophoric trifluoroalanine fragment, is disclosed.
The chemoselectivity of reactions between α-haloimines - compounds containing a Hal-C-C=N-skeleton and nucleophilic phosphorus derivatives are discussed systematically. synthetic potentialities, as well possible mechanistic pathways this currently developing field organophosphorus chemistry considered. Phosphorylation the leads mainly to C- or N-phosphorylated final products, selectivity being dependent on type halogen, substituents at imine carbon nitrogen atoms, nature reagent. main...
An approach to the synthesis of oxa‐ and azabicyclo[ n .1.0]alkan‐1‐yl trifluoroborates on a multigram scale was developed. Two synthetic strategies were evaluated: first based lithiation–borylation corresponding 2‐bromoallyl derivatives, other relying regioselective hydroboration appropriate hetera‐substituted enynes. The second method appeared be more efficient in terms scalability substrate scope. Further steps included ring closing‐metathesis, mild palladium‐catalyzed cyclopropanation...
In the present review we attempt to systematize and generalize available data on prototropy in imidoylphosphonates containing α-hydrogen atoms N- or C-alkyl groups of C=N bond. Prototropic transitions C=N-CH triad leading biorelevant α-aminophosphonates are main focus review. Central this endeavour is elucidation effect that phosphoryl phosphonium moiety exerts phosphorylated 2-azaallylic triad. Keywords: imidoylphosphonates, imidoyl chlorides, aminophosphonates, proton transfer,...
Abstract We have developed a convenient synthetic approach to highly reactive N ‐(arylsulfonyl)trichloro‐ and ‐trifluoroacetimidoyl chlorides 2 by reacting the corresponding ‐acylsulfonamides with PCl 5 . The interaction of imidoyl phosphites proceeds through different pathways depending on substituents in reagents, leads ‐arylsulfonyl‐ ‐trichlorovinylphosphoramidates 4 , 1‐arylsulfonylamino‐1‐chlorotrifluoroethylphosphonate C ‐bis(phosphorylated) ‐dihalovinylsulfonamides 8...
A convenient synthetic approach to previously unknown N-H imidoyl phosphonates, based on addition of dialkyl phosphites trifluoroacetonitrile, has been developed. The potential such imines, which exist as equilibrium mixtures E/Z-isomers, was demonstrated by their easy reduction and functionalization with O- P-centered nucleophiles, afford derivatives α-aminophosphonic acids containing a trifluoromethyl group. Furthermore, interaction mercaptoacetic acid proceeds intramolecular cyclization...
Abstract The Ti(OPr‐i) 4 ‐mediated three–component condensation of enantiomeric Ellman's amides, dimethylphosphine oxide, and aliphatic, aromatic or heteroaromatic aldehydes proceeds in high yields diastereoselectivities enabling the rapid, scalable general asymmetric synthesis (α‐amino)dimethylphosphine oxide derived compounds bearing alkyl, cycloalkyl hetaryl group at chiral carbon atom. Asymmetric α‐amino‐α‐polyfluoroalkyl oxides was accomplished through diastereoselective addition to...
Several methods for preparation of closo-decaborate (B10H102- as polyalkylammonium salts) – a key compound synthesis carborane by pyrolysis tetraethylammonium borohydride were examined. The studied reactions included variation decomposition temperature, liquid medium, pressure and reaction time. products analyzed 11B 1H NMR spectroscopy, and, in some cases, IR-spectroscopy. It was found that Et4NBH4 solid state well suspension silicone fluid led to the mixtures (Et4N)2B10H10 (Et4N)2B12H12....
Abstract A highly diastereoselective addition of nitromethane to the C=N bond enantiomeric fluorine containing Ellman's aldimines, R F CH=NS(O) tert ‐Bu (R =CF 3 , CF 2 Br, C 5 HC 4 ), has been successfully developed. The synthetic potential resulting β‐nitrosulfinylamides was demonstrated through their conversion into optically active α‐fluoroalkylated 1,3‐nitroamines, 1,3‐diamines, and 4‐fluoroalkylated imidazolidin‐2‐ones.
Abstract A convenient preparative approach to previously unknown, highly electrophilic C ‐phosphorylated N ‐arylsulfonylimines 1 , based on fairly readily accessible α‐phosphorylated sulfonamides 5 has been developed. Compounds react with trialkyl phosphites or ethyl diphenylphosphinite in the aza‐Perkow reaction scheme give ‐diphosphorylated ‐dichlorovinylsulfonamides 8 . On treatment O‐ and S‐nucleophilic agents (alcohols, thiols, thiophenols), forms addition products 12 15 functionalized...