A5027148319- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- DNA and Nucleic Acid Chemistry
- Trace Elements in Health
- Plant Micronutrient Interactions and Effects
- RNA and protein synthesis mechanisms
- Magnetism in coordination complexes
- Iron Metabolism and Disorders
- Advanced biosensing and bioanalysis techniques
- Molecular Sensors and Ion Detection
- Metal-Organic Frameworks: Synthesis and Applications
- Supramolecular Chemistry and Complexes
- Organometallic Complex Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- HIV/AIDS drug development and treatment
- Heavy metals in environment
- Crystal structures of chemical compounds
- Chromium effects and bioremediation
- Machine Learning in Materials Science
- Click Chemistry and Applications
- Carbohydrate Chemistry and Synthesis
- RNA modifications and cancer
- Mesenchymal stem cell research
University of Zurich
2014-2025
TU Dortmund University
1999-2021
Stony Brook University
2001-2021
University of Basel
2019-2021
University of Konstanz
2021
MSD (Mexico)
2021
Columbia University
2021
Walter de Gruyter (Germany)
2021
University Hospital Münster
2016
University of Birmingham
2013
This review summarizes the recent development of G4 DNA targeted metal complexes and discusses their potential as anticancer drugs.
Type 2 diabetes is associated with numerous long-term complications. This study aims to investigate whether impaired function of tissue-resident multipotent cells play role in pathogenesis allied Adipose-tissue-derived mesenchymal stem (ASCs) derived from nondiabetic (nASCs) and diabetic (dASCs) donors were compared regard glucose metabolism, cell replication, apoptosis, differentiation potential. The data evidenced that elevation reduces proliferative capacity both dASCs nASCs, but impacts...
Coordination of (en)PdII entities (en = ethylenediamine) forces the two pyrazine halves 2,2′-bipyrazine ligands (bpz) molecular triangle [{(en)Pt(bpz))}3]6+ to adopt a cisoid arrangement. The resulting cationic (+12) complex [{(en)Pt(bpz)Pd(en)}3]12+ (see picture) displays pronounced affinity for anions and encapsulates simultaneously NO3− PF6− ions, which has been confirmed by X-ray structural analysis.
The molecular triangle [{enPt(bpz-N4,N4')}3]6+ (en = ethylenediamine; bpz 2,2'-bipyrazine) has been crystallized as a C2-symmetric species (1), compound of approximate C3 symmetry, and mixture both forms (1b). two triangles differ in their topologies, Pt−Pt distances, anion binding properties. While for the C2 form insertion single PF6- central cavity is seen 1b, 1a 1b incorporate either different anions simultaneously, NO3- ClO4- (1a), or only Anion inclusion also occurs solution detected...
Getting to the heart of it: Co-crystallization an RNA three-way junction with a cylindrical di-iron(II)-based anti-cancer drug (green) results in π-stacking interactions between cylinder and central base pairs structure. The shape, size, cationic nature were found be responsible for this perfect fit. Native gel electrophoresis studies confirmed stabilization by iron(II) cylinder. As service our authors readers, journal provides supporting information supplied authors. Such materials are peer...
Depending on the configuration of metal unit (cis or trans) and sequence coordination by six-membered heterocycles uracil, 1-methylcytosine, 2-amino-pyridine, complexes different topologies—open box, rectangle, hexagon—are obtained (see below). These contain six eight units (with PtII, NiII, PdII, CuII, AgI; represented spheres) in unusual relative arrangements.
Abstract Steric blockage of the N1 and N7 sites 9‐methyladenine for metal complexation is achieved by twofold methylation exocyclic amino group. With 6′,6′,9‐trimethyladenine (TrimeA), binding MII(dien) (M = Pt, Pd) as well trans ‐[Pt(NH 3 ) 2 Cl] + therefore takes place through N 3. X‐ray crystal structure determinations NMR spectroscopic studies three compounds are reported, effects Pt II Pd on geometry acid‐base properties TrimeA ligand have been measured compared with those free base....
The X-ray crystal structures of two complexes the composition trans-[Pt(NH3)2(9-EtG-N7)(1-MeC-N3‘)]X·nH2O (1) with 9-EtG = 9-ethylguaninate and 1-MeC 1-methylcytosine are reported. 1b (X picrate, n 1) crystallizes to produce a dimetalated base quartet, held together by H-bonding interactions between pairs cations. This feature essentially corresponds solution structure previously proposed us on basis 1H NMR ESI-MS, interaction aromatic H5‘ proton deprotonated N1 position 9-EtG. 1c...
Reactions between the mononuclear mixed-nucleobase complex [Pt(en)(UH-N1)(CH2-N3)]+ (1; en: ethylenediamine; UH-N1: uracil monoanion bonded through N1 atom; CH2-N3: neutral cytosine N3 atom) and [Pd(II)(en)] or [Pd(II)(2,2'-bpy)] (2,2'-bpy: 2,2'-bipyridine) lead to libraries of compounds different stoichiometries connectivities. In these compounds, palladium entity binds cross-links either sites and/or cytosine, following deprotonation positions give dianions (U) monoanions (CH). Cyclic...
A series of pyrazine (pz) complexes containing cis-(NH3)2PtII, (tmeda)PtII (tmeda = N,N,N',N'-tetramethylethylenediamine), and trans-(NH3)2PtII entities have been prepared characterized by X-ray crystallography and/or 1H NMR spectroscopy. In these compounds, the pz ligands act as monodentate (1−3) or bidentate bridging (4−7). Three variants latter case are described: a dinuclear complex [PtII]2 (4b), cyclic tetranuclear [PtII]4 (5), trinuclear mixed-metal [Pt2Ag] (7). Mono- binding modes...
Labeling of long RNA molecules in a site-specific yet generally applicable manner is integral to many spectroscopic applications. Here we present novel covalent labeling approach that and scalable intricately folded RNAs. In this approach, custom-designed DNA strand hybridizes the guides reactive group target preselected adenine residue. The functionalized nucleotide along with concomitantly oxidized 3'-terminus can subsequently be conjugated two different fluorophores via bio-orthogonal...
Zinc (Zn) is an essential micronutrient, while cadmium (Cd) a highly toxic pollutant. Due to their chemical similarity, both metals are absorbed by plants through the same pathways, including membrane proteins and vascular tissues. Plants mitigate Cd toxicity chelating with thiol-rich organic ligands proteins, such as metallothioneins (MTs). Recent studies have shown that Zn isotopes inversely fractionated in cereals like wheat rice, grains accumulating light heavy isotopes. As Cd-thiol...
The open "molecular box" [(en)Pt(UH-N(1),N(3))](4)(NO(3))(4) (with en = 1,2-diaminoethane, UH uracil monoanion) resembles calix[4]arenes in its structure and solution dynamics. It adopts a 1,3-alternate conformation the solid-state (1a), but after deprotonation to [(en)Pt(U-N(1),N(3))](4), second major species (cone conformer (1b-4H(+))) occurs. 1b-4H(+) acts as an efficient ligand for additional metal ions through oxo-surface formed by four O(2) exocyclic atoms of nucleobases. As shown...