A5103275175- Cell Adhesion Molecules Research
- Organoselenium and organotellurium chemistry
- Advertising and Communication Studies
- Research on Leishmaniasis Studies
- Synthesis and biological activity
- Selenium in Biological Systems
- Aging, Health, and Disability
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis of heterocyclic compounds
- Chemistry and Chemical Engineering
- Renal Transplantation Outcomes and Treatments
- Metabolism and Genetic Disorders
- Antioxidant Activity and Oxidative Stress
- Science and Education Research
- Neurobiology and Insect Physiology Research
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Child Nutrition and Feeding Issues
- Communication and COVID-19 Impact
- Dialysis and Renal Disease Management
- Nuts composition and effects
- Regional Development and Innovation
- Supramolecular Chemistry and Complexes
- IL-33, ST2, and ILC Pathways
- Minimally Invasive Surgical Techniques
Universidade Federal de Campina Grande
2009-2025
Universidade Federal da Paraíba
2009-2022
Discovery Air (Canada)
2020
Aix-Marseille Université
2015
Inserm
2015
Instituto de Investigación Sanitaria La Fe
2013
Hospital Universitari i Politècnic La Fe
2013
Pontificia Universidad Católica de Chile
2013
Centre National de la Recherche Scientifique
1998-1999
Institut de Chimie
1994
Motivated to expand the investigation of antimicrobial profile 2-selenocetanilides and ebselen analogue, four compounds were prepared using a cleaner method in water as solvent. Thus, 2-selenoacetanilides obtained by alkylation reaction 2-chloroacetanilides with benzoyl (or phthalylglycyl) selenoate generated situ under mild conditions. New compound 3a was submitted single crystal X-ray diffraction, where only Z-conformer observed. In silico ADMET test required predicate drug-like character...
Motivated by the search for novel antimicrobials against opportunistic resistant pathogens and based on reported antimicrobial activity of phthalimides, two series phthalimide N-phthaloylglycine esters were designed to investigate whether addition butyl aryl groups enhances their properties. Thus, in vitro activity, antifungal mechanism action, effect combined with Chloramphenicol, silico/vitro toxicity, a docking molecular studied. Phthalimide obtained yields 75–98%. ester 3b (R = Me)...
Increased reactive oxygen species (ROS) production is associated with inflamed ileal lesions in Crohn's disease colonized by pathogenic adherent–invasive Escherichia coli LF82. We investigated whether such bacteria can modulate ROS epithelial cells, thus impacting on inflammation and mucin expression. Ileal from patients were incubated cultured T84 was assayed using the luminol-amplified chemiluminescence method. The gentamicin protection assay used for bacterial invasion of cell. expression...
Abstract: According to the PLOS Neglected Tropical Diseases Journal, infection caused by Gram-negative bacterium Escherichia coli is a neglected tropical disease. Staphylococcus aureus most dangerous Grampositive among staphylococcal bacteria. Moreover, resistance Mycobacterium tuberculosis an urgent public health issue. In this sense, cinnamic acid and acetamide derivatives have been used as strategic nuclei in design of antimicrobial agents. With aim investigating whether antibacterial...
Background: This study assessed the effects of Baru (Dipteryx alata Vog.) almond oil supplementation on vascular function, platelet aggregation, and thrombus formation in aorta arteries Wistar rats. Methods: Male rats were allocated into three groups. The control group (n = 6), a receiving at 7.2 mL/kg/day (BG mL/kg, n (iii) 14.4 6). was administered for ten days. Platelet formation, reactive oxygen species production evaluated end treatment. Results: reduced aggregation (p < 0.05)...
Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant antiarrhythmic properties, are also used against diabetes. N-3 C-5 substituted imidazolidines examples such products. As such, we have developed synthesis 2,4-dione 2-thioxo-4-one imidazolidinic by reaction amino acids C-phenylglycine, phenyl isocyanate isothiocyanate. Four amino-derivatives IG(1-4) eight derivatives, IM(1-8), were obtained in yields 70-74%. The mass, infrared, (1)H (13)C-NMR...
This study describes a virtual screening performed for two series of selenides (28 compounds), derived from N-phenylacetamides chlorides and 7-chloro-quinoline, to determine their potential leishmanicidal activity against Leishmania amazonensis donovani. Seven compounds were predicted as leishmanicides; therefore, they synthesized elemental selenium, precursor the production NaHSe, subsequent reactions with 4,7-dichloro-quinoline performed. The characterized by infrared (IR), 1H 13C nuclear...
The heterodimer α6β4 is a major integrin and the main laminin receptor in epithelia. α6 subunit proteolytically cleaved, probably by furin, glycosylated during its biosynthesis. In present work, we have investigated kinetics of assembly process heterodimers colonic adenocarcinoma cell line HT29‐D4. We demonstrate that association β4 precursors occurs within ER, while endoproteolytic cleavage pro‐α6 later, trans ‐Golgi network. When was blocked ER treatment with brefeldin A, maturation...
Leishmaniasis is a neglected disease that does not have adequate treatment. It affects around 12 million people the world and classified as by World Health Organization. In this context, strategies to obtain new, more active less toxic drugs should be stimulated. Sources of natural products combined with synthetic chemoinformatic methodologies are used molecules most likely effective against specific disease. Computer-Aided Drug Design has become an indispensable tool in pharmaceutical...
As plantas medicinais são espécies vegetais que apresentam em sua composição substâncias biologicamente ativas, nas quais conferem as suas propriedades terapêuticas. Nessa perspectiva, o presente estudo apresenta como objetivo avaliar potencial antibacteriano da espécie vegetal braúna-do-sertão (Schinopsis brasiliensis). Os aspectos metodológicos desta pesquisa remetem a um de revisão integrativa literatura, com caráter descritivo e abordagem qualitativa, realizada nos meses julho dezembro...
Aim: Selenium-based compounds have antitumor potential. We used a ligand-based virtual screening analysis to identify selenoglycolicamides with potential activity. Results & Conclusion: Compounds 3, 6, 7 and 8 were selected for in vitro cytotoxicity tests against various cell lines, according spectrophotometry results. Compound 3 presented the best results promyelocytic leukemia line (HL-60) was able induce death at frequency similar that observed doxorubicin. The docking study showed...
The authors wish to make the following correction their paper [1], published recently in Molecules. coauthor RalineMendonça dos Anjos was omitted from author list, which should read as follows: [...]