A5059671389- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Cellular transport and secretion
- Neurobiology and Insect Physiology Research
- Marine Invertebrate Physiology and Ecology
- Toxin Mechanisms and Immunotoxins
- Neuroinflammation and Neurodegeneration Mechanisms
- Insect Resistance and Genetics
- Genetics, Aging, and Longevity in Model Organisms
- Immune Response and Inflammation
- Cardiac electrophysiology and arrhythmias
- Marine Toxins and Detection Methods
- Nicotinic Acetylcholine Receptors Study
- Plant Stress Responses and Tolerance
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Insect and Pesticide Research
- Cellular Mechanics and Interactions
Pennsylvania State University
2015-2020
Penn State Milton S. Hershey Medical Center
2018
The major histocompatibility complex I (MHCI) pathway, which canonically functions in innate immune viral antigen presentation and detection, is functionally pleiotropic the central nervous system (CNS). Alternative roles include developmental synapse pruning, regulation of synaptic plasticity, inhibition neuronal insulin signaling; all processes altered during brain aging. Upregulation MHCI components with aging has been reported; however, no systematic examination cellular localization,...
In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor ion channels and required plasma membrane diffusion barrier excludes somatodendritic proteins from axon. An unusually long exon to encode this 480Kd thought have been inserted only recently during evolution, so ankyrin-based AIS scaffold has viewed adaptation fast, precise signaling. We re-examined evolution...
Abstract TRPV ion channels are directly activated by sensory stimuli and participate in thermo-, mechano- chemo-sensation. They also hypothesized to respond endogenous agonists that would modulate responses. Here, we show the nicotinamide (NAM) form of vitamin B 3 is an agonist a Caenorhabditis elegans channel. Using heterologous expression Xenopus oocytes, demonstrate NAM soluble for channel consisting well-studied OSM-9 subunit relatively uncharacterized OCR-4 as well orthologous...
The Shaker-like family of voltage-gated K+ channels comprises four functionally independent gene subfamilies, Shaker (Kv1), Shab (Kv2), Shaw (Kv3), and Shal (Kv4), each which regulates distinct aspects neuronal excitability. Subfamily-specific assembly tetrameric is mediated by the N-terminal T1 domain segregates Kv1–4, allowing multiple channel types to function independently in same cell. Typical Kv subunits can form functional as homotetramers, but a group mammalian Kv2-related genes...