A5029471537- Cardiomyopathy and Myosin Studies
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Internet Traffic Analysis and Secure E-voting
- Cardiovascular Effects of Exercise
- Genetics and Neurodevelopmental Disorders
- Sports injuries and prevention
- Data Quality and Management
- Privacy-Preserving Technologies in Data
Spanish National Centre for Cardiovascular Research
2014-2023
Atos (Spain)
2022
Abstract We present PolicyCLOUD: a prototype for an extensible serverless cloud-based system that supports evidence-based elaboration and analysis of policies. PolicyCLOUD allows flexible exploitation management policy-relevant dataflows, by enabling the practitioner to register datasets specify sequence transformations and/or information extraction through registered ingest functions. Once possibly transformed dataset has been ingested, additional insights can be retrieved further applying...
Meis1 is a highly conserved transcription factor that activated in regionally restricted manner from early stages of development. belongs to the three amino acid loop extension (TALE) homeodomain family. Together with Pbx1, plays major role as Hox cofactor, and therefore, an essential development several embryonic organs systems, including limbs, heart, blood, vasculature. In addition, required for Hox-free regions interacts non-Hox non-homeodomain factors. During post-natal life involved...
Abstract The most prevalent genetic form of inherited arrhythmogenic cardiomyopathy (ACM) is caused by mutations in desmosomal plakophilin-2 ( PKP2 ). By studying pathogenic deletion the protein PKP2, here we identify a general mechanism which delocalization restricts actomyosin network organization and cardiac sarcomeric contraction this untreatable disease. Computational modeling variants reveals that carboxy-terminal (CT) domain required for N-terminal stabilization, determines cortical...