A5073491872- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Synthetic Organic Chemistry Methods
- Cyclopropane Reaction Mechanisms
- Catalytic Alkyne Reactions
- Crystallography and molecular interactions
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Solid-state spectroscopy and crystallography
- Crystal structures of chemical compounds
- Asymmetric Hydrogenation and Catalysis
- Marine Sponges and Natural Products
- Cancer Treatment and Pharmacology
- Organic and Molecular Conductors Research
- Metal-Organic Frameworks: Synthesis and Applications
- Oxidative Organic Chemistry Reactions
Centre National de la Recherche Scientifique
2017-2025
Centrale Marseille
2017-2025
Le Mans Université
2019-2021
Aix-Marseille Université
2018-2021
Institut des Molécules et Matériaux du Mans
2019-2021
We describe an operationally simple, good-yielding, two-step cascade process to convert biscyclopropanes 1 into high-value benzocyclobutene building blocks 3. This study highlights the novel reactivity of our "in-house" donor-acceptor cyclopropane, achieving complete diastereoselectivity and regioselectivity transfer.
A cobalt-catalysed C–H allylation of aromatic and heteroaromatic compounds with vinylaziridines is described.
Abstract An access to functionalised eight‐membered carbocyclic ring compounds was developed by simply stirring an unusual vinylogous Donor‐Acceptor Cyclopropane (DAC) in boiling o ‐xylene. Both experimental and computational studies were performed explain the diastereoselectivity/regioselectivity transfer observed provide overall picture of mechanism. magnified image
A convergent and rapid synthesis of original C2,C3-unsaturated, C11,C13-keto–enol macrocycles with a peloruside skeleton has been developed. These unsaturated constitute valuable platforms to access analogues high diversity. The four-fragment strategy implemented features two aldol-type couplings the central C12–C14 building block TES-diazoacetone late-stage ring-closing metathesis. Enantiopure analogue 18ab showed antiproliferative activity in low micromolar range on NCI MCF7 tumor cell lines.
Abstract Transition metal‐catalyzed hydroalkynylation reactions are efficient transformations allowing the straightforward formation of functionalized alkynes. Therein, we disclose cobalt‐catalyzed vinylaziridines giving rise to both linear and branched enynes. The optimization reaction conditions allowed determine key parameters cobalt‐based catalytic system. scope investigation showed that is mainly limited phenylacetylene derivatives. In most cases enynes were isolated in equimolar...
Chloroazaphosphatranes, the corresponding halogenophosphonium cations of Verkade superbases, were evaluated as a new motif for halogen bonding (XB). Their modulable synthesis allowed synthetizing chloroazaphosphatranes with various substituents on nitrogen atoms. The binding constants determined from NMR titration experiments Cl–, Br–, I–, AcO–, and CN– anions are comparable to those obtained conventional iodine-based monodentate XB receptors. Remarkably, protonated azaphosphatrane...
Abstract Non‐covalent interactions play an important role in all sub‐fields of chemistry, including catalysis, where different natures can work together to improve reactivitiy and selectivity. Several families molecules that incorporate both hydrogen bond (HB) halogen bonding (XB) donors have already been studied. However, there is a lack data on how grafting HB iodoazolium salts could impact their association reactivity properties. Herein, we disclose the synthesis library bearing varied...
Aldol addition of α-triisopropylsilyl-α-diazoacetone (TIPS-diazoacetone), promoted by excess lithium diisopropylamide (LDA), was developed and applied to the synthesis original C-TIPS diazoaldols, diazoketols, a related Mannich-type product. An unprecedented mechanistic pathway has been proposed, involving lithiated triazene intermediate resulting from nucleophilic LDA on diazo moiety, supported experimental results DFT calculations.