A5066097166- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Histiocytic Disorders and Treatments
- Global Cancer Incidence and Screening
- T-cell and Retrovirus Studies
- Microscopic Colitis
- Acute Lymphoblastic Leukemia research
- AI in cancer detection
- Salivary Gland Tumors Diagnosis and Treatment
- Aortic Thrombus and Embolism
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Parvovirus B19 Infection Studies
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gastrointestinal motility and disorders
- Lymphadenopathy Diagnosis and Analysis
- Helicobacter pylori-related gastroenterology studies
- Cancer Genomics and Diagnostics
- Eosinophilic Disorders and Syndromes
- Ethics in Clinical Research
Kamuzu Central Hospital
2016-2018
University of North Carolina at Chapel Hill
2016-2018
University of Malawi
2016-2018
Centre for Bhutan Studies and GNH Research
2014-2017
African Institute for Development Policy
2015
Armed Forces Medical College
2006
The incidence of lymphoproliferative disorders (LPDs) is increasing in sub-Saharan Africa (SSA) due to population growth, aging, and human immunodeficiency virus (HIV). Despite significant burden, resources for diagnosis treatment LPDs are limited, with little infrastructure deliver modern pathology services. Diagnostic therapeutic decisions therefore frequently made without tissue confirmation, leading high rates misdiagnosis inappropriate treatment.We have established a laboratory Malawi...
There are no prospective studies of aggressive non-Hodgkin lymphoma (NHL) treated with CHOP in sub-Saharan Africa. We enrolled adults NHL Malawi between June 2013 and May 2015. Chemotherapy supportive care were standardized, HIV+ patients received antiretroviral therapy (ART). Thirty-seven 58 (64%) HIV+. Median age was 47 years (IQR 39–56), 35 (60%) male. Thirty-five had stage III/IV, 43 (74%) B symptoms, 28 (48%) performance status ≥2. B-cell predominated among patients, all T-cell occurred...
Point-of-care tools are needed in sub-Saharan Africa (SSA) to improve pediatric Burkitt lymphoma (BL) diagnosis and treatment. We evaluated plasma Epstein–Barr virus (pEBV) DNA as a BL biomarker Malawi. Prospectively enrolled children with were compared classical Hodgkin (cHL) nonlymphoma diagnoses. Pediatric patients received standardized chemotherapy supportive care. pEBV was measured at baseline, mid-treatment, treatment completion. Of 121 assessed children, detected 76/88 (86%) BL, 16/17...
Abstract Background Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub‐Saharan Africa where human immunodeficiency virus (HIV) and Epstein–Barr (EBV) prevalent. Methods We describe a prospective cHL cohort in Malawi enrolled 2013 to 2015. Patients received standardized treatment evaluation, including HIV status EBV testing tumors plasma. Results Among 31 patients with confirmed cHL, the median age was 19 years (range, 2–51 years) 22 (71%) were male. Sixteen...
Burkitt lymphoma (BL) is the most common paediatric cancer in sub-Saharan Africa (SSA). Anthracyline-based treatment standard resource-rich settings, but has not been described SSA. Children ≤18 years of age with newly diagnosed BL were prospectively enrolled from June 2013 to May 2015 Malawi. Staging and supportive care standardized, as was CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) for six cycles. Among 73 children BL, median 9·2 (interquartile range 7·7-11·8), 48 (66%)...
Plasmablastic lymphoma (PBL) clinical descriptions are scarce from sub-Saharan Africa (SSA) where both HIV and EBV highly endemic. We identified 12 patients with pathologically confirmed PBL a prospective cohort in Lilongwe, Malawi. Median age was 46 (range 26–71), seven (58%) were male, six (50%) HIV-positive. Eight treated CHOP four modified EPOCH regimen. One-year overall survival 56% (95% CI 24–79%), without clear differences based on status. occurs Malawi HIV-positive HIV-negative...
Outcomes for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa (SSA) are poorly described. We report mature data from one of the first prospective SSA cohorts. Patients aged ≥18 years with DLBCL were enrolled Malawi 2013-2017. Participants treated CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy and concurrent antiretroviral therapy (ART) if positive human immunodeficiency virus (HIV+). Eighty-six participants (mean age 47 years, standard deviation 13)...
Introduction Clinical reports of multicentric Castleman disease (MCD) from sub‐Saharan Africa (SSA) are scarce despite high prevalence HIV and Kaposi sarcoma‐associated herpesvirus (KSHV). Our objective is to describe characteristics survival for HIV‐associated MCD patients in Malawi. To our knowledge, this the first case series region. Methods We HIV‐positive with Lilongwe, compare them lymph node sarcoma (KS) non‐Hodgkin lymphoma (NHL) treated at centre. All were enrolled into a...
Common variable immunodeficiency (CVID) is associated with an increased risk of gastric cancer. The aim the study was to determine morphological features CVID-associated adenocarcinoma (CAGA) and background gastritis. population cancer patients CVID Mayo Clinic in period 2000-2010 studied; 6 cases (2 males, 4 females, average age 47 years, range 26-71 years) were found 5793 period. Each patient underwent resection for which histology slides reviewed. Chronic gastritis variables, CVID-related...
Inflammatory cap polyposis (ICP) is a rare nonneoplastic of the colon unknown etiology that can be confused with prolapse-induced polyps and hyperplastic polyposis. We contribute case ICP from 59-year-old woman who was affected by severe constipation hematochezia. Numerous sessile semipedunculated were found in colon, all whitish fibrin. Histology revealed erosion surface, superficial dilated crypts filled mucoid inflammatory exudate, minimal crypt serration, findings typical ICP. Only...
Extranodal NK/T-cell lymphoma (ENKTCL) reports from sub-Saharan Africa (SSA) are remarkably rare, despite early childhood acquisition and high prevalence of the causative infectious agent, Epstein-Barr virus (EBV), frequent occurrence other lymphoproliferative disorders causally associated with EBV. At a national teaching hospital in Malawi, three patients African descent were seen ENKTCL between 2013 2014. Patients aged 29 60 years, two craniofacial involvement one primary abdominal tumor,...
Introduction: Sézary syndrome (SS) is an uncommon form of cutaneous T cell lymphoma (CTCL) with a classical triad lymphadenopathy, characteristic circulating cells (Sézary cells) and erythrodermatous skin involvement mycosis fungoides (MF)‐like histological picture. Case report: A 32‐year‐old woman presented this triad; however, her involvement, histologically, was in the folliculotropic MF, rather than usual MF. Conclusions: In vast majority cases, SS resembles conventional histologically....
Background Fine needle aspiration cytology (FNAC) has been widely accepted to be a safe, accurate, prompt and inexpensive procedure for diagnosis of both neoplastic infectious diseases in adult pediatric populations. Despite its value diagnosis, FNAC is underutilized resource limited countries. We reviewed the utilization after it was introduced at Kamuzu Central Hospital (KCH). Methods A retrospective review all performed KCH laboratory during period January 2012 July 2014 conducted using...
Rosai-Dorfman Disease (RDD) is a rare lymphoproliferative disease with limited cases reported in sub-Saharan Africa, potentially due to lack of pathological services throughout the region. RDD diagnosis can be difficult, especially resource-limited setting, as symptoms nearly identical more common causes lymphadenopathy.
Abstract 2 Background: Breast cancer mortality is high in sub-Saharan Africa (SSA) partly due to limited breast awareness and challenges early detection. We trained laywomen promote perform screening - clinical exam (CBE) urban clinics. This the first study Malawi, SSA assess CBE delivered by with other health services. Methods: Four were deliver educational talks conduct CBE. After training, was implemented diverse Women eligible undergo ≥30 years, no prior or surgery, clinic attendance for...
View this table: Table 1. Laboratory infrastructure ![Figure 1.][1] Figure workflow. ![Figure 2.][1] 2. volume. View Diagnostic concordance Conflict-of-interest disclosure: No competing financial interests
7565 Background: Prognostic factors for diffuse large B-cell lymphoma (DLBCL) in sub-Saharan Africa (SSA) are unknown. We report mature data from one of the first prospective DLBCL cohorts treated under real-world conditions SSA. Methods: Patients ≥18 years with newly diagnosed were enrolled Malawi 2013 to 2017. Participants CHOP chemotherapy, and concurrent antiretroviral therapy (ART) if HIV+. Results: 86 participants mean age 47 (SD 13). 54 (63%) male, 51 (59%) HIV+, whom 34 (67%) on ART...