A5090550616- Alzheimer's disease research and treatments
- Neonatal Respiratory Health Research
- Energy and Environment Impacts
- Air Quality and Health Impacts
- Tryptophan and brain disorders
- Medical Imaging and Pathology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Noise Effects and Management
Dong-A University
2022
Rationale: Neuroinflammation is a primary feature of Alzheimer's disease (AD), for which an increasing number drugs have been specifically developed. The present study aimed to define the therapeutic impact specific subpopulation T cells that can suppress excessive inflammation in various immune and inflammatory disorders, namely, CD4+CD25+Foxp3+ regulatory (Tregs). Methods: To generate Aβ antigen-specific Tregs (Aβ+ Tregs), 1-42 peptide was applied vivo subsequent vitro splenocyte culture....
Particulate matter (PM), a component of air pollution, has been epidemiologically associated with variety diseases. Recent reports reveal that PM detrimental effects on the brain. In this study, we aimed to investigate biological ambient particles neurodegenerative disease Parkinson's (PD). We exposed mice coarse (PM10: 2.5-10 μm) for short (5 days) and long (8 weeks) durations via intratracheal instillation. Long-term PM10 exposure exacerbated motor impairment dopaminergic neuron death in...
Idiopathic pulmonary fibrosis (IPF) is a devastating and common chronic lung disease that pathologically characterized by the destruction of architecture accumulation extracellular matrix in lung. Previous studies have shown an association between surfactant protein (SP) pathogenesis IPF, as demonstrated mutations altered expression SP patients with IPF. However, role development poorly understood. In this study, A (SP-A) was explored experimental induced low or high dose bleomycin (BLM)...