A5025079536- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Prostate Cancer Treatment and Research
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Genomic variations and chromosomal abnormalities
- Cancer Cells and Metastasis
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- DNA Repair Mechanisms
Washington University in St. Louis
2023
Dana-Farber Cancer Institute
2018-2022
Broad Institute
2018-2020
Androgen receptor (AR) signaling is the central driver of prostate cancer across disease states. While androgen deprivation therapy (ADT) effective in initial treatment cancer, resistance to ADT or next-generation pathway inhibitors invariably arises, most commonly through re-activation AR axis. Thus, orthogonal approaches inhibit advanced are essential. Here, via genome-scale CRISPR-Cas9 screening, we identify protein arginine methyltransferase 1 (PRMT1) as a critical mediator expression...
ABSTRACT Androgen receptor (AR) signaling is the central driver of prostate cancer across disease states. While androgen deprivation therapy (ADT) effective in initial treatment cancer, resistance to ADT or next-generation pathway inhibitors invariably arises, most commonly through re-activation AR axis. Thus, orthogonal approaches inhibit advanced are essential. Here, via genome-scale CRISPR/Cas9 screening, we identify protein arginine methyltransferase 1 (PRMT1) as a critical mediator...