A5047030982- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Musculoskeletal pain and rehabilitation
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Cancer survivorship and care
- COVID-19 and Mental Health
- Diabetes Management and Education
- Pain Management and Opioid Use
- Total Knee Arthroplasty Outcomes
- Radio Frequency Integrated Circuit Design
- S100 Proteins and Annexins
- Childhood Cancer Survivors' Quality of Life
- Advanced Neuroimaging Techniques and Applications
- Histone Deacetylase Inhibitors Research
- Advanced MRI Techniques and Applications
- Digital Platforms and Economics
- Mindfulness and Compassion Interventions
- Advanced Radiotherapy Techniques
- Genetics and Neurodevelopmental Disorders
- Biochemical effects in animals
- ICT Impact and Policies
- Inflammatory mediators and NSAID effects
Massachusetts General Hospital
2018-2025
Harvard University
2018-2025
Athinoula A. Martinos Center for Biomedical Imaging
2018-2025
Korea Advanced Institute of Science and Technology
2024-2025
Korea University
2011-2024
National Cancer Center
2011-2023
Oklahoma State University
2023
National Research Foundation of Korea
2018
University of Ulsan
2018
Chung-Ang University
2018
Fibromyalgia (FM) is a poorly understood chronic condition characterized by widespread musculoskeletal pain, fatigue, and cognitive difficulties. While mounting evidence suggests role for neuroinflammation, no study has directly provided of brain glial activation in FM. In this study, we conducted Positron Emission Tomography (PET) using [11C]PBR28, which binds to the translocator protein (TSPO), upregulated activated microglia astrocytes. To enhance statistical power generalizability,...
The COVID-19 pandemic caused by SARS-CoV-2 has triggered a consequential public health crisis of post-acute sequelae (PASC), sometimes referred to as long COVID. mechanisms the heterogeneous persistent symptoms and signs that comprise PASC are under investigation, several studies have pointed central nervous vascular systems being potential sites dysfunction. In current study, we recruited individuals with diverse symptoms, examined relationship between neuroinflammation circulating markers We used [
Gulf War Illness (GWI) is a chronic disorder affecting approximately 30% of the veterans who served in 1991 War. It characterised by constellation symptoms including musculoskeletal pain, cognitive problems and fatigue. The cause GWI not definitively known but exposure to neurotoxicants, prophylactic use pyridostigmine bromide (PB) pills, and/or stressors during deployment have all been suspected play some pathogenic role. Recent animal models suggested that neuroinflammatory mechanisms may...
Patients with schizophrenia (SCZ) experience chronic cognitive deficits. Histone deacetylases (HDACs) are enzymes that regulate circuitry; however, the role of HDACs in disorders, including SCZ, remains unknown humans. We previously determined HDAC2 mRNA levels were lower dorsolateral prefrontal cortex (DLPFC) tissue from donors SCZ compared controls. Here we investigated relationship between vivo HDAC expression and impairment patients matched healthy controls using [11C]Martinostat...
We recently showed that patients with different chronic pain conditions (such as low back pain, fibromyalgia, migraine and Gulf War illness) demonstrated elevated brain and/or spinal cord levels of the glial marker 18-kDa translocator protein (TSPO), which suggests neuroinflammation might be a pervasive phenomenon observable across multiple aetiologically heterogeneous disorders. Interestingly, spatial distribution this neuroinflammatory signal appears to exhibit degree disease specificity...
Abstract Age- and sex-related alterations in gene transcription have been demonstrated, however the underlying mechanisms are unresolved. Neuroepigenetic pathways regulate brain. Here, we measure vivo expression of epigenetic enzymes, histone deacetylases (HDACs), across healthy human aging between sexes using [ 11 C]Martinostat positron emission tomography (PET) neuroimaging ( n = 41). Relative HDAC increases with age cerebral white matter, correlates age-associated disruptions matter...
ObjectiveThis study is aimed at evaluating the attitude and knowledge about optimal use of opioids finding out barriers to cancer pain management especially for young doctors in South Korea.
Chronic pain and mood disorders share common neuroanatomical substrates involving disruption of the reward system. Although increase in negative affect (NA) decrease positive (PA) are well-known factors complicating clinical presentation chronic patients, our understanding mechanisms underlying interaction between PA/NA remains limited. Here, we used a validated task probing behavioral neural responses to monetary rewards losses conjunction with functional magnetic resonance imaging (fMRI)...
Since the COVID-19 pandemic, mental health challenges among children and adolescents in South Korea have intensified with rising rates of depression suicide. Proactive interventions focusing on well-being are needed to address this critical issue. This study examines effectiveness Mindfulness-based Social–Emotional Growth (MSEG) program for enhancing elementary school students Korea. quasi-experimental evaluated impact MSEG at an Gyeonggi-do, A total 70 (35 from lower grades [grades 1–3] 35...
Abstract Our group has shown that translocator protein (TSPO) levels, a putative marker of neuroinflammation, are increased in the brain and spinal cord patients with chronic low back pain (cLBP). Whether neuroinflammation might be therapeutic target for this condition is unknown. In phase II double-blind, placebo-controlled, randomized clinical trial, we sought to evaluate whether tetracycline antibiotic minocycline, which commonly used as glial inhibitor preclinical models, an effect on...
Abstract Introduction: As breast cancer survivorship rises, addressing the long-term side effects of and its treatment is crucial. Chemotherapy has been linked to neuroinflammation, leading cognitive neurological impairments. However, other treatments (e.g., surgery, endocrine therapy) or related conditions pain, progression) may impact neuroinflammation as well. Methods: This cross-sectional study used Siemens 3T integrated positron emission tomography-magnetic resonance imaging (PET/MRI)...
Abstract Using positron emission tomography, we recently demonstrated elevated brain levels of the 18 kDa translocator protein (TSPO), a glial activation marker, in chronic low back pain (cLBP) patients, compared to healthy controls (HCs). Here, first sought replicate original findings an independent cohort (15 cLBP, 37.8 ± 12.5 y/o; HC, 48.2 12.8 y/o). We then trained random forest machine learning algorithms based on TSPO imaging features combining discovery and replication cohorts...
Abstract The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are not fully understood. Both genetic environmental factors contribute to risk BD, which may be linked through epigenetic mechanisms, including those regulated by histone deacetylase (HDAC) enzymes. This study measures in vivo HDAC expression individuals with BD for first time using HDAC-specific radiotracer [ 11 C]Martinostat. Eleven participants age- sex-matched control (CON) completed a...
Abstract The weak association between disability levels and “peripheral” (ie, knee) findings suggests that central nervous system alterations may contribute to the pathophysiology of knee osteoarthritis (KOA). Here, we evaluated brain metabolite in patients with KOA, before after total arthroplasty (TKA), using 1H-magnetic resonance spectroscopy (MRS). Thirty-four presurgical KOA 13 healthy controls were scanned a PRESS sequence (TE = 30 ms, TR 1.7 seconds, voxel size 15 × mm). In addition,...
This cross-sectional study evaluated a convenience sample comprising 182 ovarian cancer survivors to identify symptom clusters according the survivorship stage and determine their effects on quality of life using European Organization for Research Treatment Cancer Quality Life-C30 -OV28 questionnaires. Factor multiple regression analyses were performed that affected in each stage, respectively. Participants acute, extended, permanent survival stages accounted 33%, 36.3%, 30.7% subjects,...