A5065439548- Antibiotic Resistance in Bacteria
- Cystic Fibrosis Research Advances
- Bacterial biofilms and quorum sensing
- Infections and bacterial resistance
- Antibiotics Pharmacokinetics and Efficacy
- Renal Diseases and Glomerulopathies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pneumonia and Respiratory Infections
- Antimicrobial Peptides and Activities
- Middle East Politics and Society
- Marine Ecology and Invasive Species
- Middle East and Rwanda Conflicts
- Microbial Fuel Cells and Bioremediation
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Use and Resistance
- Microbial infections and disease research
- Liver Disease Diagnosis and Treatment
- Plant Virus Research Studies
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- Connective Tissue Growth Factor Research
- Multiculturalism, Politics, Migration, Gender
- Subterranean biodiversity and taxonomy
- Gout, Hyperuricemia, Uric Acid
- Burkholderia infections and melioidosis
Primary Health Care
2023
UCLouvain
2015-2022
Université Libre de Bruxelles
2022
American University of Beirut
2012-2015
Laboratoire de Neurobiologie Cellulaire et Moléculaire
2011
Every model species requires its own developmental table. Astyanax mexicanus, a teleost fish comprising both sighted river and blind cave populations, is becoming more important in the field of evolutionary biology. As such, staging table increasingly necessary, particularly since comparative analysis early events widely employed by researchers. We collected freshly spawned embryos from surface Pachón cavefish populations. Embryos were imaged every 10–12 min during first day development,...
ABSTRACT Pseudomonas aeruginosa is a major cause of morbidity and mortality in cystic fibrosis patients. This study compared the antimicrobial susceptibilities 153 P. isolates from United Kingdom (UK) ( n = 58), Belgium 44), Germany 51) collected 118 patients during routine visits over period 2006 to 2012. MICs were measured by broth microdilution. Genes encoding extended-spectrum β-lactamases (ESBL), metallo-β-lactamases, carbapenemases detected PCR. Pulsed-field gel electrophoresis...
Abstract The β-lactam antibiotic temocillin (6-α-methoxy-ticarcillin) shows stability to most extended spectrum β-lactamases, but is considered inactive against Pseudomonas aeruginosa . Mutations in the MexAB-OprM efflux system, naturally occurring cystic fibrosis (CF) isolates, have been previously shown reverse this intrinsic resistance. In present study, we measured activity a large collection (n = 333) of P. CF isolates. 29% isolates had MICs ≤ 16 mg/L (proposed clinical breakpoint for...
Achromobacter genus (including xylosoxidans, the most prevalent species in patients with cystic fibrosis) is poorly susceptible to conventional antibiotics. Contribution of efflux by AxyABM, AxyXY-OprZ, and AxyEF-OprN target mutations were studied clinical isolates A. xylosoxidans insuavis. Forty-one longitudinally collected from 21 CF whole-genome sequencing (WGS)-typing, determination minimum inhibitory concentrations (MICs) β-lactams, aminoglycosides, colistin, azithromycin,...
Diabetic nephropathy (DN), the leading cause of end-stage renal failure, is clinically manifested by albuminuria and a progressive decline in glomerular filtration rate. The risk factors mechanisms that contribute to development progression DN are still incompletely defined. To address involvement bradykinin B2-receptors (B2R) DN, we used genome wide approach study effects diabetes on differential gene expression profile wild type B2R knockout (B2R−/−) mice. Diabetes was induced with...
Diabetic nephropathy (DN) is the main cause of morbidity and mortality in diabetes characterized by mesangial matrix deposition podocytopathy, including podocyte loss. The risk factors mechanisms involved pathogenesis DN are still not completely defined. In present study, we aimed to understand cellular through which activation B2 kinin receptors contribute initiation progression DN. Stimulation cultured rat podocytes with bradykinin (BK) resulted a significant increase ROS generation, this...
Development of novel therapeutics to treat antibiotic-resistant infections, especially those caused by ESKAPE pathogens, is urgent. One the most critical pathogens P. aeruginosa, which able develop a large number factors associated with antibiotic resistance, including high level impermeability. Gram-negative bacteria are protected from environment an asymmetric Outer Membrane primarily composed lipopolysaccharides (LPS) at outer leaflet and phospholipids in inner leaflet. Based on...
Introduction: Hyperuricemia is a medical condition associated with an increased incidence of comorbidities. Guidelines for the treatment asymptomatic hyperuricemia remain controversial. Several studies have reported that allopurinol overused worldwide. In Qatar, no national guidelines management or previous evaluated over prescription. The study aimed to determine frequency overtreatment and investigate factors. Methods: retrospective cross-sectional was conducted in Qatar on adult patients...