A5056624036- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Inflammatory Biomarkers in Disease Prognosis
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Retinoids in leukemia and cellular processes
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Molecular Biology Techniques and Applications
- Lipid metabolism and biosynthesis
- Polyomavirus and related diseases
- Fatigue and fracture mechanics
- Chromatin Remodeling and Cancer
- RNA Interference and Gene Delivery
- DNA Repair Mechanisms
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Nanoparticle-Based Drug Delivery
Gaozhou People's Hospital
2015-2023
Southern Medical University
2013-2015
Long non-coding RNAs (lncRNAs) play a critical role in cancer progression, including nasopharyngeal carcinoma (NPC). However, it is still poorly understood whether lncRNA regulates epithelial to mesenchymal transition (EMT) and radioresistance of NPC cells. We found that NEAT1 was significantly upregulated cell lines tissues. Knockdown could sensitize cells radiation vitro. Further investigation regulated by modulating EMT phenotype. Furthermore, we there reciprocal repression between...
Abnormal expression of long non-coding RNA often contributes to unrestricted growth cancer cells. Long XIST is upregulated in several cancers; however, its modulatory mechanisms have not been reported hepatocellular carcinoma. In this study, we found that was significantly increased carcinoma tissues and cell lines. promoted cycle progression from the G1 phase S protected cells apoptosis, which contributed growth. addition, revealed there reciprocal repression between miR-139-5p. PDK1...
// Longmei Cai 1,* , Jinbang Li Xiaona Zhang 1, 4,* Yaoyong Lu 5,* Jianguo Wang 1 Xiaoming Lyu 3 Yuxiang Chen Jinkun Liu 2 Hongbing Ying Xin Cancer Research Institute, Southern Medical University, Guangzhou 510515, China School of Chinese Traditional Medicine, Central Laboratory, The Third Affiliated Hospital, 4 Sixth Hospital Sun Yat-Sen 510655, 5 Department Radiation Oncology, Gaozhou People's 525200, * These authors contributed equally. Correspondence to: Li, e-mail: xinli268@gmail.com...
Aim: To study the role of circRNA (circ_0001730) in glioblastoma. Materials & methods: The interaction between circ_0001730 and miR-326 was confirmed by FISH, RNA pull down, RNA-binding protein immunoprecipitation luciferase reporter assays. Cell proliferation growth were determined MTT, EdU colony formation migration assessed Boyden assay. Results: levels elevated glioblastoma cell lines tissues. downregulation suppressed cells. SP1 bounds to promoter host gene EPHB4 thereby increasing...
Aberrant EVI1 expression is frequently reported in cancer studies; however, its role nasopharyngeal carcinoma (NPC) has not been examined detail. The aim of the present study to investigate involvement progression and prognosis NPC. RT-PCR, immunohistochemistry western blot assays were used examine NPC tissues cell lines. Fluorescence situ hybridization assay was amplification tissues. biological effect determined by both vitro vivo studies. dual-luciferase reporter performed confirm that...
MicroRNA (miRNA) are endogenous non-coding RNAs that suppress gene expression at the transcriptional, post-transcriptional or translational level by targeting 3'-UTRs of specific mRNAs. miR-10a has been frequently reported to be aberrantly overexpressed in human tumors. In gastric cancer (GC), an important role metastasis from primary GC lymph nodes. However, and relevant pathways remain largely unknown. The present study was performed using 41 20 normal mucosa tissues. Reverse...
This study aimed to investigate the prognostic value of Onodera's nutritional index (PNI) in patients with metastatic nasopharyngeal carcinoma (NPC).A total 187 NPC treated cisplatin-based chemotherapy were retrospectively reviewed. The PNI was calculated using following formula: serum albumin level (gram per liter) +0.005× peripheral lymphocyte count (per cubic millimeter). A receiver operating characteristics curve for overall survival (OS) highest Youden determined calculate best cutoff...
Abstract Abnormal expression of miR‐224 has been reported to promote cancer progression. However, the role is seldom in oral squamous cell carcinoma (OSCC). We that was significantly down‐regulated OSCC tissues and lines. Restoration decreased growth invasion. In addition, luciferase Western blot assays revealed ADAM17 protein a downstream target miR‐224. The overexpression dismissed miR‐224’s effect on concluded inhibited invasion through regulating expression. Subsequently, we c‐jun...
Lipid remodeling regulators are now being investigated as potential therapeutic targets for cancer therapy a result of their involvement, which includes promoting cellsâ adaptation to the restricted environment. Lysophosphatidylcholine acyltransferases (LPCATs, LPCAT1-4) enzymes that regulate bio-membranes. The functions these in largely unknown. In current study, we found genes belonging LPCAT family participated tumor advancement and were strongly linked dismal prognosis many different...