A5049201964- Computational Drug Discovery Methods
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Nanoparticle-Based Drug Delivery
- HER2/EGFR in Cancer Research
- Advanced Drug Delivery Systems
- Cancer Research and Treatments
- Blood transfusion and management
- Cancer Cells and Metastasis
- Mathematical Biology Tumor Growth
- 3D Printing in Biomedical Research
- Nanoparticles: synthesis and applications
- Advanced Biosensing Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Melanoma and MAPK Pathways
SINTEF
2017-2022
Although nanotoxicology has become a large research field, assessment of cytotoxicity is often reduced to analysis one cell line only. Cytotoxicity nanoparticles complex and should, preferentially, be evaluated in several lines with different methods on multiple nanoparticle batches. Here we report the toxicity poly(alkyl cyanoacrylate) 12 after synthesizing analyzing 19 batches that variations were obtained when using or various assays. Surprisingly, found intermediate degradation rates...
While there is a high interest in drug combinations cancer therapy, openly accessible datasets for combination responses are sparse. Here we present dataset comprising 171 pairwise of 19 individual drugs targeting signal transduction mechanisms across eight cell lines, where the effect each and reported as viability assessed by metabolic activity. Drugs chosen their capacity to specifically interfere with well-known mechanisms. Signalling processes targeted include PI3K/AKT, NFkB, JAK/STAT,...
Abstract Drug combinations have been proposed to combat drug resistance, but putative treatments are challenged by low bench-to-bed translational efficiency. To explore the effect of cell culture format and readout methods on identification synergistic in vitro, we studied response 21 clinically relevant standard planar (2D) layouts physiologically more spheroid (3D) cultures HCT-116, HT-29 SW-620 cells. By assessing changes viability, confluency size, were able identify readout-...
Poly (alkyl cyanoacrylate) (PACA) polymeric nanoparticles (NPs) are promising drug carriers in delivery. However, the selection of commercially available alkyl cyanoacrylate (ACA) monomers is limited, because most were designed for use medical and industrial glues later repurposed encapsulation. This study therefore aimed to seek out novel ACA materials NP systems using a toxicity led screening approach. A multistep strategy, including cytotoxicity alcohols as degradation products PACA (44...