A5024146903- Neonatal and fetal brain pathology
- Heart Rate Variability and Autonomic Control
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Vagus Nerve Stimulation Research
- Non-Invasive Vital Sign Monitoring
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Stress Responses and Cortisol
- Pregnancy and preeclampsia studies
- Maternal Mental Health During Pregnancy and Postpartum
- ECG Monitoring and Analysis
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Infant Health and Development
- Anesthesia and Neurotoxicity Research
- Preterm Birth and Chorioamnionitis
- Nicotinic Acetylcholine Receptors Study
- Cardiac Arrest and Resuscitation
- Renal function and acid-base balance
- Hemodynamic Monitoring and Therapy
- Phonocardiography and Auscultation Techniques
- Immune Response and Inflammation
University of Washington
2016-2025
Université de Montréal
2014-2024
Klinikum rechts der Isar
2022-2024
Klinik für Frauenheilkunde
2024
Olgahospital
2024
Centre Hospitalier Universitaire Sainte-Justine
2012-2023
Drexel University
2022-2023
Seattle University
2017-2022
Precision for Medicine (United States)
2022
Technical University of Munich
2022
Experimental studies that are relevant to human pregnancy rely on the selection of appropriate animal models as an important element in experimental design. Consideration strengths and weaknesses any model disease is fundamental effective meaningful translation preclinical research. Studies sheep have made significant contributions our understanding normal abnormal development fetus. As a pregnancy, enabled scientists clinicians answer questions about etiology treatment poor maternal,...
The processing of ECG signal provides a wealth information on cardiac function and overall cardiovascular health. While multi-lead recordings are often necessary for proper assessment rhythms, they not always available or practical, example in fetal applications. Moreover, wide range small non-obtrusive single-lead ambulatory monitoring devices now available, from which heart rate variability (HRV) other health-related metrics derived. Proper beat detection classification abnormal rhythms is...
Necrotizing enterocolitis (NEC) is an acute neonatal inflammatory disease that affects the intestine and may result in necrosis, systemic sepsis multisystem organ failure. NEC 5-10% of all infants with birth weight ≤ 1500 g or gestational age less than 30 weeks. Chorioamnionitis (CA) main manifestation pathological inflammation fetus strongly associated NEC. CA 20% full-term pregnancies up to 60% preterm and, notably, often occult finding. Intrauterine exposure stimuli switch innate immunity...
Neuroinflammation in utero may contribute to brain injury resulting life-long neurological disabilities. The pivotal role of the efferent cholinergic anti-inflammatory pathway (CAP) controlling inflammation, e.g., by inhibiting HMGB1 release, via macrophages' α7 nicotinic acetylcholine receptor (α7nAChR) has been described adults, but its importance fetus is unknown. Moreover, it unknown whether CAP also exert effects on anatomically predominant afferent component vagus nerve.We measured...
Vagus nerve stimulation (VNS) has been used since 1997 for treatment of drug-resistant epilepsy. More recently, an off-label use VNS explored in animal models and clinical trials a number conditions involving the innate immune system. The underlying premise notion cholinergic antiinflammatory pathway (CAP), mediated by vagus nerves. While macroanatomic substrate - is understood, physiology pleiotropic effects "language" nerve, brain-body communication, remain enigma. Tackling this kind...
Objective. Neuroinflammation in utero may result life-long neurological disabilities. The molecular mechanisms whereby microglia contribute to this response remain incompletely understood. Methods. Lipopolysaccharide (LPS) or saline were administered intravenously non-anesthetized chronically instrumented near-term fetal sheep model inflammation vivo. Microglia then isolated from vivo LPS and (naïve) exposed animals. To mimic the second hit of neuroinflammation, these re-exposed vitro....
Fetal inflammatory response occurs during chorioamnionitis, a frequent and often subclinical inflammation associated with increased risk for brain injury life-lasting neurologic deficits. No means of early detection exist. We hypothesized that systemic fetal without septic shock will be reflected in alterations heart rate (FHR) variability (fHRV) distinguishing baseline versus states.
In the pregnant mother and her fetus, chronic prenatal stress results in entrainment of fetal heartbeat by maternal heartbeat, quantified index (FSI). Deep learning (DL) is capable pattern detection complex medical data with high accuracy noisy real-life environments, but little known about DL's utility non-invasive biometric monitoring during pregnancy. A recently established self-supervised (SSL) approach to DL provides emotional recognition from electrocardiogram (ECG). We hypothesized...
There is a need for affordable, widely deployable maternal-fetal ECG monitors to improve maternal and fetal health during pregnancy delivery. Based on the diffusion-based channel selection, here we present mathematical formalism clinical validation of an algorithm capable accurate separation from two signal acquired over abdomen. The proposed first algorithm, best authors' knowledge, focusing analysis based abdominal signal, apply it publicly available databases, PhysioNet non-invasive fECG...
Abstract Background Maternal stress before, during and after pregnancy has profound effects on the development lifelong function of infant’s neurocognitive development. We hypothesized that programming central nervous system (CNS), hypothalamic–pituitary–adrenal (HPA) axis autonomic (ANS) induced by prenatal (PS) is reflected in electrophysiological epigenetic biomarkers. In this study, we aimed to find noninvasive biomarkers PS newborn salivary DNA. Results A total 728 pregnant women were...
Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities. Astrocytes microglia, among the brain's non-neuronal "glia" cell populations, play a pivotal role in neurodevelopment predisposition initiation of disease throughout lifespan. One most common neurodevelopmental disorders manifesting between 1-4 years age is autism spectrum disorder (ASD). A pathological glial-neuronal interplay thought increase risk for clinical manifestation ASD at-risk...
ABSTRACT Cardiotocography (CTG), introduced in the 1960s, was initially expected to prevent hypoxia‐related deaths and neurological injuries. However, more than five decades later, evidence supporting of intrapartum CTG preventing neonatal long‐term childhood morbidity mortality remains inconclusive. At same time, shortcomings interpretation have been recognised as important contributory factors rising caesarean section rates missed opportunities for timely interventions. An limitation is...
Reduced birth weight predisposes to cardiovascular diseases in later life. We examined fetal sheep at 0.76 ( n = 18) and 0.87 17) gestation whether spontaneously occurring variations affect maturation of autonomic control function. Fetal weights both gestational ages were grouped statistically low (LW) normal (NW) P < 0.01). LW fetuses within the span showing minor growth dysproportionality favouring heart brain, with a primary carcass between 0.05). While twins largely contributed...