A5090226722- Polymer Surface Interaction Studies
- Supramolecular Self-Assembly in Materials
- Electrospun Nanofibers in Biomedical Applications
- Dialysis and Renal Disease Management
- Blood properties and coagulation
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Mast cells and histamine
- Advanced Drug Delivery Systems
- Bone Tissue Engineering Materials
- Connective tissue disorders research
- Advanced Glycation End Products research
- Gold and Silver Nanoparticles Synthesis and Applications
- Graphene and Nanomaterials Applications
- Protein Interaction Studies and Fluorescence Analysis
- Neonatal and fetal brain pathology
- Advanced Sensor and Energy Harvesting Materials
- Monoclonal and Polyclonal Antibodies Research
- Iron Metabolism and Disorders
- Glaucoma and retinal disorders
- Molecular Junctions and Nanostructures
- Advanced biosensing and bioanalysis techniques
- Polydiacetylene-based materials and applications
- Biochemical effects in animals
- Antimicrobial Peptides and Activities
University of Alberta
2016-2025
University of Calgary
2016-2021
National Institute for Nanotechnology
2011-2020
King Saud University
2020
Alberta Hospital Edmonton
2020
National Research Council Canada
2011-2016
Natural Sciences and Engineering Research Council
2015
Institute of Nanotechnology
2014
Zero to Three
2012
Massachusetts Institute of Technology
2006-2009
The release kinetics for a variety of proteins wide range molecular mass, hydrodynamic radii, and isoelectric points through nanofiber hydrogel scaffold consisting designer self-assembling peptides were studied by using single-molecule fluorescence correlation spectroscopy (FCS). In contrast to classical diffusion experiments, the approach allowed direct determination coefficients lysozyme, trypsin inhibitor, BSA, IgG both inside after being released into solution. results FCS analyses...
Nonspecific protein adsorption generally occurs at the biomaterial−tissue interface and usually has adverse consequences. Thus, surfaces that are protein-resistant eagerly sought with expectation these materials will exhibit improved biocompatibility. Surfaces modified end-tethered poly(ethylene oxide) (PEO) have been shown to be some degree. Although mechanisms unclear, it suggested chain length, density, conformation important factors. To investigate effects of PEO we selected a model...
A clear understanding of the mechanisms responsible for protein-resistant nature end-tethered poly(ethylene oxide) (PEO) surfaces remains elusive. barrier to improved is fact that many factors involved (chain length, chain density, hydration, conformation, and distal chemistry) are inherently correlated. We hypothesize that, by comparing systems variable but precisely known it should be possible gain additional insight into effects other factors. To evaluate this hypothesis,...
In the present study, first, Fe3O4 nanoparticles were functionalized using glutaric acid and then composited with CQDs. Doxorubicin (DOX) drug was loaded to evaluate performance of nanocomposite for targeted delivery applications. The XRD pattern confirmed presence characteristic peaks CQDs Fe3O4. FTIR spectrum, carboxyl functional groups on Fe3O4/CQDs observed; DOX (positive charge) is onto (negative by electrostatic absorption. FESEM AFM images showed that particle sizes 23–75 1–3 nm,...
Abstract Plant wearable detection has garnered significant interest in advancing agricultural intelligence and promoting sustainable food production amidst the challenges of climate change. Accurately monitoring plant health agrochemical residue levels necessitates qualities such as precision, affordability, simplicity, noninvasiveness. Here, a novel attachable plasmonic film is introduced designed for on‐site residues utilizing surface‐enhanced Raman spectroscopy (SERS). By functionalizing...
ABSTRACT When the kidneys are injured, uremic toxins (UTXs) accumulate in body, affecting other tissues and causing a loss of essential body functions. This study investigated adsorption blood plasma‐laden UTXs on surface PCL fibers to assess their potential as an alternative membrane dialysis materials. Using plasma containing 26 at concentration similar that found end‐stage kidney disease patients, we analyzed adsorbed proteins examined clot formation normal toxin‐treated presence fibers....
Despite its medical applications, the mechanisms responsible for osseointegration of bioactive glass (45S5) have yet to be fully understood. Evidence suggests that strongest predictor glasses, and ceramics, with bone tissue as formation an apatitic calcium phosphate layer atop implanted material, osteoblasts being main mediator new formation. Most tried understand this layer, other bioresponses between host 45S5 using Simulated Body Fluid; a solution containing ion concentrations similar...
The electrospun nanofiber membrane has demonstrated great potential for wound management due to its porous structure, large surface area, mechanical strength, and barrier properties. However, there is a need develop transparent bioactive nanofibers with strong properties facilitate the monitoring of healing process. In this study, we present an electrospinning-based method creating (∼80–90%), (∼11–13 MPa), Janus membranes. innovative square pattern architecture includes thin hydrophobic...
Nonfouling polymer architectures are considered important to the successful implementation of many biomaterials. It is thought that how these polymers induce conformational changes in proteins upon adsorption may dictate fate device being utilized. Herein, oxidized silicon nanoparticles (SiNP) were modified with various forms poly(carboxybetaine methacrylamide) (PCBMA) for express purpose understanding chemistry affects film hydration, adsorbed protein conformation, and clot formation...
Ionic self-complementary peptides are considered an important class of self-assembling peptides. In particular, RADARADARADARADA (RADA4) is well-known to form a relatively regular nanofiber structure that has been primarily studied in terms its physicochemical properties, as related biomedical applications. However, the molecular level interactions involved promoting self-assembly this peptide into nanofibers have not fully elucidated. Herein, thermodynamic analysis influences chemistry upon...