A5084581926- Boron Compounds in Chemistry
- Radiopharmaceutical Chemistry and Applications
- Cholesterol and Lipid Metabolism
- Hormonal Regulation and Hypertension
- Orthopedic Infections and Treatments
- Biochemical and Molecular Research
- Infectious Diseases and Tuberculosis
- Orthopaedic implants and arthroplasty
- Cancer Diagnosis and Treatment
- Thermal Regulation in Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Solubulity and Delivery Systems
- Bone and Joint Diseases
- Atherosclerosis and Cardiovascular Diseases
- Traumatic Brain Injury and Neurovascular Disturbances
- Nuclear Physics and Applications
- Bone health and treatments
- Computational Drug Discovery Methods
- Click Chemistry and Applications
- Phagocytosis and Immune Regulation
- Steroid Chemistry and Biochemistry
- Eicosanoids and Hypertension Pharmacology
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
BioVinc (United States)
2017-2019
University of Missouri
2015-2018
South College
2015
Osteomyelitis is a major problem worldwide and devastating due to the potential for limb-threatening sequelae mortality. pathogens are bone-attached biofilms, making antibiotic delivery challenging. Here we describe novel osteoadsorptive bisphosphonate-ciprofloxacin conjugate (BV600022), utilizing “target release” chemical strategy, which demonstrated significantly enhanced therapeutic index versus ciprofloxacin treatment of osteomyelitis in vivo. In vitro antimicrobial susceptibility...
A class of cyclodextrin (CD) dimers has emerged as a potential new treatment for atherosclerosis; they work by forming strong, soluble inclusion complexes with oxysterols, allowing the body to reduce and heal arterial plaques. However, characterizing interactions between CD oxysterols presents formidable challenges due low sterol solubility, synthesis modified CDs resulting in varying number position molecular substitutions, diversity interaction mechanisms. To address these illuminate...
Abstract: Our previous study indicated that overexpression of nicotinamide phosphoribosyltransferase (NAMPT) aggravated acute lung injury, while knockdown NAMPT expression attenuated ventilator-induced injury. Recently, we found meta-carborane-butyl-3-(3-pyridinyl)-2E-propenamide (MC-PPEA, MC4), in which the benzoylpiperidine moiety FK866 has been replaced by a carborane, displayed 100-fold increase inhibition over FK866. Here, determined effects MC4 and on cecal ligation puncture (CLP)...
Our previous study indicated that carborane containing small-molecule 1-(hydroxymethyl)-7-(4'-(trans-3″-(3'″-pyridyl)acrylamido)butyl)-1,7-dicarbadodecaborane (hm-MC4-PPEA), was a potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt). Nampt has been shown to be upregulated in most cancers and is promising target for the treatment many different types cancers, including breast cancers.To increase selectivity hm-MC4-PPEA toward cancer cells, three prodrugs were synthesized with...
A class of cyclodextrin (CD) dimers has emerged as a potential new treatment for atherosclerosis; they work by forming strong, soluble inclusion complexes with oxysterols, allowing the body to reduce and heal arterial plaques. However, characterizing interactions between CD oxysterols presents formidable challenges due low sterol solubility, synthesis modified CDs resulting in varying number position molecular substitutions, diversity interaction mechanisms. To address these illuminate...
Cardiovascular disease (CVD) is the world’s biggest killer. Current treatments for CVD are failing to deliver on promises beat this deadly and complex family of diseases. New approaches that go beyond targeting LDL needed. Cyclarity Therapeutics has developed a novel class specifically engineered, dimerized cyclodextrin (CD) molecules encapsulation toxic oxidized cholesterol. Oxidized cholesterol accumulates over time causes dysfunction in many cell types, linking it several age-related...