A5079360452- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Mosquito-borne diseases and control
- Vector-borne infectious diseases
- Rabies epidemiology and control
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- HIV Research and Treatment
- Cell Adhesion Molecules Research
- Calcium signaling and nucleotide metabolism
- Bacillus and Francisella bacterial research
- Monoclonal and Polyclonal Antibodies Research
- Barrier Structure and Function Studies
- HIV-related health complications and treatments
- Autophagy in Disease and Therapy
- Cellular transport and secretion
- Malaria Research and Control
- Diffusion and Search Dynamics
- Immune Response and Inflammation
- Poxvirus research and outbreaks
- Lipid Membrane Structure and Behavior
- Escherichia coli research studies
- Cellular Mechanics and Interactions
- Viral Infections and Vectors
Université Paris Cité
2024
Institut Pasteur
2024
Institut Curie
2012-2020
Inserm
2012-2020
Université Paris Sciences et Lettres
2020
EMBL Australia
2020
UNSW Sydney
2020
ARC Centre of Excellence in Advanced Molecular Imaging
2020
Immunité et Cancer
2017
Abstract The immune response relies on the migration of leukocytes and their ability to stop in precise anatomical locations fulfil task. How leukocyte function are coordinated is unknown. Here we show that immature dendritic cells, which patrol environment by engulfing extracellular material, cell antigen capture antagonistic. This antagonism results from transient enrichment myosin IIA at front, disrupts back-to-front gradient motor protein, slowing down locomotion but promoting capture....
Lysosomes control dendritic cell migration by linking macropinocytosis to cytoskeletal rearrangement via the TFEB-TRPML1 axis.
HIV-1–infected macrophages likely represent viral reservoirs, as they accumulate newly formed virions in internal virus-containing compartments (VCCs). However, the nature and biogenesis of VCCs remain poorly defined. We show that upon HIV-1 infection primary human macrophages, Gag is recruited to preexisting containing scavenger receptor CD36, which then become VCCs. Silencing CD36 decreases amount released. Strikingly, soluble anti-CD36 antibodies, but not natural ligands inhibit release...
Systemic infections leading to sepsis are life-threatening conditions that remain difficult treat, and the development of innovative therapies is hampered by limitations current experimental models. Animal models constrained species-specific differences, while 2D cell culture systems fail capture complex pathophysiology infection. To overcome these limitations, we developed a laser photoablation-based, three-dimensional microfluidic model meningococcal vascular colonization, human-specific...