Objectives Persons at high risk of rheumatoid arthritis (RA) might benefit from a low-risk pharmacological intervention aimed primary prevention. Previous studies demonstrated disease-modifying effects statins in patients with RA as well an association between statin use and decreased development. A randomised, double-blind, placebo-controlled trial investigated whether atorvastatin could prevent development high-risk individuals. Methods Arthralgia anticitrullinated protein antibody (ACPA)...

Objective It has been suggested that rheumatoid arthritis (RA) may originate at the oral mucosa. The aim of present study was to assess microbiome and periodontal condition in patients with early RA individuals risk developing compared healthy controls. Methods Three groups were recruited (n = 50 participants per group): 1) (meeting American College Rheumatology/European Alliance Associations for Rheumatology 2010 classification criteria), 2) (those arthralgia who positive RA‐associated...

Rheumatoid factors (RF) are one of the hallmark autoantibodies characteristic rheumatoid arthritis (RA), and frequently observed in other diseases healthy individuals. RFs comprise multiple subtypes with different specificities towards constant region human IgG. Studies indicate that these patterns differ between naturally occurring associated disease. However, individual either have not been clearly defined.In this study, we developed an extended set engineered IgG-fragment crystallisable...

Objectives Several trials to test the efficacy of a pharmacological intervention aimed at primary prevention rheumatoid arthritis (RA) are ongoing or have recently been completed. A common issue in these is severe difficulty with patient recruitment. In order enhance recruitment, this qualitative study identified barriers and facilitators individuals risk RA participate trial. Methods Individuals developing (ie, arthralgia anticitrullinated protein antibodies and/or factor without...

Low-grade inflammation and metabolic syndrome are seen in many chronic diseases, including rheumatoid arthritis (RA) osteoarthritis (OA). Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects improving outcomes patients with other diseases or increased risk thereof, especially cardiovascular disease. For RA syndrome-associated OA (MSOA), whole food plant-based diets (WFPDs) promising results. A WFPD, however, had not yet been combined...

Rheumatoid arthritis (RA) is characterised by the presence of autoantibodies, among which those targeting constant region immunoglobulin G (IgG), called rheumatoid factors (RF). Despite this link, RFs can also be found in other disorders and healthy population, hampers its use as a diagnostic tool. We recently showed that subset RA-derived target distinct epitope on IgG-Fc, feature currently not used clinic.

Rheumatoid arthritis (RA) is associated with an increased cardiovascular disease (CVD) risk which may start even before diagnosis. To explore this CVD prior to RA, we determined multiple factors and two 10-year clinical scores in a cohort of individuals at-risk RA. We also analyzed associations development autoantibody status compared subset age sex matched seronegative control group.In 555 consecutive arthralgia patients positive for rheumatoid factor (RF) / or anti-citrullinated protein...

According to guidelines, clinical arthritis is mandatory for diagnosing RA. However, in the absence of synovitis, imaging-detected subclinical synovitis increasingly used instead and considered as a starting point DMARD therapy. To search evidence we studied natural course arthralgia patients with from three longitudinal cohorts determined frequencies non-progression clinically apparent inflammatory (IA) (i.e. 'false positives').

Abstract Background Individuals at risk of developing rheumatoid arthritis (RA) may benefit from lifestyle or pharmacological interventions aimed primary prevention. The same apply to individuals axial spondyloarthritis (axSpA). Our aim was investigate and compare the willingness RA axSpA rheumatologists initiate preventive intervention. Methods (arthralgia anti-citrullinated protein antibodies and/or factor positivity without (RA-risk cohort; n = 100)), (first-degree relatives...

Objective Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated with rheumatoid arthritis (RA), also found in other diseases and healthy individuals. RFs bind to various epitopes the constant (Fc‐) domain of IgG. Therefore, disease‐specific reactivity patterns may exist. This study was undertaken order develop a new approach dissecting RF epitope binding across different diseases. Methods We analyzed serum from patients seropositive arthralgia, RA, primary Sjögren’s...

There is a need to better define symptom characteristics associated with arthritis development in individuals at risk of rheumatoid (RA). We investigated whether reported symptoms at-risk could predict and predictive differed between seropositive seronegative individuals.At-risk from four cohorts (Netherlands, UK, Sweden, Switzerland) completed the Symptoms Persons At Risk Rheumatoid Arthritis (SPARRA) questionnaire. Participants had either (i) anti-citrullinated protein antibodies and/or...

Abstract Objectives To evaluate oral health-related quality of life (OHRQoL) in early rheumatoid arthritis (ERA) patients and individuals at risk (RA) compared to healthy controls, explore possible associated factors. Materials methods Fifty ERA patients, 50 at-risk individuals, age gender matched controls were recruited. OHRQoL (Oral Health Impact Profile-14 (OHIP-14)); number decayed, missing, filled teeth (DMFT); denture use; periodontal inflamed surface area (PISA); xerostomia...

<h3>Background</h3> Primary prevention may be possible in subjects at high risk to develop rheumatoid arthritis (RA). We designed a placebo controlled randomized trial investigate if atorvastatin can halt RA development persons for this disease (STAPRA, Netherlands Trial Register NTR5265). A statin was chosen because these drugs reduce activity (1), hyperlipidemia patients on statins have lower developing (2) and dyslipidemia increased the seropositive arthralgia cohort (3). assumed that...

Background: Persons at high risk for developing rheumatoid arthritis (RA) may benefit from a low-risk pharmacological intervention aimed primary prevention. Statins are safe and widely-used drugs; previous studies demonstrated disease-modifying effects of statins in RA patients 1 as well an association between statin use decreased development 2 . Objectives: We designed multi-center, randomized, double-blind, placebo-controlled trial to investigate if atorvastatin 3 years could prevent...

Objective To investigate the performance and factors of influence optical spectral transmission (OST) imaging as a new technique for measuring joint inflammation in rheumatoid arthritis (RA).Method OST was performed 24 RA patients 37 controls. Mann–Whitney U-test used to assess differences score between Receiver operating characteristics (ROC), linear regression generalized estimating equations analysis were discriminative capability association with clinical disease parameters, ultrasound,...

The aim of the current study was to explore changes in lipid and NT-proBNP levels rheumatoid arthritis (RA) patients through different phases disease: from pre-clinical stage RA onset up treatment phase with biological disease-modifying anti-rheumatic drugs (bDMARDS).

Background: Accurate prediction of rheumatoid arthritis (RA) development in persons at risk RA can help to select individuals for early intervention trials. Currently, mostly relies on biomarkers such as genetic factors, autoantibodies and imaging abnormalities, with symptoms being only a minor component 1-3 . However, at-risk exhibit high prevalence diverse often severe 4,5 information the predictive ability individual or symptom complexes is still largely lacking. Objectives: We...

Background: The HLA shared epitope (SE) and smoking are the best known genetic environmental risk factors for rheumatoid arthritis (RA) development; however, at which pre-RA stage they exert their effect is unknown. following stages discerned: an asymptomatic in autoimmune responses can develop, a symptomatic (clinically suspect arthralgia (CSA)), development of clinically apparent inflammatory (IA). Studies general population revealed contrasting results on associations between SE-alleles...

Background: Persons at risk of developing rheumatoid arthritis (RA) may benefit from lifestyle 1 or pharmacological 2 intervention aimed primary prevention. Although less studied, the same apply to persons increased axial spondyloarthritis (axSpA) 3 . Patients’ perceptions and physicians’ views have an important influence on patients’ willingness use treatment as previously shown in axSpA. Objectives: Our aim was investigate compare individuals at-risk RA axSpA rheumatologists initiate...

<h3>Background</h3> Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease associated with an increased cardiovascular (CV) risk that already present at the time of diagnosis. However, it unclear what point in period before diagnosis RA CV increases. Therefore, we assessed 10 year morbidity and mortality cohort subjects for analysed associations anti-citrullinated protein antibody (ACPA) status development. <h3>Methods</h3> In 594 consecutive arthralgia patients positivity...