A5014589613- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac Fibrosis and Remodeling
- Electrospun Nanofibers in Biomedical Applications
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Pelvic and Acetabular Injuries
- Nanoparticles: synthesis and applications
- Atrial Fibrillation Management and Outcomes
- Blood properties and coagulation
- Fault Detection and Control Systems
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Magnesium Alloys: Properties and Applications
- Neurological Disorders and Treatments
- Viral Infections and Immunology Research
- Hip and Femur Fractures
- Platelet Disorders and Treatments
- Shoulder and Clavicle Injuries
- Congenital Heart Disease Studies
- Traditional Chinese Medicine Analysis
- COVID-19 Clinical Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Receptor Mechanisms and Signaling
Beijing Tian Tan Hospital
2018-2025
Capital Medical University
2018-2025
Guangxi University
2024
Fourth Affiliated Hospital of Guangxi Medical University
2002-2024
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2024
Dalian University of Technology
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2022
Xi'an Jiaotong University
2022
Peking University
2013-2021
Guangxi Medical University
2018-2021
Rapid cut-off of blood supply in diseases involving thrombosis is a major cause morbidity and mortality worldwide. However, the current thrombolysis strategies offer limited results due to therapeutics' short half-lives, low targeting ability, unexpected bleeding complications. Inspired by innate roles platelets hemostasis pathological thrombus, platelet membrane-camouflaged polymeric nanoparticles (nanoplatelets) are developed for delivery thrombolytic drug, recombinant tissue plasminogen...
Tao Guo, MD; Yongzhen Fan, Ming Chen, Xiaoyan Wu, Lin Zhang, He, Hairong Wang, Jing Wan, Xinghuan Zhibing Lu, MD
Danshensu, the effective ingredient of plant Salvia miltiorrhiza (Danshen), has been widely used for treatment cardiovascular diseases. Cardiac fibrosis is an important process in pathological cardiac remodeling and leads to heart failure. We investigated effect Danshensu on β-adrenergic receptor (β-AR)-mediated involved signaling transduction. inhibited cardiofibroblast proliferation collagen I synthesis induced by isoproterenol (ISO), a selective β-AR agonist. Phosphorylation p38...
Cardiac fibrosis is a common feature of advanced coronary heart disease and characteristic disease. However, currently available drugs against cardiac are still very limited. Here, we have assessed the role isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxylpropanoate (IDHP), new metabolite Danshen Dripping Pills, in mediated by β-adrenoceptor agonist, isoprenaline, its underlying mechanisms.Identification IDHP was identified mass spectrometry, proton carbon nuclear magnetic resonance spectra....
Gold nanoparticles (GNPs) are attracting more and attention for their great potential value in biomedical application. Currently, no study has been reported on the chronic cardiac toxicity of GNPs after repeated administration. Here we carried out a comprehensive evaluation to heart. Polyethylene glycol (PEG) -coated at three different sizes (10, 30 50 nm) or PBS was administrated mice via tail vein 14 consecutive days. Then were euthanized 2 weeks, 4 weeks 12 first injection. The...
During long-term antiplatelet agents (APAs) administration, patients with thrombotic diseases take a fairly high risk of life-threatening bleeding, especially when in need urgent surgery. Rapid functional reversal APAs remains an issue yet to be efficiently resolved by far due the lack any specific agent clinic, which greatly restricts use APAs.Flow cytometry analysis was first applied assess dose-dependent activity platelet-mimicking perfluorocarbon-based nanosponges (PLT-PFCs) toward...
Abstract The severe bleeding complications of long‐term antiplatelet therapy limit its broader application in the treatment or prevention thrombosis‐associated diseases. This risk is particularly serious when facing emergency surgeries where rapid restoration normal platelet function required. Timely reversal effects agents becomes crucial such scenarios. Despite widespread use clopidogrel and prasugrel for their potent activity, absence specific effective remains a notable challenge....
Gold nanoparticles (AuNPs) are widely used for drug delivery because of their unique biological properties, such as safety and ability to prolong action. Some studies have demonstrated that AuNPs accumulate in the heart, especially during pathological processes. Therefore, it is very important understand effect on heart. Myocardial infarction (MI) a major cause morbidity mortality; however, MI remains unclear. In present study, we carried out comprehensive evaluation acute MI. The results...
Abstract Purpose To evaluate the short-term clinical efficacy and advantages of surgery robot positioning system for insertion Femoral Neck System (FNS) in treatment femoral neck fractures. Methods The data 52 patients with fracture (FNF) who had been treated FNS between June 2020 September 2021 were retrospectively analyzed. Among them, 26 traditional (control group), while additional assisted by an orthopaedic (study group). operation duration, frequency key-guide needle placement,...
β-adrenergic receptors (β-ARs) play an important role in cardiac remodeling, which is the key pathological process various heart diseases and leads to failure. However, regulation of β-AR expression remodeling hearts still unclear. This study aims clarify possible mechanisms underlying β1- β2-AR remodeling. The rat model was established by subcutaneous injection isoproterenol(ISO) at dose 0.25 mg·kg−1·d−1 for 7days. We found that β2-ARs decreased heart. may include inhibition DNA...
Serum uric acid (SUA) is associated with left ventricular hypertrophy in a wide spectrum of study population. However, whether this association exists patients hypertrophic cardiomyopathy (HCM, including obstructive HCM), and if present, gender has any impact on association, remains unknown.A total 161 HCM (age 47.2 ± 10.8 years, 99 (62 %) men) were included study. All underwent extensive clinical, laboratory, echocardiographic, cardiac magnetic resonance (CMR) imaging examinations. Left...
For a moving target indicating (MTI) radar system to eliminate "blind speeds" or synthetic aperture (SAR) ranges," two more pulse repetition intervals (PRIs) are often used sequentially. This article proposes new correlation-matching algorithm estimate the PRIs, despite receiver possibly missing some time samples. proposed operates in orthonormal Ramanujan subspace, leading fewer nonzero elements therein, thus reducing computational load. employs l <sub...
Abstract A biological template strategy is implemented for the fabrication of hollow noble metal composite nanospheres within ordered array nanostructures by introducing butterfly wings to some convenient technique procedure. Butterfly are activated ethylenediamine increase reactive sites on chitin component, which Ag nanoparticles in situ formed and serve as “seeds” direct further incorporation during following impregnation could function bio-substrate provide an regulate synthesis process...
The activation of β-adrenergic receptors (β-ARs) plays a key role in regulating cardiac function. However, the detailed regulatory mechanisms β-AR-induced fibrosis are still unclear. We used proteomics approach to analyze changes protein expression patterns with β-AR stimulation. HIP-55 (also called debrin-like; DBNL) was revealed as novel regulator signaling network activation. Further studies both HIP-55-overexpressed and -deficient fibroblasts indicated that negatively regulated...
The purpose of this meta-analysis is to compare the efficacy and safety aspirin rivaroxaban in prevention venous thromboembolism (VTE) following either total knee arthroplasty or hip arthroplasty.A comprehensive literature search several electronic databases (PubMed, Embase, Web Science) was conducted identify relevant studies. Outcomes interest included VTE rate, deep vein thrombosis (DVT) pulmonary embolism major bleeding events, mortality blood transfusion, wound complication. Risk ratio...
The aim of this study was to explore the most updated changing trends non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed age-standardized rates (ASRs) prevalence, incidence, disability-adjusted life-years (DALYs), mortality nrCAVD from 1990 2019 using data Global Burden Disease (GBD) 2019. relations between ASRs socio-demographic index (SDI) were with Pearson’s correlation coefficients. Decomposition frontier analysis employed contribution...
Purpose To compare the characteristics of magnetic resonance perfusion-weighted imaging (MRPWI) scans before and after transcatheter arterial chemoembolization (TACE) treatment hepatocellular carcinoma (HCC) to apply MRPWI in evaluating therapeutic effect TACE prognosis HCC. Materials methods Thirty-five patients with HCC undergoing their first were enrolled this study. T2WI, T1WI, PWI MRI performed 24–48 h 48–168 TACE. Perfusion parameters calculated maximum slope used create a time–signal...
Cardiac remodeling is the pathological basis of various cardiovascular diseases. In this study, we found gender-related differences in β-adrenergic receptor (AR)-mediated cardiac remodeling. model was established by subcutaneous injection isoprenaline (ISO) for 14 days. Heart rate (HR), mean arterial pressure (MAP), and echocardiography were obtained on 7th 14th days during ISO administration. Myocardial cross-sectional area ratio heart mass to tibia length (HM/TL) detected assess...