Objective Peritoneal dialysis (PD) has become more prevalent as a treatment modality for end-stage renal disease, and peritonitis remains one of its most devastating complications. The aim the present investigation was to examine frequency predictors impact on clinical outcomes. Methods Our retrospective observational cohort study enrolled 391 patients who had been treated with continuous ambulatory PD (CAPD) at least 90 days. Relevant demographic, biochemical, data were collected an...

Background and objectives Mean corpuscular volume is the measure of average size circulatory erythrocyte, it principally used as an index for differential diagnosis anemia. Recently, mean has been associated with mortality in many clinical settings. However, association patients CKD not fully addressed. Design, setting, participants, & measurements We conducted a retrospective observational cohort study 1439 stages 3–5 baseline values from 2004 to 2012 medical center. The was divided...

Abstract Nonalcoholic fatty liver disease (NAFLD) is an important risk factor for the development of type 2 diabetes mellitus. Interferon gamma-induced protein 10 (IP-10), a proinflammatory chemokine, plays crucial role in inflammatory diseases. This cross-sectional pilot study investigated whether circulating IP-10 associated with progression and prediabetes patients NAFLD. A total 90 NAFLD alone (n = 48) or incident 42) 43 controls participated this study. Fasting plasma was used to assess...

In Taiwan, Changhua County residents were exposed to high heavy metal pollution and exhibited levels in blood urine. We examined associations between metals residential soil renal outcomes of with chronic kidney disease (CKD).From 1 January 2003 30 June 2015, we retrospectively identified CKD patients an estimated glomerular filtration rate <60 mL/min per 1.73 m2 at one tertiary care centre. linked data displaying concentrations from farm adjacent the patients' residences clinical outcomes....

Background: Taiwan has the highest incidence of end-stage renal disease (ESRD) in world. The epidemiologic features ESRD, however, have not been investigated. In this case–control study, we evaluated risk ESRD associated with a number putative factors.Methods: We studied 200 patients among whom had newly diagnosed between 1 January 2005 and 31 December 2005; controls were selected from relatives treated general surgery unit. Using structured questionnaire, collected information related to...

Aims: Metabolic syndrome (MetS) is characterized by a group of defects metabolic origin which are possibly involved in mitochondrial DNA (mtDNA) alteration mtDNA content [Lee et al. Exp Biol Med, 2007; 232(5):592-606]. The present study was undertaken to ascertain whether leukocyte copy number related MetS.Methods: Eighty non-MetS subjects and 50 with MetS were recruited. leukocytes from each measured using quantitative polymerase chain reaction.Results: significantly lower than that...

Metabolic factors are major risk for non-alcoholic fatty liver disease although other may also contribute to development of disease. We explored the association between exposure soil heavy metals and prevalence disease.We retrospectively analysed data from patients diagnosed with in 2014 at Health Evaluation Centre Chang-Hua Christian Hospital (n=1137). used residency provided records metal concentrations a nationwide survey conducted by Environmental Protection Administration Taiwan....

Objective We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine matched controls without in this large-scale retrospective cohort study. Design Population-based Setting 8880 503 070 were enrolled January 1, 2000 December 31, 2013, all diagnosed to be disease. All participants registered National Health Insurance Research Database. Participants Finally, data from 7156 propensity-score-matched control analysed. Primary outcome measure used...

Background and objectives Hydroxychloroquine is widely used in patients with rheumatoid arthritis. However, large-scale studies examining the long-term effects of hydroxychloroquine on development kidney disease arthritis are lacking. We aimed to assess association use risk developing CKD this population. Design, setting, participants, &amp; measurements conducted an observational cohort study for newly diagnosed who were enrolled prospectively Taiwan’s National Health Insurance Research...

Chronic kidney disease (CKD) is a significant global health problem associated with high morbidity and mortality rates. Traditional Chinese Medicine (TCM) utilizes tongue diagnosis to differentiate symptoms predict prognosis. This study examines the relationship between characteristics CKD severity using an automatic system (ATDS), which captures images non-invasively provide objective diagnostic information. cross-sectional, case-control was conducted from July 1, 2019, December 31, 2021....

Renal fibrosis is a common outcome in many progressive renal diseases. Unilateral ureteral obstruction (UUO) known to induce oxidative stress and inflammation the kidneys, leading development of fibrosis. Fermented strawberry (Fragaria x ananassa Duch.) possesses antioxidant properties; however, its effect on remains unclear. This study aimed evaluate impact fermented dry powder (FSP) by assessing proinflammatory cytokines, markers, underlying mechanisms. Male Sprague-Dawley rats were...

Introduction Hot flashes have been postulated to be linked systemic inflammation. This study aimed investigate the relationship between hot flashes, pro-inflammatory factors, and leukocytes in healthy, non-obese postmenopausal women. Participants design In this cross-sectional study, a total of 202 women aged 45–60 years were stratified into one four groups according their hot-flash status: never experienced (Group N), mild m), moderate M), severe S). Variables measured included clinical...

Objective Anemia is associated with high mortality and poor prognosis after acute coronary syndrome (ACS). Increased red cell distribution width (RDW) a strong independent predictor for adverse outcomes in ACS. The common underlying mechanism anemia increased RDW value iron deficiency. It not clear whether serum deficiency without affects left ventricular (LV) performance primary angioplasty myocardial infarction (AMI). We investigated the prognostic of concentration on LV ejection fraction...

Abstract This study investigated the interaction effects of meteorological factors and air pollutants on onset acute coronary syndrome (ACS). Data ACS patients were obtained from Taiwan Full Spectrum Registry comprised 3164 with a definite date during period October 2008 January 2010 at 39 hospitals. Meteorological conditions pollutant concentrations locations 488-day obtained. Time-lag Poisson logistic regression used to explore their association incidence. One-day lag atmospheric pressure...

This study aimed to determine the prognostic value of mutations in tumor suppressor gene FBXW7 for clinical outcomes colorectal cancer (CRC).Between January 2000 and December 2009, tissues from 1,519 CRC patients at Taipei Veterans General Hospital were assessed using a MassArray system. We compared clinicopathological variables prognosis between wild-type mutant tissue groups.FBXW7 present 114/1,519 (7.5%). In stage I/II patients, was more common than (62.3% vs. 50.8%). with did not differ...

Introduction Hot flashes have been postulated to be linked the development of metabolic disorders. This study aimed evaluate relationship between hot flashes, adipocyte-derived hormones, and insulin resistance in healthy, non-obese postmenopausal women. Participants design In this cross-sectional study, a total 151 women aged 45–60 years were stratified into one three groups according hot-flash status over past months: never experienced (Group N), mild-to-moderate M), severe S). Variables...

There is little information about the association between stroke and kidney diseases. We aimed to investigate impact of on long-term renal outcomes.In this large population-based retrospective cohort study, we identified 100,353 subjects registered in National Health Insurance Research Database Taiwan from January 1, 2000, through December 31, 2012, including 33,451 patients 66,902 age-, sex- Charlson's comorbidity index score-matched controls.The incidence rate chronic disease (CKD) was...

We studied the combined effect of air pollutant concentrations and meteorological factors [e.g., temperature atmospheric pressure (AP)] on acute exacerbation coronary obstructive pulmonary disease (COPD) in 277 older patients with COPD (240 men 37 women; average age, 75.3 ± 9.3 years). Average concentrations, AP, temperature, relative humidity corresponding to each 7 days before date hospitalisation were identified as case two other weekly averages, 4 8 weeks prior admission, considered...

Sleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of on health outcomes remains unclear. This study evaluated relationships between inflammation women.This cross-sectional enrolled 281 healthy aged 45 60 years. The Pittsburgh Quality Index (PSQI) was used measure sleep. Multiplex assays were levels 9 cytokines morning fasting plasma samples. Other variables measured this included clinical characteristics...

Peritonitis rate has been reported to be associated with technique failure and overall mortality in previous literatures. However, information on the impact of timing first peritonitis episode continuous ambulatory peritoneal dialysis (CAPD) patients is sparse. The aim this research study influence time clinical outcomes, including failure, patient dropout from (PD).A retrospective observational cohort was conducted over 10 years at a single PD unit Taiwan. A total 124 CAPD least one...

Recently, accumulating evidence has demonstrated that RDW independently predicts clinically important outcomes in many populations. However, the role of not been elucidated chronic kidney disease (CKD) patients. We conducted present study with aim to evaluate predictive value CKD patients.A retrospective observational cohort 1075 stage 3-5 patients was a medical center. The patients' baseline information included demographic data, laboratory values, medications, and comorbid conditions....

Yes-associated protein (YAP) is a transcriptional coactivator in the Hippo pathway that regulates cell proliferation, differentiation, and apoptosis. The MEK5/ERK5 MAPK cascade essential for early step of myogenesis. In this study, we generated C2C12 stable lines expressed YAP (C2C12-YAP cells) found ERK5 MEK5 were activated C2C12-YAP cells compared with control (C2C12-vector) cells. C2C12YAP also differentiated into myotubes better than C2C12-vector cells, elevated levels myogenin,...

Urothelial carcinoma (UC) is the ninth most prevalent malignancy worldwide. Noninvasive and efficient biomarkers with high accuracy are imperative for surveillance diagnosis of UC. CKD patients were enrolled as a control group in this study discovery highly specific urinary protein markers An iTRAQ-labeled quantitative proteomic approach was used to discover novel potential markers. These further validated 501 samples by ELISA assay, their diagnostic accuracies compared those other reported...