A5036087100- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Diabetes and associated disorders
- Microbial Metabolic Engineering and Bioproduction
University of California, San Diego
2019-2022
Mitochondria are dynamic organelles that must precisely control their protein composition according to cellular energy demand. Although nuclear-encoded mRNAs can be localized the mitochondrial surface, importance of this localization is unclear. As yeast switch respiratory metabolism, there an increase in fraction cytoplasm mitochondrial. Our data point change volume increasing certain surface mitochondria. We show mRNA necessary and sufficient production levels required during growth....
During times of unpredictable stress, organisms must adapt their gene expression to maximize survival. Along with changes in transcription, one conserved means regulation during conditions that quickly repress translation is the formation cytoplasmic phase-separated mRNP granules such as P-bodies and stress granules. Previously, we identified distinct steps can be coupled glucose starvation promoter sequences nucleus are able direct subcellular localization translatability mRNAs cytosol....
Mitochondria are dynamic in their size and morphology yet must also precisely control protein composition according to cellular energy demand. This is particularly complicated for mitochondria, as they coordinate gene expression from both the nuclear mitochondrial genome. We have found that cells able use this post-transcriptionally with metabolic demands of cell through enhanced mRNA localization mitochondria. As yeast switch respiratory metabolism, increase volume fraction is, ratio...
During times of unpredictable stress, organisms must adapt their gene expression to maximize survival. Along with changes in transcription, one conserved means regulation during conditions that quickly represses translation is the formation cytoplasmic phase-separated mRNP granules such as P-bodies and stress granules. Previously, we identified distinct steps can be coupled glucose starvation promoter sequences nucleus are able direct subcellular localization translatability mRNAs cytosol....