A5058669809- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Epilepsy research and treatment
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Drug Transport and Resistance Mechanisms
- Transcranial Magnetic Stimulation Studies
- Trace Elements in Health
- Glioma Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- RNA Research and Splicing
- Amyotrophic Lateral Sclerosis Research
- Chemokine receptors and signaling
- Neurotransmitter Receptor Influence on Behavior
- RNA regulation and disease
- Ion channel regulation and function
Karolinska Institutet
2017-2023
Nobel Foundation
2018
Ben-Gurion University of the Negev
2011-2015
Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative disease. Here, we report such and the underlying mechanism sporadic Alzheimer's disease (AD). AD entorhinal cortices presented globally impaired exon exclusions selective loss of hnRNP A/B splicing factors. Supporting functional relevance, knockdown induced alternative impairments dendrite primary neurons, memory electrocorticographic mice. Transgenic mice with disease-associated mutations APP or Tau...
The rodent external globus pallidus (GPe) contains two main neuronal subpopulations, prototypic and arkypallidal cells, which differ in their cellular properties. Their functional synaptic connectivity is largely unknown. Here we studied the membrane properties, inputs, sensory responses of these subpopulations mouse GPe. We performed vivo whole-cell recordings GPe neurons used optogenetic stimulation to dissect afferent inputs from striatum subthalamic nucleus (STN). Both received barrages...
Abstract The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, responses are affected by activity, however, it is not known whether such sensorimotor interactions occur in how they shaped dopamine. To determine impact of activity on striatal processing, we performed vivo whole-cell recordings DLS awake mice during presentation tactile stimuli. Striatal medium spiny neurons (MSNs) were activated whisker stimulation...
Abstract TGF-β1 is a master cytokine in immune regulation, orchestrating both pro- and anti-inflammatory reactions. Recent studies show that whereas induces quiescent microglia phenotype, it plays pathogenic role the neurovascular unit triggers neuronal hyperexcitability epileptogenesis. In this study, we that, primary glial cultures, TGF-β signaling rapid upregulation of IL-6 astrocytes, but not microglia, via enhanced expression, phosphorylation, nuclear translocation SMAD2/3....
Sensory processing is crucial for execution of appropriate behavior. The external globus pallidus (GPe), a nucleus within the basal ganglia, highly involved in control movement and could potentially integrate sensory-motor information. GPe comprises prototypic arkypallidal cells, which receive partially overlapping inputs. It unclear, however, inputs convey sensory information to them. Here, we used vivo whole-cell recordings mouse optogenetic silencing characterize pathways that shape...
Striatal projection neurons, the medium spiny neurons (MSNs), play a crucial role in various motor and cognitive functions. MSNs express either D1- or D2-type dopamine receptors initiate direct-pathway (dMSNs) indirect pathways (iMSNs) of basal ganglia, respectively. dMSNs have been shown to receive more inhibition than iMSNs from intrastriatal sources. Based on these findings, computational modeling striatal network has predicted that under healthy conditions should total input iMSNs. To...
Studying epileptogenesis in a genetic model can facilitate the identification of factors that promote conversion normal brain into one chronically prone to seizures. Synapsin triple-knockout (TKO) mice exhibit adult-onset epilepsy, thus allowing characterization events as preceding or following seizure onset. Although it has been proposed congenital reduction inhibitory transmission is underlying cause for epilepsy these mice, young TKO are asymptomatic. We report lesion exerts long-term...
Summary The rodent external Globus Pallidus (GPe) contains two main neuronal subpopulations, prototypic and arkypallidal cells, which differ in their cellular properties. Their functional synaptic connectivity is, however, largely unknown. Here, we studied the membrane properties inputs to these subpopulations mouse GPe. We obtained vivo whole-cell recordings from identified GPe neurons used optogenetic stimulation dissect afferent striatum subthalamic nucleus (STN). All received barrages of...
Summary The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions is involved in functions. In regions, responses are altered by activity, however, it not known if such sensorimotor interactions also occur the how they modulated dopamine (DA). To determine impact of activity on striatal processing, we performed vivo whole-cell recordings DLS awake mice during presentation tactile stimuli. Striatal medium spiny neurons (MSNs) were activated...
Abstract Striatal projection neurons, the medium spiny neurons (MSNs), play a crucial role in various motor and cognitive functions. MSNs express either D1 or D2 type dopamine receptors initiate direct-pathway (dMSNs) indirect pathways (iMSNs) of basal ganglia, respectively. dMSNs have been shown to receive more inhibition than iMSNs from intrastriatal sources. Based on these findings, computational modelling striatal network has predicted that under healthy conditions should excitatory...