Madeline Drake
A5088763265- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Valve Diseases and Treatments
- Pancreatitis Pathology and Treatment
- Cardiac Structural Anomalies and Repair
- Vascular Procedures and Complications
- Pancreatic and Hepatic Oncology Research
- Central Venous Catheters and Hemodialysis
- Acute Ischemic Stroke Management
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Issues in Pregnancy
- Muscle and Compartmental Disorders
- Family and Disability Support Research
- Macrophage Migration Inhibitory Factor
- Nonmelanoma Skin Cancer Studies
- Diet and metabolism studies
- Cutaneous lymphoproliferative disorders research
- Neurogenetic and Muscular Disorders Research
- Adolescent and Pediatric Healthcare
- Prosthetics and Rehabilitation Robotics
- Adipose Tissue and Metabolism
- Vascular Tumors and Angiosarcomas
- Stroke Rehabilitation and Recovery
Houston Methodist
2023-2024
Methodist Hospital
2023-2024
The University of Texas Health Science Center at Houston
2020-2022
University of Toronto
2012-2021
St Michael’s Hospital
2021
Unity Health Toronto
2021
Texas A&M University
2018
With the growing prevalence and mortality of peripheral arterial disease, preoperative assessment, risk stratification, determining correct indication for endovascular open surgical procedures are essential therapeutic decision-making. The effectiveness interventional is significantly influenced by plaque composition calcification pattern. Therefore, identification patients whom treatment most appropriate solution often remains a challenge. commonly used imaging techniques have their own...
Thoracic aortic aneurysm and dissection are complex diagnoses that require management by multidisciplinary providers using a variety of medical therapies, surgical interventions, lifestyle modifications. Pharmacological agents, such as β-blockers (atenolol) angiotensin II type 1 receptor blockers (losartan), have been mainstay treatments for several years, research from the past decade has continued to evaluate these other medication classes further improve patient morbidity mortality....
Understanding what matters most to patients can help guide research in a direction that is best situated provide evidence responsive their core concerns. This better inform the treatment decision-making process for and physicians. The Aortic Dissection (AD) Collaborative built collaborative AD infrastructure involving other stakeholders facilitate patient-centered outcomes training, support, networking among those affected by AD. Two surveys semi-structured interviews were conducted between...
Chronic pancreatitis (CP) is a major risk factor of pancreatic ductal adenocarcinoma (PDAC). How CP promotes oncogenesis remains unclear. A characteristic feature PDAC its prominent desmoplasia in the tumor microenvironment, composed activated fibroblasts and macrophages. Macrophages can be characterized as M1 or M2, with tumor-inhibiting -promoting functions, respectively. We reported that Gremlin 1 (GREM1), key pro-fibrogenic factor, upregulated stroma CP. The current study aimed to...
For patients with existing venous thromboembolisms (VTEs), anticoagulation remains the standard of care recommended across multiple professional organizations. However, for who developed a deep thrombosis (DVT) and/or pulmonary embolism and cannot tolerate anticoagulation, inferior vena cava (IVC) filters must be considered among other alternative treatments. Although placement filter is low-risk intervention, there are important factors techniques that surgeons interventionalists should...
Recent randomized controlled trials have demonstrated a notable prevalence of immediate technical failures in percutaneous vascular interventions (PVIs) for complex arterial lesions associated with chronic limb-threatening ischemia. Current imaging modalities present inherent limitations identifying these lesions, making it challenging to determine the most suitable candidates PVI. We novel preprocedural magnetic resonance (MRI) histology protocol that might higher rate and midterm PVI failure.
Aortic dissection (AD) is a life-changing event that often accompanied by loss of normal quality life. Survivors AD go on to have chronic disease requires lifestyle modification, medical management, and surgical repair the aorta. Clinical care includes multiple disciplines, health settings, different geographic locations. This qualitative assessment examined experiences people with at risk for AD. The following four themes emerged: "unnecessary drama" diagnosis, unmet needs information...
The Aortic Dissection (AD) Collaborative was established to evaluate patient-centered research priorities in AD. Education identified as a topic of interest by the stakeholders. AD Working Group evaluated existing educational resources and areas amenable comparative effectiveness research. most important positive qualities available education are ease use, diversity representation, accessibility, organization. negative these non-patient-centered language, promotional themes, those with...
Aortic dissection (AD) is a life-threatening rare disease that occurs as spontaneous tear in the wall of aorta. Survivors AD go on to have chronic process requires lifelong follow-up and management. Although COVID-19 pandemic has strained health systems impacted practice United States, effects these impacts people living with or at risk for not well understood. This mixed methods project examined experiences community during between March October 2020. Results reveal lacked clear guidance...
Introduction: Recent studies on peripheral arterial disease (PAD) indicate prevalence of PAD in women to be equally if not greater than men, also suggesting that the latter have poorer outcomes with endovascular treatments. Hypothesis: Sex-related differences treatment may attributed variations within vessel wall. Aims: To evaluate sex-based calcification patterns and lesion characteristics patients. Methods: 35 legs from 34 patients (15 women) undergoing major amputation were collected....
We have previously demonstrated that the pancreas can recover from chronic pancreatitis (CP) lesions in cerulein-induced mouse model. To explore how pancreatic recovery is achieved at molecular level, we used RNA-sequencing (seq) and profiled transcriptomes during CP transition to recovery. was induced by intraperitoneally injecting cerulein C57BL/6 mice. Time-matched controls (CON) were given normal saline. Pancreata harvested mice 4 days after final injections (designated as CON) or weeks...