A5006692713- Phenothiazines and Benzothiazines Synthesis and Activities
- Synthesis and biological activity
- Quinazolinone synthesis and applications
- Multicomponent Synthesis of Heterocycles
- Synthesis and Biological Evaluation
- Computational Drug Discovery Methods
- Malaria Research and Control
- Sulfur-Based Synthesis Techniques
University of Nigeria
2017-2020
The reaction of diaza-5H-benzo[a]phenoxazin-5-one and 5H-benzo[a]phenoxazin-5-one with various phenols catalyzed by Pd/t-BuXPhos/K3PO4 system gave previously unknown ether derivatives (7a-f 8a-f) in good yields. UV-visible, FTIR 1H NMR data were used to confirm structures the synthesized compounds. parent compounds screened in-silico for their drug-likeness binding affinities microbial targets through molecular docking. Molinspiration software AutoDock docking studies respectively.All showed...
In this study, palladium catalyzed cross coupling reaction for the arylation of linear diaza triphenodioxazine is reported.The 2,5-dibromo-1,4-quinone with two molar equivalents 2-amino-3-hydroxypyridine in anhydrous basic medium furnished 1,8diazatriphenodioxazine ( 9) good yield.The non aza analogue and parent ring system was also obtained under similar conditions.6-Bromo-1,8-diazatriphenodioxazine (10) formed by bromination compound 9 glacial acetic acid.Functionalized aryl derivatives...