A5100717286- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Semiconductor materials and devices
- Uterine Myomas and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Integrated Circuits and Semiconductor Failure Analysis
- Advanced Data Storage Technologies
- Engineering Applied Research
- Intraperitoneal and Appendiceal Malignancies
- Advancements in PLL and VCO Technologies
- Advanced Memory and Neural Computing
- Advanced Wireless Communication Techniques
- Sirtuins and Resveratrol in Medicine
- Thin-Film Transistor Technologies
- Cancer Risks and Factors
- Bone health and osteoporosis research
- Semiconductor Lasers and Optical Devices
- Analog and Mixed-Signal Circuit Design
- Potassium and Related Disorders
- Tendon Structure and Treatment
- Wireless Communication Networks Research
- Marine and Coastal Research
- Inflammatory Biomarkers in Disease Prognosis
Boramae Medical Center
2019-2025
Korea National University of Transportation
2025
Seoul Metropolitan Government
2019-2024
Seoul National University
2011-2024
Ewha Womans University
2009-2021
Institute of Ophthalmology
2021
Incheon National University
2020
Yonsei University
2020
Kyung Hee University
2019
Korea Institute of Radiological and Medical Sciences
2014-2017
Abstract Background PHI-101 is an orally available, selective checkpoint kinase 2 (Chk2) inhibitor. has shown anti-tumour activity in ovarian cancer cell lines and impaired DNA repair pathways preclinical experiments. Furthermore, the vivo study suggests synergistic effect of through combination with PARP inhibitors for treatment. The primary objective this to evaluate safety tolerability platinum-resistant recurrent cancer. Methods Chk2 inhibitor Recurrent EpitheliAl periToneal, fallopIan,...
The authors modified the charge decay model of silicon-oxide-nitride-oxide-silicon-type memory at temperatures above 150°C. includes effect internal electric field induced by charges trapped in silicon nitride layer. extracted trap density distributions energy level Si-rich using and compared them with those stoichiometric nitride. It has been revealed that larger shallow than this relation is reversed as goes deeper.
To evaluate the improvement in prognosis prediction with reassignment of International Federation Gynecology and Obstetrics (FIGO) stages for ovarian carcinoma.This was a retrospective study patients epithelial ovarian, fallopian tube, primary peritoneal cancers. Sub-staging criteria used stage were defined as follows: surgical spillage (IC1), capsule rupture before surgery or tumor on surface (IC2), positive cytology results (IC3); microscopic (IIB1) macroscopic (IIB2) pelvic spread;...
Purpose The aim of this study is to evaluate the safety fertility-sparing surgery as treatment for patients with primary mucinous epithelial ovarian cancer. Materials and Methods A retrospective cancer between 1991 2010 was performed. demographics survival outcomes were compared who underwent those radical surgery. Results total 110 At time surgery, tumors appeared be grossly confined ovaries in 90 patients, evidence metastasis definite 20 patients. Of that at surgical exploration, 35...
The purpose of this study was to determine whether chemoradiation (CCR) is efficient for improving prognosis, compared with systemic chemotherapy (SC), in patients stage IVB cervical cancer who have distant lymphatic metastasis.Among 2,322 between January 2000 and March 2010, 43 (1.9%) had disease. After exclusion 19 due insufficient data hematogenous metastasis, 24 (1%) received CCR (n=10) or SC (n=14) were enrolled. We tumor response, progression-free survival (PFS) overall (OS), disease...
This study aimed to investigate the impact of underweight status on prognosis advanced-stage ovarian cancer. A total 360 patients with stage III-IV epithelial cancer were enrolled and divided into three groups by body mass indexes (BMIs): (BMI < 18.5 kg/m 2 ); normal weight overweight (18.5 BMI 27.5 obesity ≥ ). Progression-free survival (PFS), overall (OS), CA-125, neutrophil lymphocyte ratio (NLR) as a marker reflecting host inflammation immunity compared among according treatment...
Endometriosis is a major cause of infertility, and considering its pathophysiology, it expected to affect pregnancy outcomes as well. This study aimed evaluate whether endometriosis associated with adverse after successful conception. Data from singleton deliveries between January 2014 October 2019 were obtained the Korean Health Insurance Review Assessment Service database. We compared clinical characteristics women without endometriosis. A total 1,251,597 pregnant enrolled; these, 32,951...
Colon cancer is the most prevalent type of gastrointestinal cancer, characterized by high incidence and mortality rates despite advancements in diagnosis treatment. Although chemotherapy standard treatment for advanced cases, survival benefits are often limited, highlighting need innovative therapeutic strategies. SH003, an herbal mixture composed Astragalus membranaceus, Angelica gigas, Trichosanthes kirilowii Maximowicz, has demonstrated anticancer properties across various types. This...
Objectives: The aim of this study was to evaluate the surgical outcomes, therapeutic efficacy, and psychological satisfaction Le Fort partial colpocleisis (LFC) procedure, an obliterative treatment option, in elderly women with advanced apical prolapse, based on 20-year experience a single surgeon. Methods: A retrospective cohort conducted 81 aged 60 older who underwent LFC for prolapse at institution from 2006 2025. Baseline characteristics, comorbidities, perioperative complications,...
We investigated the charge decay characteristics of a silicon-oxide-nitride-oxide-silicon type nonvolatile memory at elevated temperatures. Based on amphoteric trap model and thermal emission trapped charge, we propose an advanced which includes effect bottom oxide, apply it to extraction density distribution in energy levels nitride layer. The samples prepared have films deposited simultaneously are classified into two groups according thickness oxide. distributions extracted from showed...
Abstract Background Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in treatment advanced HCC sorafenib. However, many patients with show reduced sensitivity to sorafenib during treatment. SIRT3, a member mammalian sirtuin family, tumor suppressor certain types. few studies have investigated effects SIRT3 on prognosis and HCC. Here, we aimed investigate correlation between expression glucose metabolism...
Infectious mononucleosis due to Epstein-Barr virus (EBV) infection sometimes causes acute hepatitis, which is usually self-limiting with mildly elevated transaminases, but rarely jaundice. Primary EBV in children asymptomatic, a small number of healthy individuals, typically young adults, results clinical syndrome infectious typical symptoms fever, pharyngitis, lymphadenopathy, and hepatosplenomegaly. rather uncommonly confirmed as an etiologic agent hepatitis adults. Here, we report two...
Abstract Background The Laparoscopic Approach to Cervical Cancer trial and Surveillance, Epidemiology, End Results program database study demonstrated that minimally invasive radical hysterectomy was inferior abdominal in terms of disease recurrence survival. Among risk factors related poor prognosis after surgery (MIS), tumour spillage during intracorporeal colpotomy became a significant issue. Thus, we designed this evaluate the efficacy safety using an endoscopic stapler for early-stage...
Purpose:The goal of this study was to identify baseline prognostic factors outcome in ankle osteoarthritis patients after intra-articular hyaluronic acid injection.Materials and Methods: Patients with who received injection therapy were retrospectively reviewed.Each patient weekly injections (2 mL) for 3 weeks.Six predictors including gender, age, symptom duration, radiographic stage, subchondral cyst, fracture history evaluated.Visual analogue scale (VAS) satisfaction evaluated as...
This study aimed to evaluate the prognostic impact of age at diagnosis, and pretreatment hematologic markers, including lymphocyte percentage neutrophil-to-lymphocyte ratio (NLR), in patients with locally advanced cervical cancer (LACC) treated definitive radiotherapy (RT).A total 392 LACC (stage IIb IVa) cisplatin-based concurrent chemoradiotherapy or RT alone between 2001 2012 were retrospectively enrolled. Clinical data complete blood counts extracted from electronic medical records...
There are currently three ongoing studies on less radical surgery in cervical cancer: ConCerv, GOG-278, and SHAPE. The aim of this study was to evaluate the performance criteria used retrospectively suggest a new, simplified criterion microscopic Stage IB1 cancer.A retrospective analysis performed 125 cancer patients who had no clinically visible lesions were allotted based findings after conization. All magnetic resonance imaging (MRI) conization underwent type C2 hysterectomy. We suggested...
Summary Reduction or disruption of the blood supply to bone is involved in pathogenesis osteonecrosis femoral head (ONFH). An altered lipid metabolism one major risk factors for ONFH. Sterol regulatory element binding protein, SREBF1 activates genes regulating biosynthesis. The aim this study was examine association between polymorphisms gene and ONFH susceptibility Korean population. 24 unrelated individuals sequenced two were detected. Two variants, IVS6 − 48 C > T IVS7 + 117 A G,...