A5056730563- vaccines and immunoinformatics approaches
- Health and Medical Studies
- Workplace Health and Well-being
- RNA and protein synthesis mechanisms
- School Health and Nursing Education
- Antimicrobial Peptides and Activities
- Machine Learning in Bioinformatics
- Psychiatric care and mental health services
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Augmented Reality Applications
- Anesthesia and Sedative Agents
- Peptidase Inhibition and Analysis
- Occupational Health and Performance
- French Urban and Social Studies
- Biomedical and Chemical Research
- Protein Structure and Dynamics
- Medical Practices and Rehabilitation
- Immunotherapy and Immune Responses
- German legal, social, and political studies
- Thyroid and Parathyroid Surgery
- Empathy and Medical Education
- Occupational and environmental lung diseases
- Technology and Human Factors in Education and Health
- European Socioeconomic and Political Studies
ETH Zurich
1982-2025
Lawrence Berkeley National Laboratory
2024
IBM Research - Zurich
2021-2023
Joanneum Research
2014-2022
St. Luke's Hospital
2021
University of Freiburg
2019-2020
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit
2017-2019
Klinikum rechts der Isar
2011-2016
University Medical Center Freiburg
2016
Fraunhofer Institute for Interfacial Engineering and Biotechnology
2012
Abstract Motivation The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing TCRs antigenic targets (epitopes), allowing to research missing link between TCR sequence epitope binding specificity. Scarcity data a large space make this task challenging, date only models limited small set epitopes achieved good performance. Here, we...
Many different solutions to predicting the cognate epitope target of a T-cell receptor (TCR) have been proposed. However several questions on advantages and disadvantages these approaches remain unresolved, as most methods only evaluated within context their initial publications data sets. Here, we report findings first public TCR-epitope prediction benchmark performed 23 models in ImmRep 2022 specificity workshop. This revealed that use paired-chain alpha-beta, well CDR1/2 or V/J...
Abstract Packaging of the eight genomic RNA segments influenza A viruses (IAV) into viral particles is coordinated by segment-specific packaging sequences. How signals regulate specific incorporation each segment virions and whether other or host factors are involved in this process unknown. Here, we show that distinct amino acids nucleoprotein (NP) required for segments. This was determined studying NP a bat A-like virus, HL17NL10, context conventional IAV (SC35M). Replacement conserved...
The accurate definition of suitable metastable conformational states is fundamental for the construction a Markov state model describing biomolecular dynamics. Following dimensionality reduction in molecular dynamics trajectory, these microstates can be generated by recently proposed density-based geometrical clustering algorithm [F. Sittel and G. Stock, J. Chem. Theory Comput. 12, 2426 (2016)], which design cuts resulting clusters at energy barriers allows data-based identification all...
Abstract Many different solutions to predicting the cognate epitope target of a T-cell receptor (TCR) have been proposed. However several questions on advantages and disadvantages these approaches remain unresolved, as most methods only evaluated within context their initial publications data sets. Here, we report findings first public TCR-epitope prediction benchmark performed 23 models in ImmRep 2022 specificity workshop. This revealed that use paired-chain alpha-beta, well CDR1/2 or V/J...
Understanding the mechanisms underlying T cell receptor (TCR) binding is of fundamental importance to understanding adaptive immune responses. A better biochemical rules governing TCR can be used, e.g. guide design more powerful and safer cell-based therapies. Advances in repertoire sequencing technologies have made available millions sequences. Data abundance has, turn, fueled development many computational models predict properties TCRs from their Unfortunately, while these works great...
Markov state models represent a popular means to interpret biomolecular processes in terms of memoryless transitions between metastable conformational states. To gain insight into the underlying mechanism, it is instructive determine all relevant pathways initial and final states process. Currently available methods, such as chain Monte Carlo transition path theory, are convenient for identifying most frequented pathways. They less suited account typically huge amount with low probability...
Abstract Deciphering the antigen recognition capabilities by T cell and B receptors (antibodies) is essential for advancing our understanding of adaptive immune system responses. In recent years, development protein language models (PLMs) has facilitated bioinformatic pipelines where complex amino acid sequences are transformed into vectorized embeddings, which then applied to a range downstream analytical tasks. With their success, we have witnessed emergence domain-specific PLMs tailored...
Motivation: The activity of the adaptive immune system is governed by T-cells and their specific T-cell receptors (TCR), which selectively recognize foreign antigens. Recent advances in experimental techniques have enabled sequencing TCRs antigenic targets (epitopes), allowing to research missing link between TCR sequence epitope binding specificity. Scarcity data a large space make this task challenging, date only models limited small set epitopes achieved good performance. Here, we...
My Places Diary is a research prototype, available on Google Play, that tracks places and movements of users throughout the day. It includes two innovative features: Firstly users’ home workplaces are detected automatically, based heuristics derived from earlier work automatic semantic pla
First responders engage in highly stressful situations at the emergency site that may induce stress, fear, panic and a collapse of clear thinking. Staying cognitively under control these circumstances is necessary condition to avoid useless risk-taking particularly provide accurate situation reports organize appropriate support time. This work-in-progress applied flexible virtual reality (VR) training environment investigate performance reporting rather realistically simulated mission...
Natural disasters, industrial accidents, or outbreaks, as evidenced by the COVID-19 pandemic, underscores importance of preparedness in managing immediate evacuation affected individuals. Infectious diseases pose risk compromising transport environment potentially contaminating interior vessel. Addressing this challenge, paper presents DEKO-AirTrans solution introducing development and implementation a mobile system, tailored for use aboard C-130 Hercules aircraft. The system features...
The early retirement of teachers because illness is presently a great social and sociomedical problem. In Bavaria, currently more than every second case in the profession result psychic or psychosomatic illness. aim all preventive measures must therefore be first preservation restoration health teachers. With an underlying comprehensive biopsychosocial understanding performance, should take into consideration both circumstances behaviour, as well pathogenetic salutogenetic aspects disease....