A5013973347- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Dietary Effects on Health
- Genomics, phytochemicals, and oxidative stress
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Biochemical effects in animals
- Liver Disease Diagnosis and Treatment
Joslin Diabetes Center
2014-2023
Emmanuel College - Massachusetts
2022-2023
Harvard University
2014-2019
Harvard Stem Cell Institute
2014-2019
Brown University
2008
Rhode Island Hospital
2008
Alzheimer's disease (AD) is associated with brain insulin resistance and deficiency, whereas Type 2 diabetes mellitus (T2DM) peripheral resistance. This study assesses the degree to which T2DM causes AD-type neurode
Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty (FA), promotes health and longevity. Here, we show that OA benefits Caenorhabditis elegans by activating endoplasmic reticulum (ER)-resident transcription factor SKN-1A (Nrf1/NFE2L1) in homeostasis response. SKN-1A/Nrf1 cleared from ER ER-associated degradation (ERAD) machinery stabilized when proteasome activity low...
The nematode worm Caenorhabditis elegans provides a powerful system for elucidating how genetic, metabolic, nutritional, and environmental factors influence aging. mechanistic target of rapamycin (mTOR) kinase is important in growth, disease, aging present the mTORC1 mTORC2 complexes. In diverse eukaryotes, lifespan can be increased by inhibition mTORC1, which transduces anabolic signals to stimulate protein synthesis inhibit autophagy. Less understood about mTORC2, affects C. complex manner...
Summary Interventions that slow aging and prevent chronic disease may come from an understanding of how dietary restriction (DR) increases lifespan. Mechanisms proposed to mediate DR longevity include reduced mTOR signaling, activation the NAD + ‐dependent deacylases known as sirtuins, in derive higher levels respiration. Here, we explored these hypotheses Caenorhabditis elegans using a new liquid feeding protocol. lifespan extension depended upon group regulators are involved stress...
Abstract Although excessive lipid accumulation is a hallmark of obesity-related pathologies, some lipids are beneficial. Oleic acid (OA), the most abundant monounsaturated fatty (FA), promotes health and longevity. Here we show that OA benefits C. elegans by activating endoplasmic reticulum (ER)-resident transcription factor SKN-1A (Nrf1/NFE2L1) in homeostasis response. SKN-1A/Nrf1 cleared from ER ER-associated degradation (ERAD) machinery stabilized when proteasome activity low, canonically...