A5114277613- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
2024-2025
Instituto de Salud Carlos III
2024-2025
Universidad Politécnica de Madrid
2025
Abstract The identification of non-small cell lung cancer (NSCLC) patients who will benefit from immunotherapy remains a clinical challenge. Monitoring real-world data (RWD) in the first cycles therapy may provide more accurate representation response patterns setting. We propose multivariate Bayesian joint model using generalized linear mixed effects, trained and validated on RWD 424 advanced NSCLC retrospectively collected three centers. Center1 was used as training ( $$N=212$$ <mml:math...
The incorporation of digital pathology in clinical practice will require the training pathologists skills. Our study aimed to assess reliability among determining tumor percentage whole slide images (WSI) non-small cell lung cancer (NSCLC) using image analysis, and how results correlate with molecular findings. Pathologists from nine centers were trained quantify epithelial cells, tumor-associated stromal non-neoplastic cells NSCLC WSI QuPath. Then, we conducted two consecutive ring trials....