A5008939285- Gut microbiota and health
- Drug Transport and Resistance Mechanisms
- Clostridium difficile and Clostridium perfringens research
- Pregnancy and preeclampsia studies
- Arctic and Russian Policy Studies
- Sex and Gender in Healthcare
- RNA Research and Splicing
- Health and Lifestyle Studies
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Neurological disorders and treatments
- Hemoglobinopathies and Related Disorders
- Polar Research and Ecology
- Hemodynamic Monitoring and Therapy
- Iron Metabolism and Disorders
- Social Skills and Education
- Cardiac pacing and defibrillation studies
- Insects and Parasite Interactions
- Bacterial Infections and Vaccines
- Gender, Health, and Social Inequality
- Bacterial biofilms and quorum sensing
- Nuclear Structure and Function
- Spinal Cord Injury Research
- Adolescent Sexual and Reproductive Health
- Electrical and Bioimpedance Tomography
University of Arizona
2024
Lehigh Valley Hospital-Pocono
2023-2024
Lehigh Valley Health Network
2024
Shirley Ryan AbilityLab
2023
University of Wisconsin–Madison
2019-2021
University of Washington
2020
Program for Appropriate Technology in Health
2017-2020
Vanderbilt University
2016
Our current knowledge regarding microbial bile acid transformations comes primarily from biochemical studies on a relatively small number of species or bioinformatic predictions that rely homology to known acid-transforming enzyme sequences. Therefore, much remains be learned the variety and their representation across gut species.
The microbial communities that inhabit the distal gut of humans and other mammals exhibit large inter-individual variation. While host genetics is a known factor influences microbiota composition, mechanisms underlying this variation remain largely unknown. Bile acids (BAs) are hormones produced by chemically modified bacteria. BAs serve as environmental cues nutrients to microbes, but they can also have antibacterial effects. We hypothesized genetic in BA metabolism homeostasis influence...
As effective onchocerciasis control efforts in Africa transition to elimination efforts, different diagnostic tools are required support country programs. Senegal, with its long standing, successful program, is transitioning using the SD BIOLINE Onchocerciasis IgG4 (Ov16) rapid test over traditional skin snip microscopy. The aim of this study demonstrate feasibility integrating Ov16 into surveillance activities based on following attributes acceptability, usability, and cost. A...
We report aqueous emulsions of thermotropic liquid crystals (LCs) that can intercept and on the presence N-acyl-l-homoserine lactones (AHLs), a class amphiphiles used by pathogenic bacteria to regulate quorum sensing (QS), monitor population densities, initiate group activities, including biofilm formation virulence factor production. The concentration AHL required promote "bipolar" "radial" transitions in micrometer-scale droplets nematic LC 4′-pentyl-cyanobiphenyl (5CB) decreases with...
Abstract The microbial communities that inhabit the distal gut of humans and other mammals exhibit large inter-individual variation. While host genetics is a known factor influences microbiota composition, mechanisms underlying this variation remain largely unknown. Bile acids (BAs) are hormones produced by chemically modified bacteria. BAs serve as environmental cues nutrients to microbes, but they can also have antibacterial effects. We hypothesized genetic in BA metabolism homeostasis...
Abstract Onset and rates of sarcopenia, a disease characterized by loss muscle mass function with age, vary greatly between sexes. Currently, no clinical interventions successfully arrest age-related impairments since the decline is frequently multifactorial. Previously, we found that systemic transplantation our unique adult multipotent muscle-derived stem/progenitor cells (MDSPCs) isolated from young mice—but not old—extends health-span in DNA damage mouse models progeria, accelerated...
There is growing interest in studying inequitable gender norms and their impact on health wellbeing, particularly among adolescents. Studies have shown that discriminatory limit girls' access to power within families communities, reduce educational economic opportunities, alter own aspiration ambitions for lives. This comparative qualitative study sought understand how manifest themselves the lives of adolescents two distinct settings: Uganda Colombia. A total 133 young people aged 13–21...
Abstract Background Patients with chronic stimulant-induced cardiomyopathy presenting cardiogenic shock can be stabilized conventional measures. However, their management post-stabilization has not been well described and poses unique challenges: (i) less chance of myocardial recovery compared to acute cardiomyopathy, (ii) psychosocial barriers left ventricular assist device (LVAD) heart transplantation, (iii) concern for use peripherally inserted central catheter home inotrope in those a...
Following spinal cord injury (SCI), there is a short-lived recovery phase that ultimately plateaus. Understanding changes within the over time may facilitate targeted approaches to prevent and/or reverse this plateau and allow for continued recovery. Untargeted metabolomics revealed distinct metabolic profiles injured during (7 days postinjury [DPI]) (21 DPI) periods in mouse model of severe contusion SCI. Alterations lipid metabolites, particularly those involved phospholipid (PL)...
In low- and middle-income countries, many women experience anemia during pregnancy due to insufficient dietary intake of key micronutrients, parasitic infections, hemoglobinopathies, chronic infections. Maternal increases perinatal risks for both mothers infants, slow progress reduce the prevalence may be in part lack affordable tools quantify hemoglobin levels antenatal care (ANC) clinics. A simple, inexpensive, accurate, robust diagnostic is needed measure ANC. This study evaluated...
Heart disease is the leading cause of death in western world. Approximately five million people United States have congestive heart failure (CHF), with two hundred fifty thousand those most advanced stages CHF. Left ventricular assist devices (LVAD) are currently state-of-the-art treatment for patients end stage cardiac who not a candidate transplant. LVADs powered by external power sources that connect to pump via percutaneous lead (driveline). The driveline exits body, typically from right...