About
Contact & Profiles
A5040713498
Research Areas
- Alzheimer's disease research and treatments
- Microtubule and mitosis dynamics
- Mitochondrial Function and Pathology
Columbia University
2017
Oligomeric Amyloid β1–42 (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between tau, however, remains controversial. In this study, we find that hippocampal neurons, acutely induces tubulin posttranslational modifications (PTMs) stabilizes dynamic microtubules (MTs) by reducing their catastrophe frequency. Silencing or acute inhibition of the formin mDia1 suppresses these activities corrects synaptotoxicity...
10.1083/jcb.201701045
article
EN
cc-by-nc-sa
The Journal of Cell Biology
2017-09-06
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