A5086983128- Cancer Cells and Metastasis
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Foot and Ankle Surgery
- Statistical Methods in Clinical Trials
- Statistical Methods and Inference
- Lung Cancer Research Studies
- Advanced Causal Inference Techniques
- Cancer Risks and Factors
- Cancer Treatment and Pharmacology
- Diabetic Foot Ulcer Assessment and Management
- Peripheral Artery Disease Management
- Acute Myeloid Leukemia Research
- BRCA gene mutations in cancer
- Ultrasound in Clinical Applications
- Head and Neck Cancer Studies
- Patient Satisfaction in Healthcare
- Cancer Immunotherapy and Biomarkers
- Hemodynamic Monitoring and Therapy
- Genetic factors in colorectal cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer, Lipids, and Metabolism
- Engineering Education and Technology
- Colorectal Cancer Treatments and Studies
Sarepta Therapeutics (United States)
2025
Cornell University
2017-2024
Weill Cornell Medicine
2017-2024
New York Proton Center
2022
Icahn School of Medicine at Mount Sinai
2015
Mount Sinai Beth Israel
2015
New York University
2015
Albert Einstein College of Medicine
2015
Montefiore Medical Center
2015
Health Innovations (United States)
2015
Obesity, defined as a body mass index (BMI) ≥ 30, is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated BMI with germline mutation BRCA1 or BRCA2 less clear because of inconsistent findings from epidemiological studies and lack mechanistic this population. Here, we show that DNA damage normal epithelia carrying BRCA positively correlated biomarkers metabolic dysfunction. In addition, RNA sequencing showed obesity-associated...
The coronavirus disease 2019 (COVID-19) pandemic has reduced the demand for, and supply of, head neck cancer services. This study compares times to diagnosis, staging, treatment of cancers before during COVID-19 pandemic.Retrospective cohort study.Tertiary academic medical center in New York City (NYC).The for patients presenting clinics 4 oncology surgeons with newly diagnosed were compared between pre-COVID-19 periods.Sixty-eight period 26 presented cancer. Patients group had a...
One of the main challenges in drug development for rare diseases is selecting appropriate primary endpoints pivotal studies. Although many can effectively reflect clinical benefit, their sensitivity often varies, making it difficult to determine required sample size study design and interpret final results, which may be underpowered some or all endpoints. This complexity further compounded when there a desire support regulatory claims multiple dose regimens due issues multiplicity...
ABSTRACT Background Point-of-care ultrasound is an emerging technology in critical care medicine. Despite requirements for medicine fellowship programs to demonstrate knowledge and competency point-of-care ultrasound, tools guide competency-based training are lacking. Objective We describe the development validity arguments of a assessment tool ultrasound. Methods A modified Delphi method was used develop behaviorally anchored checklists 2 applications: “Perform deep venous thrombosis study...
Reconstruction of the stage II adult-acquired flatfoot deformity (AAFD) often requires use multiple osteotomies and soft tissue procedures that may not heal well in older patients. The purpose our study was to determine whether patients than 65 years with AAFD had inferior clinical outcomes or an increased number subsequent surgical after reconstruction when compared younger patients.One-hundred forty consecutive feet (70 right, 70 left) 137 were divided into 3 groups based on age: 45...
Abstract Purpose: We evaluated the prognostic and predictive value of circulating tumor cells (CTCs) hormone receptor–positive (HR+) metastatic breast cancer (MBC) patients randomized to letrozole alone or plus bevacizumab in first-line setting (CALGB 40503). Experimental Design: Blood samples were collected at pretreatment three additional time points during therapy. The presence ≥5 CTCs per 7.5 mL blood was considered CTC positive. Association with progression-free survival (PFS) overall...
Despite limited evidence, peripheral vascular disease is often cited as a contraindication for total ankle arthroplasty. The purpose of our study was to identify whether in patients undergoing arthroplasty increased the rate infection, postoperative irrigation and debridement, or failure implant.
1010 Background: Stromal tumor infiltrating lymphocyte (sTIL) quantity is prognostic in primary breast cancer, yet MBC characterized by lower sTILs. No study has definitively evaluated the association of sTIL with survival outcome metastatic (met) setting without checkpoint blockade. CALGB (Alliance) 40502 was a randomized phase 3 trial 799 pts receiving first-line chemotherapy, comparing paclitaxel, nab-paclitaxel or ixabepilone bevacizumab. We hypothesized that sTILs associated MBC....
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<div>AbstractPurpose:<p>We evaluated the prognostic and predictive value of circulating tumor cells (CTCs) hormone receptor–positive (HR<sup>+</sup>) metastatic breast cancer (MBC) patients randomized to letrozole alone or plus bevacizumab in first-line setting (CALGB 40503).</p>Experimental Design:<p>Blood samples were collected at pretreatment three additional time points during therapy. The presence ≥5 CTCs per 7.5 mL blood was considered CTC positive....
<div>AbstractPurpose:<p>We evaluated the prognostic and predictive value of circulating tumor cells (CTCs) hormone receptor–positive (HR<sup>+</sup>) metastatic breast cancer (MBC) patients randomized to letrozole alone or plus bevacizumab in first-line setting (CALGB 40503).</p>Experimental Design:<p>Blood samples were collected at pretreatment three additional time points during therapy. The presence ≥5 CTCs per 7.5 mL blood was considered CTC positive....
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e16019 Background: Most patients with advanced GI cancers lack predictive biomarkers to determine response systemic therapies. HTDS of PDTOs allows automated screening large numbers compounds identify novel therapeutic options for refractory cancer in a rapid clinically meaningful way. Our objective was the feasibility on and concordance ex-vivo sensitivity clinical establish new pipeline reveal patients. Methods: Tumor tissues were obtained from anytime during their therapies needle...
ABSTRACT Background Somatic mutations observed in clonal hematopoiesis are associated with increased age and risk of hematological malignancies. However, the limited number acute myeloid leukemia (AML) patients studies thus far has precluded determination spectrum leading to AML their impact on time diagnosis. Methods The relationship between baseline subsequent was determined a case-control study design. 212 women eventually diagnosed (median time: 9.8 years) were identified from Women’s...
We consider estimation of an optimal individualized treatment rule from observational and randomized studies when a high-dimensional vector baseline variables is available. Our optimality criterion with respect to delaying expected time occurrence event interest (e.g., death or relapse cancer). leverage semiparametric efficiency theory construct estimators desirable properties such as double robustness. propose two the rule, which arise considering loss functions aimed at (i) directly...
The expediency, possibilities and prospects of studying the basics circuit design in non-engineering specialties pedagogical university were considered. analysis modern virtualization software solutions while learning is carried out.
1049 Background: CALGB 40503 randomized HR+ MBC postmenopausal pts to Let alone or Let+Bev as first-line therapy. Adding Bev prolonged progression-free survival (PFS) but not overall (OS) (Dickler JCO 2016). We performed a correlative study assess prognostic and predictive value of CTCs in this population. Methods: Blood was collected prior initiation treatment. were enumerated using US FDA-cleared CellSearch assay; samples with ≥5 per 7.5 mLs blood considered CTC-positive (CTC+)....
Category: Ankle Arthritis Introduction/Purpose: Peripheral vascular disease (PVD) is often cited as a contraindication for total ankle replacement (TAR); however, there are no studies looking at its impact on postoperative complications. The primary purpose of our study was to identify whether preoperative PVD increased the rate infection, irrigation and debridement, or failure implant in patients undergoing arthroplasty using large dataset. Methods: PearlDiver Database used Medicare who...
Category: Other Introduction/Purpose: Aligning patient and surgeon expectations is important, as it allows for informed shared decision- making may improve postoperative satisfaction. Patient-provider communication factors have been found to affect differences between of total knee arthroplasty. Patients with limited health literacy ask fewer questions spend less time their surgeons, perceive themselves a more passive decision-making role in hand surgery clinic visits. Understanding how...
Abstract Obesity is an established risk factor for breast cancer among women in the general population after menopause. Whether elevated bodyweight a with germline mutation BRCA1 or BRCA2 less clear due to inconsistent findings from epidemiological studies and lack of mechanistic this population. Here, we show that DNA damage normal epithelium BRCA carriers positively correlated body mass index biomarkers metabolic dysfunction. Additionally, RNA-sequencing reveals significant...