A5024317355- Autism Spectrum Disorder Research
- Pharmacological Effects and Toxicity Studies
- Child Nutrition and Feeding Issues
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Attention Deficit Hyperactivity Disorder
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- Pediatric Pain Management Techniques
- Immune cells in cancer
- Circular RNAs in diseases
- Cancer, Stress, Anesthesia, and Immune Response
- Adipose Tissue and Metabolism
- Biological Activity of Diterpenoids and Biflavonoids
- Adenosine and Purinergic Signaling
- Tryptophan and brain disorders
- Sleep and Wakefulness Research
- Pediatric health and respiratory diseases
- Nerve injury and regeneration
- MicroRNA in disease regulation
- Prenatal Substance Exposure Effects
- Cancer-related cognitive impairment studies
- Sirtuins and Resveratrol in Medicine
- Hippo pathway signaling and YAP/TAZ
- Sleep and related disorders
Tehran University of Medical Sciences
2023-2025
Shahid Bahonar University of Kerman
2020-2023
Adipokines dysregulation, the main reason for cognitive impairments (CI) induced by diabetes, shows a sex-dependent pattern inherently and in response to exercise. This study aimed compare attenuating effect of 8-week high intensity-interval training (HIIT) on type 2 diabetes (T2D)-induced CI between male female rats with special focus adiponectin leptin. 28 & Wistar an average age 8 weeks were randomly assigned into four groups: control (Con), exercise (EX), Diabetes (T2D), Type + (T2D Ex)....
ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent social communication deficits and restricted, repetitive behaviours, with significant overlap in anxiety‐related symptoms. Both genetic environmental factors contribute to the development of ASD, early‐life stressors, such as maternal separation (MS), exposure neurotoxic agents, like valproic acid (VPA), being key contributors. This study investigates combined impact deprivation (MD)...
Abstract This study was designed to adjust effective chemotherapy doses of cabazitaxel (CBZ) on cognitive behaviors, inflammatory cytokines and oxidative stress parameters, survival rate in C6-induced GBM rats. Male Sprague–Dawley rats bearing intra-caudate nucleus (CN) C6 inoculation were randomly divided into nine groups as follows: sham, tumor, Temozolomide (TMZ) vehicle, TMZ, CBZ at 0.5, 1, 2 4 mg/kg. Behavioral tests rate, histopathology, immunohistochemistry, stress, evaluated. All...
IntroductionThis study was performed to evaluate the effects of low and moderate treadmill exercise for one month on social interaction, anxiety-like behaviors, spatial learning memory in male female autistic rats.MethodsPregnant rats received valproic acid (VPA) (600 mg/kg/i.p) once gestational day 12.5 induce autism-like symptoms offspring. After delivery, offspring were divided into six main groups, each with subgroups: Control (CTL, prenatal normal saline), autism (prenatal VPA),...
Abstract This study was performed to evaluate the effects of prenatal exposure pregabalin (PGB) on behavioral changes rat offspring in an animal model valproic acid (VPA)‐induced autism‐like symptoms. Pregnant rats received VPA (600 mg/kg/i.p.) once at 12.5 gestational days for symptom induction offspring. After delivery single male and female from each mother were randomly selected test (anxiety, pain response, pleasure, motor function) 60th day adulthood ( n = 7). Offspring PGB (15 &...
Autism spectrum disorders are complex behavioral that can be caused by exposure to valproic acid (VPA) during pregnancy. A therapeutic role for exercise training has been reported in many neurological diseases and problems, including autism. We aimed evaluate various intensities of endurance investigate its effects on oxidative antioxidant factors the liver young males a rat model Female rats were divided into treatment (autism) control group. The autism group received VPA intraperitoneally...
Aim: We predicted the modulation of autophagy and apoptosis in response to temozolomide (TMZ) IFN-γ based on changes expression non-coding RNAs C6-induced glioblastoma (GBM). Materials & methods: Each rat received an intraperitoneal injection TMZ (7.5 mg/kg) and/or (50,000 IU). Results: The reduced H19 colorectal neoplasia differentially expressed (CRNDE) was associated with a reduction TMZ, + therapy, whereas decreased level miR-29a (proapoptotic miRNA) increase apoptosis. Conclusion: It...
Abstract Introduction In this study, we aimed to investigate the inflammatory factors, oxidative stress, and histopathological consequences of brain‐gut axis in male female rats prenatally exposed VPA. Methods Pregnant Wistar were randomly divided into two groups. The animals received saline, valproic acid (VPA) (600 mg/kg, i.p.) on embryonic day 12.5 (E12.5). All offspring weaned postnatal 21, experiments done 60. brain intestine tissues extracted assess histopathology, inflammation,...
In the present study, we investigated effect of high-intensity interval training (HIIT) on cognitive behaviors in female rats with a high-fat diet + streptozotocin (STZ)-induced type 2 diabetes.
Cardiovascular diseases are prevalent in autistic patients. As exercise is useful the treatment of medical conditions, this study aimed to identify effect low-intensity endurance (LIEE) and moderate-intensity (MIEE) on cardiovascular events rats.Valproic acid (VPA) was administrated once gestational day 12.5 pregnant rats produce autism-like symptoms offspring. Thirty-day-old offspring were divided into 12 groups: Male-CTL, Male-VPA, Male-CTL + LIEE, MIEE, Male-VPA Female-CTL, Female-VPA,...
Background: Prenatal antiepileptic drug exposure could demonstrate both congenital malformations and behavioral impairments in offspring. Objective: This study was performed to assess the effects of prenatal pregabalin (PGB) on pain response, anxiety, motor activity some behavior adult offspring rats. Methods: Pregnant Wistar rats received PGB (7.5, 15 30 mg/kg/ip) during embryonic days 9.5- 15.5. The anxiety-like behaviors, locomotor activity, balance coordination anhedonia were examined by...