A5089105425- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Chemokine receptors and signaling
- Brain Metastases and Treatment
- Radiopharmaceutical Chemistry and Applications
- Immunotherapy and Immune Responses
- Esophageal Cancer Research and Treatment
- Microbial Inactivation Methods
- Helicobacter pylori-related gastroenterology studies
- interferon and immune responses
- Inflammatory Biomarkers in Disease Prognosis
- Transgenic Plants and Applications
- Wound Healing and Treatments
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Dermatologic Treatments and Research
- Biosensors and Analytical Detection
- Lung Cancer Research Studies
- Gastroesophageal reflux and treatments
- Immune Cell Function and Interaction
- Hedgehog Signaling Pathway Studies
- Viral Infections and Vectors
- Plant tissue culture and regeneration
- Nanoplatforms for cancer theranostics
- Retinoids in leukemia and cellular processes
University of Chicago
2021-2024
Zhangzhou Normal University
2024
Johns Hopkins University
2004-2010
Johns Hopkins Medicine
2007-2010
Johns Hopkins Bayview Medical Center
2006-2008
Abstract Purpose: Radiotherapy (RT) is a widely employed anticancer treatment. Emerging evidence suggests that RT can elicit both tumor-inhibiting and tumor-promoting immune effects. The purpose of this study to investigate suppressive factors radiotherapy. Experimental Design: We used heterologous two-tumor model in which adaptive concomitant immunity was eliminated. Results: Through analysis PD-L1 expression myeloid-derived suppressor cells (MDSC) frequencies using patient peripheral blood...
All-trans retinoic acid induces inflammatory myeloid cells to enhance antitumor adaptive immunity after radiation therapy.
Activation of TGF-β signaling serves as an extrinsic resistance mechanism that limits the potential for radiotherapy. Bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) antagonizes is implicated in cancer progression. However, molecular mechanisms BAMBI regulation immune cells its impact on antitumor immunity after radiation have not been established. Here, we show ionizing (IR) specifically reduces expression immunosuppressive myeloid-derived suppressor (MDSCs) both...
RNA N6-methyladenosine (m6A) reader YTHDF1 is implicated in cancer etiology and progression. We discovered that radiotherapy (RT) increased expression dendritic cells (DCs) of PBMCs from patients, but not other immune tested. Elevated DCs was associated with poor outcomes patients receiving RT. found loss Ythdf1 enhanced the antitumor effects ionizing radiation (IR) via increasing cross-priming capacity across multiple murine models. Mechanistically, IR upregulated through STING-IFN-I...
ABSTRACT We have previously shown that wound healing was improved in a diabetic mouse model of impaired following transfection with keratinocyte growth factor‐1 (KGF‐1) cDNA. now extend these findings to the characterization effects DNA plasmid vectors delivered rats using electroporation (EP) vivo sepsis‐based healing. To assess and healing, gWIZ luciferase PCDNA3.1/KGF‐1 expression were used, respectively. Cutaneous wounds produced an 8 mm‐punch biopsy Sprague–Dawley which by cecal...
Radiation-mediated immune suppression limits efficacy and is a barrier in cancer therapy. Radiation induces negative regulators of tumor immunity including regulatory T cells (Treg). Mechanisms underlying Treg infiltration after radiotherapy (RT) are poorly defined. Given that conventional dendritic (cDC) maintain Treg, we sought to identify target cDC signaling block radiation.
<div>AbstractPurpose:<p>Radiation-mediated immune suppression limits efficacy and is a barrier in cancer therapy. Radiation induces negative regulators of tumor immunity including regulatory T cells (Treg). Mechanisms underlying Treg infiltration after radiotherapy (RT) are poorly defined. Given that conventional dendritic (cDC) maintain Treg, we sought to identify target cDC signaling block radiation.</p>Experimental Design:<p>Transcriptomics high dimensional flow...
<p>Supplementary Figure S2. Flow cytometric characterization of tumor cDC after local radiation</p>
<p>Supplementary Figure S5. Correlation of a Human DC_Ccl22 Homolog Score and CCL22 expression among multiple TCGA cohorts</p>
<p>Supplementary Figure S7. Characterization of tumor cDC populations in Batf3-/- mice and effect αCCL22 or Treg depletion on the radiation response</p>
<p>Supplementary Figure S3. Changes in MC38 tumor cDC populations after local RT.</p>
<p>Supplementary Figure S10. αEGFR-IFNα enhances radiation efficacy in part through CD8+ T cells</p>
<p>Supplementary Figure S9. Changes in gene expression associated with ISG + cDC2 among sequencing results</p>
<p>Supplementary Figure S1. CCL22-expressing cDC are associated with worse survival in cancer patients</p>
<p>Supplementary Figure S8. Bulk RNA-sequencing of tumor myeloid cells 7 days after RT and αEGFR-IFNα</p>
<p>Supplementary Figure S4. Human expression of FOXP3 with RT and correlation a DC_Ccl22 Homolog Score among TCGA cohorts</p>