A5047433242- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Genomics and Chromatin Dynamics
- Cancer-related Molecular Pathways
- Cell death mechanisms and regulation
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Sirtuins and Resveratrol in Medicine
- Acute Myeloid Leukemia Research
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Cancer, Hypoxia, and Metabolism
- Ovarian cancer diagnosis and treatment
- Protein Degradation and Inhibitors
- Cancer Research and Treatments
- T-cell and B-cell Immunology
- Cancer Genomics and Diagnostics
- Angiogenesis and VEGF in Cancer
- Chromosomal and Genetic Variations
University of Geneva
2019-2024
UCLouvain
2015-2017
Institute of Life Sciences
2015
Centre de Biophysique Moléculaire
2015
University of Namur
2015
Summary Beyond its essential roles in ensuring faithful chromosome segregation and genomic stability, the human Smc5/6 complex acts as an antiviral factor. It binds to impedes transcription of extrachromosomal DNA templates; ability which is lost upon chromosomal integration. How distinguishes among different templates unknown. Here we show that, cells, preferentially circular rather than linear DNA. We further that this binding unlikely due differences chromatin composition. Instead,...
Abstract Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with small GTP caps at microtubule plus-ends, including those attach to kinetochores, forming kinetochore-fibres. Here we reveal kinetochore-fibres additionally contain a dynamic mixed-nucleotide zone reaches several microns in length. This becomes visible cells expressing fluorescently labelled end-binding proteins, known marker for GTP-tubulin, and endogenously-labelled HURP - protein which...
Crenolanib is a tyrosine kinase inhibitor targeting PDGFR-α, PDGFR-β and Fms related kinase-3 (FLT3) that currently evaluated in several clinical trials. Although platelet-derived growth factor receptor (PDGFR) signalling pathway believed to play an important role angiogenesis maintenance of functional vasculature, we here demonstrate direct angiostatic activity crenolanib independently PDGFR signalling. The on cell viability, migration, sprouting, apoptosis mitosis was assessed endothelial...
Following a genotoxic stress, the tumor suppressor p53 translocates to mitochondria take part in direct induction of apoptosis, via interaction with BCL-2 family members such as BAK and BAX. We determined kinetics mitochondrial translocation HCT-116 PA-1 cells exposed different stresses (doxorubicin, camptothecin, UVB). This analysis revealed an early escalation amount p53, followed by peak decrease at later time points. show that serine 20 phosphorylated form is present level during late...
Abstract Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with small GTP caps at microtubule plus-ends, including those attach to kinetochores (K-fibres). Here we reveal K-fibres additionally contain a dynamic mixed-nucleotide zone reaches several microns in length. This becomes visible cells expressing fluorescently labelled EBs, known marker for GTP-tubulin, and endogenously-labelled HURP - protein which show preferentially bind GDP lattice vitro ....