A5047792298- Genomics, phytochemicals, and oxidative stress
- Bioactive Compounds and Antitumor Agents
- Biochemical and Molecular Research
- Phytochemicals and Antioxidant Activities
- Liver physiology and pathology
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Treatments and Studies
- Phagocytosis and Immune Regulation
- FOXO transcription factor regulation
- Plant Genetic and Mutation Studies
- Glutathione Transferases and Polymorphisms
- Bioactive natural compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Redox biology and oxidative stress
- CRISPR and Genetic Engineering
- Cancer Mechanisms and Therapy
Gachon University
2020-2022
This study was focused on investigating the anticancer potential of indole-3-carbinol (I3C) against lung cancer H1299 cells via an increase in ROS levels. To investigate induction growth arrest and/or cell death cells, a cycle assay, terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labeling (TUNEL) and reactive oxygen species (ROS) detection assay were performed. Through TUNEL we detected I3C-induced DNA fragmentation. Fluorescence-activated sorting (FACS) analysis...
Acetylshikonin, a naphthoquinone, is pigment compound derived from Arnebia sp., which known for its anti‐inflammatory potential. However, anticarcinogenic effect has not been well investigated. Thus, in this study, we focused on investigating apoptotic effects against HCT‐15 and LoVo cells, are human colorectal cancer cells. MTT assay, cell counting colony formation assay have shown acetylshikonin treatment induced cytotoxic antiproliferative cells dose‐ time‐dependent manner. DNA...
Indole-3-carbinol (I3C) is a phytochemical that exhibits growth-inhibitory activity against various cancer cells. However, there are limited studies on the effects of I3C colon In this study, human colorectal carcinoma cell line (LoVo) was examined. The results 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, colony formation, and counting assays revealed suppressed proliferation LoVo Microscopy wound-healing analyses affected morphology inhibited migration cells, respectively....
Background: CRISPR/Cas9 system is a prokaryotic adaptive immune response that uses noncoding RNAs to guide the Cas9 nuclease induce site-specific DNA cleavage. Hepatocyte growth factor (HGF) well-known plays crucial role in cell and organ development. According recent studies, it has been reported HGF promoted of hepatocellular carcinoma (HCC) cells. Here, we investigated apoptotic effects HCC Methods: Crispr-HGF plasmid was constructed using GeneArt CRISPR Nuclease Vector. pMex-HGF targets...
Acetylshikonin is a shikonin derivative originated from Lithospermum erythrorhizon roots that exhibits various biological activities, including granulation tissue formation, promotion of inflammatory effects, and inhibition angiogenesis. The anticancer effect acetylshikonin was also investigated in several cancer cells; however, the against renal cell carcinoma (RCC) have not yet been studied. In this study, we aimed to investigate anticarcinogenic mechanism A498 ACHN, human RCC lines. MTT...
Abstract 6,8‐Diprenylorobol is a natural compound mainly found in Glycyrrhiza uralensis fisch and Maclura tricuspidata , which has been used traditionally as food medicine Asia. So far, the antiproliferative effect of 6,8‐diprenylorobol not studied yet colon cancer. In this study, we aimed to evaluate effects LoVo HCT15, two kinds human cancer cells. inhibited proliferation HCT15 cells dose‐ time‐dependent manner. A 40 μM for 72 h reduced both cell viability under 50%. After treatment (40 60...