A5049851195- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Bone and Joint Diseases
- Hip disorders and treatments
- Spine and Intervertebral Disc Pathology
- Bone fractures and treatments
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Knee injuries and reconstruction techniques
- Musculoskeletal pain and rehabilitation
- Spinal Fractures and Fixation Techniques
- Orthopedic Surgery and Rehabilitation
- Scoliosis diagnosis and treatment
- Hip and Femur Fractures
- Bone health and treatments
- Shoulder and Clavicle Injuries
- Bone Tissue Engineering Materials
- Hematological disorders and diagnostics
- Elbow and Forearm Trauma Treatment
- Lower Extremity Biomechanics and Pathologies
- Pelvic and Acetabular Injuries
- Sports injuries and prevention
- Diabetic Foot Ulcer Assessment and Management
- Dental Implant Techniques and Outcomes
Institut Mondor de Recherche Biomédicale
2016-2025
Paris-Est Sup
2016-2025
Assistance Publique – Hôpitaux de Paris
2015-2025
Inserm
2017-2025
Université Paris-Est Créteil
2015-2025
Centre Hospitalier Universitaire Henri-Mondor
2011-2024
Hôpitaux Universitaires Henri-Mondor
2009-2021
Centre Hospitalier Régional Universitaire de Brest
2019
Université Paris Cité
2013-2015
East–West University
2014
The infrapatellar fat pad (IFP) of the knee joint has an inflammatory phenotype in osteoarthritis (OA). Its close proximity to synovial membrane suggests that IFP could be involved induction OA synovitis. This study was undertaken investigate response fibroblast-like synoviocytes (FLS) autologous and subcutaneous adipose tissue (SCAT) from patients with severe OA.Samples IFP, SCAT, were harvested during surgery 28 end-stage OA. FLS 14 stimulated IFP- or SCAT-conditioned medium, levels...
ORTHO-1 is a European, multicentric, first in human clinical trial to prove safety and feasibility after surgical implantation of commercially available biphasic calcium phosphate bioceramic granules associated during surgery with autologous mesenchymal stromal cells expanded from bone marrow (BM-hMSC) under good manufacturing practices, patients long pseudarthrosis.Twenty-eight femur, tibia or humerus diaphyseal metaphyso-diaphyseal non-unions were recruited surgically treated France,...
<h3>Objectives</h3> Compared with subcutaneous adipose tissue (SCAT), infrapatellar fat pad (IFP), the main knee intra-articular (IAAT), has an inflammatory phenotype in patients osteoarthritis (OA). We phenotyped suprapatellar (SPFP) and hip acetabular (AFP), two other IAATs, to determinate unique signature of IAATs compared SCAT. <h3>Methods</h3> IFP, SPFP, AFP autologous SCAT were obtained from OA during total (n=38) or replacement (n=5). Fibrosis adipocyte area analysed by histology...
Abstract Short and long‐term stabilities of cementless implants are strongly determined by the interfacial load transfer between bone tissue. Stress‐shielding effects arise from shear stresses due to difference material properties implant. It remains difficult measure stress field in periprosthetic This study proposes investigate dependence tissue on (i) implant surface roughness, (ii) implant, (iii) bone‐implant contact ratio. To do so, a microscale two‐dimensional finite element model an...
Background: There is concern that regenerative cell-based therapies could result in increased risk of tumor formation. We investigated the long-term risks for systemic and site-specific cancers patients who had received autologous bone marrow-derived stromal progenitor cells to treat orthopaedic lesions. Methods: A total 1873 were treated from 1990 2006 with concentrated cells. Patients monitored cancer incidence date first operation (1990) until death, or December 31, 2011. The mean...
Obesity is associated with an increased risk of dislocation after total hip arthroplasty (THA). However, in patients obesity, it not known whether the only early postoperative period or persists several years surgery, and having bariatric surgery before undergoing THA and/or receiving a specific device (such as dual-mobility constrained acetabular liner) more effective terms decreasing dislocation.(1) What cumulative obesity absence liner, this related to component positioning? (2) Does...
THA performed in patients with cognitive deficits or neuromuscular diseases has been associated a high postoperative dislocation rate. The constrained liner reportedly provides stability recurrent dislocation. However, achieving could be offset by early loosening when used neurologic diseases.
Septic arthritis is a known complication of sickle cell disease (SCD) in children, and the association with osteomyelitis osteonecrosis has been described. However, it unclear whether this applies to adults.We therefore asked septic frequent adults SCD also associated or osteonecrosis.We retrospectively reviewed charts 2000 consecutive adult patients diagnosed recorded symptoms, select findings during physical examination, laboratory data, radiographic CT, MRI observations.Fifty-nine (3%)...
Background: Osteonecrosis of the humeral head is a frequent complication in adults with sickle cell disease. However, little known about rate of, and factors influencing, progression symptomatic shoulder osteonecrosis patients this Methods: Eighty-two adult disease (104 shoulders) were identified magnetic resonance imaging (MRI) between 1985 1993. Nineteen eighty-two homozygous for hemoglobin S (S/S genotype), thirty-seven had S/hemoglobin C (S/C), twenty-six S/beta-thalassemia (S/T)....