A5036163194- Immune responses and vaccinations
- Immunodeficiency and Autoimmune Disorders
- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Vaccine Coverage and Hesitancy
- Pediatric health and respiratory diseases
- Clinical Nutrition and Gastroenterology
- Intestinal Malrotation and Obstruction Disorders
- Food Allergy and Anaphylaxis Research
- Child Nutrition and Water Access
- Tuberculosis Research and Epidemiology
- Health Literacy and Information Accessibility
- Neonatal and fetal brain pathology
- Transplantation: Methods and Outcomes
- American Constitutional Law and Politics
- Neuroscience of respiration and sleep
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Dermatology and Skin Diseases
- Infant Health and Development
- Dietetics, Nutrition, and Education
- Diabetes and associated disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Congenital Diaphragmatic Hernia Studies
University of Southern Denmark
2016-2022
Institut Pasteur
2022
University Hospital of Geneva
2022
University of Geneva
2022
Regionshospitalet Herning
2019
Odense University Hospital
2010-2019
Kolding Hospital
2011-2019
Lillebaelt Hospital
2018
Regional Hospital West Jutland
2008
Abstract Background The bacillus Calmette-Guérin (BCG) vaccine against tuberculosis might reduce the non–tuberculosis-related child mortality rate in low-income settings. We tested hypothesis that BCG vaccination at birth would early childhood hospitalization for infection Denmark, a high-income setting. Hospitalization was secondary outcome randomized trial with primary aim to estimate potential non-specific effects of on all-cause hospitalization. Methods A total 4262 children included...
Background The BCG vaccine is administered to protect against tuberculosis, but studies suggest there may also be non-specific beneficial effects upon the infant immune system, reducing early non-targeted infections and atopic diseases. present randomised trial tested hypothesis that vaccination at birth would reduce childhood hospitalisation in Denmark, a high-income setting. Methods Pregnant women planning give three Danish hospitals were invited participate. After parental consent,...
Abstract Background Studies have suggested that Bacillus Calmette‐Guérin ( BCG ) vaccination may reduce the risk of allergic diseases, including atopic dermatitis. Methods The Danish Calmette Study was conducted 2012‐2015. Within 7 days birth new‐borns were randomised 1:1 to or no . Exclusion criteria gestational age <32 weeks, weight <1000 g, known immunodeficiency Danish‐speaking parent. Data collected through telephone interviews and clinical examinations until 13 months. Results...
To evaluate adverse reactions of the Bacillus Calmette–Guérin (BCG) Statens Serum Institut (SSI) (Danish strain 1331) used as intervention in a randomized clinical trial. A multicenter trial, The Danish Calmette Study, randomizing newborns to BCG or no intervention. Follow-up until 13 months age. Pediatric and maternity wards at three university hospitals. All women planning give birth study sites (n = 16,521) during recruitment period were invited participate study. Four thousand one...
Studies from low-income countries report positive non-specific effects of early Bacillus Calmette-Guérin (BCG) immunisation on childhood health and survival. Neonatal with BCG may prime the immune system offer partial protection against other infectious possibly allergic diseases. The potential clinical value these has not yet been examined in a large randomised trial high-income countries. Danish Calmette Study is multicentre conducted between October 2012 November 2015. Within first 7 days...
BCG vaccination has been associated with beneficial non-specific effects on child health. Some immunological studies have reported heterologous of vaccines antibody responses to vaccines. Within a randomised clinical trial Bacille Calmette-Guérin (BCG) at birth, The Danish Calmette Study, we investigated the effect birth response three routine against DiTeKiPol/Act-Hib and Prevenar 13 in subgroup participants. 7 days after children were 1:1 or control group (no intervention). After...
Abstract Background Vaccination with Bacillus Calmette‐Guérin ( BCG ) is used in many countries as protection against tuberculosis. Studies have suggested that may also non‐specific effects, reducing non‐tuberculosis mortality, morbidity, and atopic manifestations. In this study, we evaluated the effect of neonatal vaccination on allergic sensitization suspected food allergy at 13 months age. Methods The Danish Calmette Study was conducted from 2012 to 2015 three hospitals. Within 7 days...
The Bacillus Calmette-Guérin vaccine (BCG) against tuberculosis is administered intradermally, and vaccination often followed by a scar at the injection site. Among BCG-vaccinated individuals, having has been associated with lower mortality. We aimed to examine impact of technique for scarring in high income setting, assessing associations between post reaction, wheal size, probability developing scar, size. This study was nested within clinical multicenter randomizing 4262 infants either...
BackgroundRecurrent wheeze (RW) is frequent in childhood. Studies have suggested that BCG vaccination can nonspecific effects, reducing general nontuberculosis morbidity, including respiratory tract infections and atopic diseases. The mechanisms behind these effects of are not fully understood, but a shift from TH2 to TH1 response has been as possible explanation.ObjectiveWe hypothesized at birth would reduce the cumulative incidence RW during first year life.MethodsThe Danish Calmette Study...
Abstract The Bacillus Calmette–Guérin vaccine (BCG) has been associated with beneficial non-specific effects (NSEs) on infant health. Within a randomized trial the effect of neonatal BCG overall health, we investigated possible immunological impact vaccination lymphocyte subsets, determined by flow cytometry. In 118 infants blood samples were obtained 4 (±2) days post randomization to or no intervention, and at 3 13 months age. No found days. However, increased proportions effector memory...
The Bacillus Calmette–Guérin vaccine (BCG) has been associated with beneficial nonspecific effects on infant health. We aimed to examine the effect of BCG at birth thymic size and associations between output, circulating lymphocytes, risk infection, size. In infants randomized or no BCG, index (TI), thymic/weight (TWI) were measured by ultrasound age 3 mo. T cell subpopulations including CD4+ cells, CD8+ recent emigrants (RTEs) assessed flow cytometry. Infections up mo parent-reported....
Objectives To assess the non-specific effect of Bacillus Calmette-Guérin (BCG) vaccination at birth on psychomotor development. Design This is a pre-specified secondary outcome from randomised, clinical trial. Setting Maternity units and paediatric wards three university hospitals in Denmark. Participants Children born gestational age (GA) 32 weeks above. All women planning to give sites were invited during recruitment period. Out 4262 randomised children, 144 premature (GA < 37 weeks)....
Abstract Background Sensitization means elevated number of specific immunoglobulin E, either measured by skin prick test or in blood samples. is associated with, but not synonymous allergic disease. Methods The Danish Calmette Study was conducted from 2012 to 2015 at three hospitals, with the aim exploring nonspecific effects neonatal Bacillus Calmette‐Guérin vaccination. Participants Kolding Hospital were invited have a sample analyzed for sensitization 13 months age. Telephone interviews...
Objective To explore the informational needs of mothers with different levels education in order to improve counselling about vaccination. Methods In setting a large vaccination trial, mothers' assessments and yield written information combination telephone consultations were evaluated survey. Furthermore, searching strategies for additional investigated. Mothers' perspectives on explored focus group discussions. Results Out 2025 mothers, 95% felt well‐informed. Of 4% not feeling...