A5074162944- Congenital Heart Disease Studies
- Tracheal and airway disorders
- Aortic Disease and Treatment Approaches
- Cardiovascular Conditions and Treatments
- Autophagy in Disease and Therapy
- Cardiac Structural Anomalies and Repair
- Congenital Diaphragmatic Hernia Studies
- Vascular Anomalies and Treatments
- Cardiac Ischemia and Reperfusion
- Cardiac Valve Diseases and Treatments
- MicroRNA in disease regulation
- Adenosine and Purinergic Signaling
- RNA regulation and disease
- Hospital Admissions and Outcomes
- Pneumonia and Respiratory Infections
- Cardiac pacing and defibrillation studies
- Emergency and Acute Care Studies
- Mechanical Circulatory Support Devices
- Clinical practice guidelines implementation
- Congenital gastrointestinal and neural anomalies
- RNA Interference and Gene Delivery
- Circular RNAs in diseases
- Cardiovascular Issues in Pregnancy
- Cardiac tumors and thrombi
- Gastrointestinal disorders and treatments
Beijing Children’s Hospital
2017-2024
Capital Medical University
2017-2024
Center for Children
2020-2023
Peninsula Health
2013-2015
Frankston Hospital
2013
Taoyuan Armed Forces General Hospital
2006
The objective of this study was to investigate the role lncRNA XIST and its relationship with miR-133a in myocardial I/R injury. H9C2 cells treated by hypoxia/reoxygenation (H/R) were used establish an vitro model. small interfering RNA (siRNA) for miR-133 mimics, inhibitor, suppressor cytokine signaling (SOCS2) recombinant plasmids transfect cells. Cell apoptosis determined flow cytometry analysis, cell viability 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, Thiazolyl...
For many years, percutaneous interventional occlusion of congenital patent ductus arteriosus (PDA) has been completed using radiation and contrast agents. In this study, transthoracic echocardiography without agents was used to complete pediatric PDA.Thirty-two children (8 males 24 females) with normal heart function no other intracardiac deformities were diagnosed PDA (20 funnel type; 12 tube type), One patient had peripheral facial paralysis, 1 epilepsy, case multiple cervical deformities....
Abstract Aim: Preoperative pneumonia in children with CHD may lead to longer stays the ICU after surgery. However, research on associated risk factors is limited. This study aims evaluate pre-, intra-, and postoperative contributing extended these children. Methods: retrospective cohort collected data from 496 complicated by preoperative who underwent cardiac surgery following medical treatment at a single centre 2017 2022. We compared clinical outcomes of patients varying utilised...
This study was performed to analyze the surgical outcomes of our center biventricular correction with total anomalous pulmonary venous connection (TAPVC) and explore risk factors associated postoperative mortality obstruction (PVO).In total, 104 patients diagnosed TAPVC underwent from January 1, 2009 December 31, 2021, in Beijing Children's Hospital Affiliated Capital Medical University were included. The primary endpoints early late vein obstruction.Multivariable analysis indicated that...
This study aimed to explore the selection of views for transthoracic echocardiography-guided transfemoral puncture device closure pediatric atrial septal defect (ASD) without radiation.Sixty children (29 males and 31 females) were diagnosed with a central ASD, normal heart function, no other intracardiac deformity. All procedures performed in surgical operating room (without radiological equipment) under basic anesthesia; femoral vein pathway guidance by only echocardiography used complete...
Cardiac mass in children is rare and insidious onset, primary cardiac less than secondary mass. Among the malignant tumours with tumour thrombus venous system, about 98% of cases are nephroblastoma. But it still for to reach level atrium or even enter right ventricle. In this case, child complained chest tightness palpitation went doctor found Wilms complicated intracardiac thrombus.
ABSTRACT Importance Scimitar syndrome (SS) is a rare type of congenital heart disease characterized by total or partial anomalous venous drainage the right lung to inferior vena cava. However, surgical repair techniques for SS vary according patients’ anatomical and pathological features. Objective This study was performed analyze mid‐term results less invasive correction technique in children. Methods Eleven patients with who underwent from January 2012 March 2020 were retrospectively...
The purpose of this study was to evaluate our institution's 16-year arterial switch operation (ASO) experience and determine early late mortality morbidity, as well the need for reoperation catheter intervention, finally, explore risk factors complications reintervention.The clinical data 185 transposition great arteries (TGA) patients who received ASO treatment in center from January 2006 2022 were continuously included retrospective study.There 13 deaths (7.03%), 5 (3.01%), 6 lost...
Objective To explore the role of cardiac surgeons in prenatal online counselling for congenital heart disease. Methods From January 2014 to December 2017, author consulted on 400 cases foetal cardiovascular abnormalities through Good Doctor Online and WeChat platforms. The made appropriate pregnancy recommendations patients families using patient ultrasound reports medical histories. Followed-up who chose continue their received postnatal advice. Results There were 248 simple 152 complex...
Objectives The objective of this study was to evaluate the predictive value main pulmonary artery (MPA) Z score, valve annulus (PVA) prop, great aortic (GA) ratio, PVA index (PAI), and area (PAAI) indicators in patients with Tetralogy Fallot (TOF) whether or not undergo transannular patch (TAP). Methods A retrospective analysis performed on clinical data 263 TOF who underwent radical operations from 2010 2021 at Beijing Children's Hospital. Sixteen cases were excluded, 247 (male/female =...
The objective was to identify the differential expressed miRNA during cerebral ischemia–reperfusion injury (CIRI) process, thereby assisting in elucidating mechanism of CIRI development and providing a potential target for prevention treatment. Six mice were randomly assigned two groups: control group model group. A global IR by four-vessel occlusion prepared among Brain tissues collected 48 h after reperfusion. Total RNA extracted each sample. microarrays employed detect differentially...
Abstract Background: Several evidences suggested that the protective effect of hypothermia on brain injury is related to inhibition apoptosis and depends onset time degree maturation. We performed many experiments aimed comprehensively explore biological functions moderate low temperature protects ischemic in a mouse its underlying mechanism.Methods: 12 normal healthy C57BL6 were selected, model selected. The protect mechanism explore.Results: Based our results, we found protection could...
Objective To investigate the diagnosis, surgical treatment and results of infantile left subclavian artery combined with Kommerell diverticulum. Methods In our hospital from 2014 to 2017, there were 15 cases diverticulum, 10 males 5 females, average age 11.8 months(2 48 months), weight 9.2kg(4 - 24 kg), including 3 ventricular septal defect(VSD), 1 coarctation aorta(COA). Children postoperative respiratory difficulty, recurrent infection, chronic cough other symptoms, preoperative...
Abstract The authors have requested that this preprint be withdrawn due to erroneous posting.
Abstract Background To investigate the potential role of CFTR in myocardial ischemic/reperfusion (I/R) injury and its relationship with mitophagy. Methods Wild type (WT) age matched −/− male mice were used to establish I/R model. activator forskolin (FSK) was activate mice. Hypoxia/reoxygenation (H/R) treatment for vitro model WT or cardiomyocytes. The autophagy inhibitor 3-MA rapamycin inhibition activation autophagy, respectively. mitochondrial membrane (MMP) ATP concentration detected....