A5020536278- DNA Repair Mechanisms
- COVID-19 Clinical Research Studies
- Microtubule and mitosis dynamics
- COVID-19 and healthcare impacts
- CRISPR and Genetic Engineering
- Long-Term Effects of COVID-19
- Plant Genetic and Mutation Studies
- Cancer Research and Treatments
- SARS-CoV-2 and COVID-19 Research
- Library Science and Information Literacy
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Herpesvirus Infections and Treatments
- RNA Research and Splicing
- Celiac Disease Research and Management
- Carcinogens and Genotoxicity Assessment
- Inflammatory Bowel Disease
- Toxoplasma gondii Research Studies
- Aortic Disease and Treatment Approaches
- Microbial infections and disease research
- COVID-19 and Mental Health
- Microscopic Colitis
- Library Collection Development and Digital Resources
- Web and Library Services
University of Birmingham
2020-2023
University of Illinois Urbana-Champaign
1985
Despite being the first homolog of bacterial RecQ helicase to be identified in humans, function RECQL1 remains poorly characterized. Furthermore, unlike other members human RECQ family helicases, mutations have not been associated with a genetic disease. Here, we identify 2 families genome instability disorder that named RECON (RECql ONe) syndrome, caused by biallelic RECQL gene. The affected individuals had short stature, progeroid facial features, hypoplastic nose, xeroderma, and skin...
Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability cells to respond replicative stress (RS) protect forks. These responses rely on formation Replication Protein A (RPA)-single stranded (ss) DNA complexes, yet this process remains largely uncharacterized. Here, we establish that actin nucleation-promoting factors (NPFs) associate with forks, promote efficient facilitate association RPA ssDNA at sites RS. Accordingly,...
COVID-19: The heart of the issue Beth Woodward BMedSc (Hons)1, Muhammed Kermali2College Medical and Dental Sciences, University Birmingham, UKSt. George's, London, UKCorresponding author:Beth WoodwardBMedSc (Hons)College SciencesUniversity BirminghamBirmingham, UKe-mail: blw472@student.bham.ac.ukTel: 07947766140Funding: none obtainedConflict Interest: to be declaredKey words: COVID-19, angiotensin, ACEiBW MK contributed equally.
We read with great interest the review by Khan et al1 who discussed emerging role of cardiovascular disease and progression novel coronavirus 19 (COVID-19). As part their review, authors a broad range effects being observed during after infection in this disease. commend conclusions that appropriate triage risk stratification is essential patients (CVD) COVID-19. encourage need for further evidence regarding mechanisms CVD particularly use therapeutics. This particular importance given...
Abstract Accurate genome replication is essential for all life and a key mechanism of disease prevention, underpinned by the ability cells to respond replicative stress protect stalled forks. All such responses rely on formation Replication Protein A (RPA)-ssDNA complexes, yet supra-physiological binding RPA ssDNA toxic. How regulate availability promote fork protection stability largely unknown. Here we establish that during excess sequestered monomeric actin released upon through...