A5090711824- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Radiopharmaceutical Chemistry and Applications
- Gastrointestinal disorders and treatments
- Congenital Diaphragmatic Hernia Studies
- Nutrition and Health in Aging
- Lymphatic Disorders and Treatments
- MRI in cancer diagnosis
University Medical Center Utrecht
2018-2024
Heidelberg University
2018-2023
University Hospital Heidelberg
2018-2023
Utrecht University
2018-2023
Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) the primary tumor upon histopathological evaluation resection specimen. The aim this study is to develop model that predicts probability pCR nCRT in cancer, based on diffusion-weighted magnetic resonance imaging (DW-MRI), dynamic contrast-enhanced (DCE-MRI) and 18F-fluorodeoxyglucose positron emission tomography with computed (18F-FDG...
Abstract Background In cT4b esophageal cancer, accurate assessment of tracheobronchial tree invasion after definitive chemoradiotherapy (dCRT) aids in the selection patients for whom an oncologic radical esophagectomy can be achieved. The current report aimed to determine accuracy endobronchial ultrasound assessing tumor dCRT with cancer. Methods Esophageal cancer suspicion on diagnostic contrast-enhanced computed tomography (CT) who underwent a staging ultrasonography (EBUS) were eligible...
Abstract Background Patients with esophageal cancer that invades adjacent structures (cT4b) are precluded from surgery and usually treated definitive chemoradiotherapy (dCRT). dCRT might result in sufficient downstaging to enable a radical resection, possibly improving survival. This study aimed assess the perioperative oncologic outcomes of salvage robot-assisted minimally invasive esophagectomy (RAMIE) patients cT4b after dCRT. Methods Between June 2012 November 2019, who underwent RAMIE...
Background: Neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer causes tumor regression during treatment. Tumor can induce changes in the thoracic anatomy, with smaller target volumes and displacement of organs at risk (OARs) surrounding as a result. Adaptation radiotherapy treatment plan according to volumetric might reduce radiation dose OARs, while maintaining adequate coverage. Data on magnitude its impact anatomy is scarce. The aim this study was assess primary nCRT based weekly...
BackgroundThe thoracic lymphadenectomy during an esophagectomy for esophageal cancer includes resection of the duct (TD) compartment containing TD lymph nodes (TDLNs). The role is still a topic debate since metastatic TDLNs have only been demonstrated in squamous cell carcinomas Eastern patients. Therefore, aim this study was to assess presence and involvement Western population, which adenocarcinoma predominant type cancer.MethodsFrom July 2017 May 2020, all consecutive patients undergoing...
PurposeThis study aimed to assess the smallest clinical target volume (CTV) planned (PTV) margins for esophageal cancer radiotherapy using daily online registration bony anatomy that yield full dosimetric coverage over course of treatment.Methods29 patients underwent six T2-weighted MRI scans at weekly intervals. An bone-match image-guided treatment five fractions was simulated each patient. Multiple conformal plans with increasing around CTV were created Then, dose warped obtain an...
Diffusion weighted magnetic resonance imaging (DW-MRI) can be prognostic for response to neoadjuvant chemotherapy (nCRT) in patients with esophageal cancer. However, manual tumor delineation is labor intensive and subjective. Furthermore, noise DW-MRI images will propagate into the corresponding apparent diffusion coefficient (ADC) signal. In this study a workflow investigated that combines denoising algorithm semi-automatic segmentation quantifying ADC changes.Twenty cancer who underwent...
To identify risk factors for tumor positive resection margins after neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy esophageal cancer.Esophagectomy nCRT is associated with in 4% to 9% of patients. This study evaluates potential esophagectomy.All patients who underwent an elective following 2011 2017 the Netherlands were included. A multivariable logistic regression was performed assess association between and margins.In total, 3900 Tumor observed 150 (4%) Risk included length...
The aim of this study was to assess body composition and physical strength changes during neoadjuvant chemoradiotherapy (nCRT) their predictive value for (severe) postoperative complications overall survival in patients who underwent oesophagectomy oesophageal cancer.Consecutive nCRT with curative intent a tertiary referral center were included the study. Perioperative data collected prospectively maintained database. CT images before after used skeletal muscle index (SMI), subcutaneous fat...
Abstract Aim To assess changes in tumor volume during neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer with weekly MRI. Background & Methods Neoadjuvant can cause regression, however data on the magnitude of volumetric nCRT are scarce. Tumor regression induce thoracic anatomy, smaller target volumes and displacement organs at risk (OARs) close proximity to as a result. Adaptation radiotherapy treatment plan according might reduce dose OARs while maintaining adequate coverage....