A5030196022- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Maternal Mental Health During Pregnancy and Postpartum
- Digital Mental Health Interventions
- Treatment of Major Depression
- Behavioral Health and Interventions
- Neuroendocrine regulation and behavior
- HIV, Drug Use, Sexual Risk
- Prenatal Substance Exposure Effects
- Mental Health Treatment and Access
- Homelessness and Social Issues
- Impact of Technology on Adolescents
- Cannabis and Cannabinoid Research
- Stress Responses and Cortisol
- HIV/AIDS Research and Interventions
- Smoking Behavior and Cessation
- Menopause: Health Impacts and Treatments
- Circadian rhythm and melatonin
- Social Media in Health Education
- Mental Health and Patient Involvement
- Schizophrenia research and treatment
- Mind wandering and attention
- Pharmaceutical industry and healthcare
Johns Hopkins University
2015-2024
Johns Hopkins Bayview Medical Center
2017-2024
Johns Hopkins Medicine
2015-2023
Medpace (United States)
2023
Behavioral Pharma (United States)
2019-2020
Janssen (Belgium)
2013
University of Toronto
2013
Vanderbilt University
2013
Duke University
2013
United States Department of Veterans Affairs
2013
Background and Objectives Individuals exposed to fentanyl are at risk of precipitated withdrawal using typical buprenorphine/naloxone induction procedures. Methods This case series describes inductions four individuals who tested positive for fentanyl. Results Buprenorphine‐precipitated was observed in two completed a conventional strategy. Two more revised strategy that did not precipitate withdrawal. Discussion Conclusion Using multiple 2 mg doses patients already mild/moderate improved...
Increased orexin/hypocretin signaling is implicated in opioid withdrawal, sleep disturbances, and drug-seeking behaviors. This study examined whether a dual-orexin receptor antagonist would improve withdrawal outcomes when compared with placebo during buprenorphine/naloxone taper. Thirty-eight participants use disorder were recruited to clinical research unit maintained on 8/2 16/4 mg of treatment for 3 days before being randomized 20 suvorexant ( n = 14), 40 12), or 12); 26 individuals...
We previously discovered a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 5 (mGlu(5)) termed 4 N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) that elicits activation through novel site on mGlu(5), distinct from classical mGlu(5) negative (NAM) MPEP site. However, shallow structure-activity relationship (SAR), poor physiochemical properties, and weak PAM activity at rat limited utility CPPHA to explore...
Intact female rats and ovariectomized (OVX) with different ovarian steroid replacement regimens were tested for changes in corticotropin-releasing factor (CRF)-enhanced startle (increased acoustic amplitude after intracerebroventricular infusion of 1 μg CRF). OVX injected estradiol (E) followed by progesterone (P) showed a blunted CRF-enhanced effect compared E-injected rats. also was reduced significantly lactating females (high endogenous P levels) cycling (low to moderate levels), as well...
Impaired transmission through glutamatergic circuits has been postulated to play a role in the underlying pathophysiology of schizophrenia. Furthermore, inhibition <i>N</i>-methyl-d-aspartate (NMDA) subtype ionotropic glutamate receptors (NMDAR) induces syndrome that recapitulates many symptoms observed patients with Selective activation metabotropic receptor 5 (mGlu<sub>5</sub>) may provide novel therapeutic approach for treatment associated schizophrenia facilitation central circuits....
Increased acoustic startle in the presence of bright ambient light, a phenomenon called light-enhanced (LES), is dependent on bed nucleus stria terminalis. In contrast to gonadally intact male rats, LES was seen reliably castrated rats and female although it fluctuated significantly with reproductive state. Replacement testosterone (T) or combined estradiol (E2) dihydrotestosterone (DHT), but not either E2 DHT alone, attenuated rats. However, replacement T ovariectomized did decrease LES....
Abstract An iterative analogue library synthesis strategy rapidly developed comprehensive SAR for the mGluR5 ago‐potentiator ADX‐47273. This effort identified key substituents in 3‐position of oxadiazole that engendered either ago‐potentiation or pure positive allosteric modulation. The modulators possessed largest fold shifts (up to 27.9‐fold) glutamate CRC reported date as well providing improved physiochemical properties. magnified image
Interventions are needed to improve viral suppression rates among persons with HIV and substance use. A 3-arm randomized multi-site study (Metsch et al. in JAMA 316:156–70, 2016) was conducted evaluate the effect on outcomes of usual care referral use services (N = 253) versus patient navigation delivered alone (PN: N 266) or together contingency management (PN + CM; 271) that provided financial incentives targeting potential behavioral mediators load suppression. This secondary analysis...
This secondary analysis compares health behavior outcomes for two groups of HIV+ substance users randomized in a 3-arm trial [1] to receive Patient Navigation with (PN+CM) or without (PN) contingent financial incentives (CM). Mean age participants was 45 years; the majority male (67%), African American (78%), unemployed (35%), disabled (50%). Behaviors incentivized PN+CM were (1) attendance at HIV care visits and (2) verification an active medication prescription. Incentives associated...
Objectives: There has been advocacy for legalization of abusable substances, but systematic data on societal beliefs regarding such are limited. People who use substances may have unique about legalization, and this study assessed whether they would be in favor drug legalization/decriminalization. It was hypothesized that those particular drugs (especially marijuana) support its legalization/decriminalization, not the case across all classes opioids stimulants). Methods: A nationwide sample...
Objectives Technology-assisted treatment (TAT) holds promise for innovative assessment, prevention, and of substance use disorders (SUD). The widespread access to TAT makes it a potentially cost-effective inventive option available delivery in multiple settings. This study assessed acceptability the web-based Therapeutic Education System (TES) hospitalized dual diagnosis patients with SUDs other psychiatric disorders. Methods: Eligible participants were nonpsychotic, voluntary self-reported...
Substance use is a major issue for adolescents and young adults, particularly college students. With the importance of peer influence ubiquitous social media among these age groups, it important to assess what discussed on various sites regarding substance use. One particular mobile app (Yik Yak) allowed users post any message anonymously nearby persons, often in areas with close proximity colleges universities.This study describes content, including attitude toward substances, discussions...
Background Perinatal women treated for substance use disorder (SUD) face considerable barriers to recovery that might be ameliorated through activation of community support.
Background: Pregnant women with substance use disorder often fail to complete treatment. Treatment retention can be influenced by many factors, including CPS involvement. This study evaluates the relationship, if any, between active involvement while in treatment and outcomes. Methods: is a retrospective analysis of data from 127 patients Center for Addiction Pregnancy at Johns Hopkins Bayview Medical Baltimore, MD. The sample included 92 cases 35 individuals without current A log binomial...
Drug legalization and decriminalization policy has changed in recent years. This study examined attitudes regarding drug among persons who use substances, a perspective that can provide unique view on legalization/decriminalization. A nationwide sample of 515 adults with without substance were surveyed online to assess opinions decriminalization. Legalization/decriminalization beliefs rated an 11-point scale (0, “strongly disagree”; 10, agree”) compared across demographic characteristics....
Objective: This study evaluated the presence of drug-free family and friends in social networks patients treated an inpatient setting for co-occurring psychiatric disorders substance use problems. Methods: Social network interviews were conducted with inpatients at Johns Hopkins Bayview Acute Psychiatric Unit problems (N = 90). Results: Participants reported about five members, which four drug-free. Most participants (> 70%) willing to include a person current treatment plan support recovery...
<sec> <title>BACKGROUND</title> Substance use is a major issue for adolescents and young adults, particularly college students. With the importance of peer influence ubiquitous social media among these age groups, it important to assess what discussed on various sites regarding substance use. One particular mobile app (Yik Yak) allowed users post any message anonymously nearby persons, often in areas with close proximity colleges universities. </sec> <title>OBJECTIVE</title> This study...