A5052676074- Renal Diseases and Glomerulopathies
- Pregnancy and Medication Impact
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and preeclampsia studies
- Systemic Lupus Erythematosus Research
- Vasculitis and related conditions
- COVID-19 Clinical Research Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Sepsis Diagnosis and Treatment
- Acute Kidney Injury Research
- Renal Transplantation Outcomes and Treatments
- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Autoimmune Bullous Skin Diseases
- Systemic Sclerosis and Related Diseases
- Renal and Vascular Pathologies
- Pediatric Urology and Nephrology Studies
- Genetic Syndromes and Imprinting
- Central Venous Catheters and Hemodialysis
- Genetic and Kidney Cyst Diseases
- Pharmacological Effects and Toxicity Studies
- Complement system in diseases
- Kidney Stones and Urolithiasis Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Neurology and Historical Studies
Centro Hospitalar Lisboa Norte
2015-2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Hospital de Santa Maria
2015-2023
Municipal de Óbidos
2017
Vanderbilt University Medical Center
2017
Instituto Português de Oncologia Francisco Gentil
2013
Using the Risk, Injury, Failure, Loss of kidney function, End-stage disease (RIFLE), Acute Kidney Injury Network (AKIN) and Disease: Improving Global Outcomes (KDIGO) systems, incidence acute injury (AKI) their ability to predict in-hospital mortality in severe sepsis or septic shock was compared.We performed a retrospective analysis 457 critically ill patients with hospitalized between January 2008 December 2014. Multivariate logistic regression employed evaluate association RIFLE, AKIN...
Although the prognostic effect of obesity has been studied in critically ill patients its impact on outcomes septic and role as a risk factor for acute kidney injury (AKI) is not consensual. We aimed to analyze occurrence AKI in-hospital mortality cohort patients. This study retrospective including 456 adult with sepsis admitted Division Intensive Medicine Centro Hospitalar Lisboa Norte (Lisbon, Portugal) between January 2008 December 2014. Obesity was defined body mass index 30 kg/m2 or...
Granting the association of lactates with mortality has been largely documented in critically ill patients sepsis, its development acute kidney injury (AKI) this setting is not well established. We aimed to analyze serum at intensive care unit (ICU) admission occurrence AKI a cohort septic patients. Materials and methods: This study retrospective including 457 adult sepsis admitted Division Intensive Medicine Centro Hospitalar Lisboa Norte (Lisbon, Portugal) between January 2008 December...
Background: Patients on hemodialysis (HD) are at higher risk for COVID-19, overall poor responders to vaccines, and were prioritized in the Portuguese vaccination campaign. Objective: This work aimed evaluating HD patients immunogenicity of BTN162b2 after two doses induction phase, persistence specific antibodies along time, factors predicting these outcomes. Methods: We performed a prospective, 6-month long longitudinal cohort analysis 156 scheduled receive BTN162b2. ELISA quantified...
Intra-atrial catheter (IAC) placement through an open surgical approach has emerged as a life-saving technique in hemodialysis (HD) patients with vascular access exhaustion.To assess the complications of IAC placement, well patient and survival after this procedure.The authors retrospectively analyzed all seven capital exhaustion, without immediate alternative renal replacement therapy (RRT), who underwent between January 2004 December 2015 at single center.Seven were submitted to twelve...
Background: In glomerular disease, the degree of proteinuria is closely related to progression chronic kidney and its reduction associated with a slower decline in filtration rate (eGFR) consequent improvement renal prognosis. The aim this study was evaluate impact on eGFR patients during first year after diagnosis. Methods: This retrospective analysis primary followed at Nephrology Department Centro Hospitalar Universitário Lisboa Norte, 2019. We analyzed demographic, clinical laboratorial...
Abstract Background and Aims Rituximab (RTX) has been reported as an effective treatment alternative in primary forms of minimal change disease (MCD) focal segmental glomerulosclerosis (FSGS) associated with steroid dependence frequent relapses. However, the optimal RTX regimen outcomes further doses remain unclear. This study aimed to evaluate use induction maintenance therapy for adults podocytopathies. Method We performed a retrospective case series on adult patients steroid-dependent...
Hemophagocytic syndrome (HPS) is a rare, aggressive disorder characterized by dysregulation of lymphocyte and macrophage activity, which culminates in tissue infiltration with hemophagocytosis ultimately organ failure. Renal involvement frequently ensues usually results acute tubular necrosis associated interstitial inflammation. Less frequently, glomerulopathy can also be found.We report case 24-year-old Caucasian woman previous asymptomatic hematuria, mild proteinuria, normal renal...
Deafness, kidney disease and diabetes are not a usual association, neither is family history of these diseases. We present the case 47-year-old woman with non-nephrotic proteinuria, no haematuria, normal renal function, sensorineural hearing loss, recently diagnosed maculopathy. There was maternal deafness, disease. Renal biopsy revealed focal segmental glomerulosclerosis (FSGS), leading to pursuit an m.3243A > G mitochondrial mutation diagnosis maternally inherited deafness. The association...
ABSTRACT Background Hemodialyzed patients are at higher risk for COVID-19 and were prioritized in the Portuguese vaccination campaign Methods We performed a prospective, longitudinal, cohort analysis of 143 on hemodialysis age-matched controls along BTN162b2 vaccination. ELISA quantified anti-full-length Spike IgG, IgM IgA levels prior to first vaccine dose (t0); 3 weeks later (second dose, t1); (t2); 127 re-evaluated140 (t3) 180 days (t4) after dose. Results Seroconversion t1 was remarkably...
Chronic kidney disease (CKD) commonly evolves with disturbances in mineral and bone metabolism, currently defined as CKD-MBD. Management strategies have progressed over the years, but our knowledge regarding evaluation treatment is still sparse. Herein, we describe a rare case of hemodialysis patient apparently fairly controlled hyperparathyroidism (HPTH), who developed multiple symptomatic brown tumors involving scull, mandible, vertebrae, pelvis, metacarpus. Parathyroidectomy allowed...
Abstract Background and Aims Acute kidney injury is a common complication in patients hospitalized with COVID-19, has multiple aetiologies, usually multifactorial. We present two cases of anti-glomerular basement membrane (anti-GBM) disease diagnosed after SARS-CoV-2 infection, suggesting causal correlation. Case Reports A 76-year-old female, chronic (serum creatinine 1.5mg/dL), hypertension, weight loss (16 Kg/6 months) pancreatic nodule under surveillance, presented to the emergency...
Abstract Background and Aims Genetic kidney diseases (GKD) are rarely seen in pregnancy some diagnosis will only be made during gestation, due to a high proportion of chronic (CKD) unknown etiology recent advances genetic testing. counseling and, when possible, preimplantation testing (PGT) should offered pre-pregnancy this specific CKD population. Method Retrospective analysis maternal, obstetric perinatal outcomes pregnant women with GKD surveilled at Hospital Santa Maria, the...
Abstract Background and Aims Congenital abnormalities of the urinary tract (CAKUT) represent a broad range disorders that occur due to abnormal kidney development. Maternal, obstetric, perinatal outcome in pregnant woman with CAKUT have not been extensively evaluated, although small series report an increased incidence infections (UTI) obstructive uropathy. Method Retrospective analysis maternal, outcomes patients (including genetic cystic disease) were surveilled our tertiary center by...
Abstract Background and Aims Amyloidosis is a disease caused by the extracellular deposition of amyloid material that leads to organ dysfunction. Renal involvement frequent characterized fibrils pathologic in glomeruli, vessels interstitium. The most common presentation nephrotic-range proteinuria or nephrotic syndrome can progress end stage kidney (ESKD). Prognosis usually poor, especially with cardiac severe renal requires replacement therapy. goal this study was analyse outcomes patients...
Abstract Background and Aims Chronic Kidney disease (CKD) has long been recognized as a risk factor for adverse pregnancy outcomes. Advanced CKD is also associated with decrease fertility, raising the importance of an early approach pre- menopausal women to discuss planning avoid term kidney function deterioration or prematurity sequelae in their child-to-be. Method Retrospective analysis maternal, obstetric perinatal outcomes patients stage 3 5, followed by Nephro-obstetric clinical team...
Abstract Background and Aims Pregnant patients with systemic lupus erythematosus (SLE) nephritis (LN) are at particular risk for unfavourable maternal, obstetric perinatal outcomes, especially if the disease is active. Thus, it of paramount importance that LN have preconceptional counseling in order to optimize care define best moment conceive. Method Observational retrospective study based on review medical records pregnant women surveilled our multidisciplinary maternal-fetal clinic from...
Rituximab (RTX) has been reported as an effective treatment alternative in primary forms of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) associated with steroid dependence frequent relapses. However, the optimal RTX regimen outcomes further doses remain unclear. This study aimed to evaluate use induction maintenance therapy for adults podocytopathies.
When the frontal lobe of brain is affected important behavioral changes may occur mainly at level executive functioning, i.e., planning, decision-making, judgment and self-perception. However, be different nature with marked indifference apathy. We report a clinical case an 81-year-old patient sudden onset that were initially interpreted as acute confusional episode infectious etiology, but actually they due to ischemic lesion in lobe.