A5048631342- Hereditary Neurological Disorders
- Curcumin's Biomedical Applications
- Nerve injury and regeneration
- Signaling Pathways in Disease
- Neurological diseases and metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Healthcare and Venom Research
- Cellular Mechanics and Interactions
Université de Limoges
2020-2024
Curcumin has been shown to exert beneficial effects in peripheral neuropathies. Despite its known biological activities, curcumin unfavorable pharmacokinetics. Its instability linked failure clinical trials of for the treatment human pathologies. For this reason, we developed curcumin-loaded cyclodextrin/cellulose nanocrystals (NanoCur) improve The present study aims assess potency a low dose NanoCur 2 Charcot-Marie-Tooth disease type 1A (CMT1A) rodent models at different stages disease....
The sensorimotor and histological aspects of peripheral neuropathies were already studied by our team in two rat models: the sciatic nerve crush Charcot-Marie-Tooth-1A disease. In this study, we sought to highlight compare protein signature these pathological situations. Indeed, identification profiles diseases can play an important role development pharmacological targets. fact, rats develop motor impairments that are more severe hind limbs. Therefore, for first time, expression was...
Abstract Curcumin was shown to exert beneficial effects on nerve function in peripheral neuropathies. Despite its prominent biological activities, curcumin presents with unfavorable pharmacokinetics. For this purpose, we have developed curcumin-loaded cyclodextrin/cellulose nanocrystals (NanoCur) bypass limitation. The current study aims assess the potency of NanoCur Charcot-Marie-Tooth disease type 1A (CMT1A) rodent models and compare efficacy Theracurmin® (Thera), a commercially available...