A5101501116- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Gastric Cancer Management and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Metastasis and carcinoma case studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Congenital Diaphragmatic Hernia Studies
- RNA Interference and Gene Delivery
- Neonatal Respiratory Health Research
- Periodontal Regeneration and Treatments
- CAR-T cell therapy research
- Long-Term Effects of COVID-19
- Vascular Tumors and Angiosarcomas
- Neuroendocrine Tumor Research Advances
- Genetic and Kidney Cyst Diseases
- Assisted Reproductive Technology and Twin Pregnancy
- HER2/EGFR in Cancer Research
- Occupational and environmental lung diseases
- Reproductive Biology and Fertility
- Esophageal Cancer Research and Treatment
- Oral health in cancer treatment
- Click Chemistry and Applications
Beike Biotechnology (China)
2020-2024
Shanghai Institute of Hematology
2024
Renji Hospital
2024
Shanghai Jiao Tong University
2024
Nanxi Mountain Hospital
2023
Jiangyin People's Hospital
2019-2021
Weatherford College
2021
Kelun Group (China)
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2017
Sichuan University
2013
1049 Background: HER2 is an effective therapeutic target for breast and gastric cancer. A166 antibody-drug conjugate composed of a novel cytotoxic drug site-specifically conjugated to transtuzumab sequence via stable protease-cleavable valine citrulline linker. Methods: This was single arm, open-label, multicenter, dose escalating Phase 1 first-in-human study as monotherapy in solid tumor patients. Dose escalation MTD identification directed using Bayesian logistic regression model with...
Background:The prognosis of early cardia cancer and non-cardia is still controversial.It difficult to collect a large number cases with complete information in clinical practice.Our study was aimed identify the differences clinicopathological characteristics outcomes gastric cancer.Methods: All analyzed were from Surveillance, Epidemiology, End Results database.The data patients 2004 2010 retrospectively analyzed.Patients distributed group group.Univariate multivariate analyses performed...
Abstract Background Pulmonary fibrosis (PF) is a growing clinical problem with limited therapeutic options. Human umbilical cord mesenchymal stromal cell (hucMSC) therapy being investigated in trials for the treatment of PF patients. However, little known about underlying molecular and cellular mechanisms hucMSC on PF. In this study, behavior was bleomycin-induced mouse model. Methods The effect hucMSCs lung regeneration determined by detecting Ki67 expression EdU incorporation alveolar type...
This study aimed to investigate the clinicopathological features and survival outcomes of neuroendocrine prostate cancer (NEPC).Within Surveillance, Epidemiology, End Results (SEER) database National Cancer Institute, we identified a total 510 patients with NEPC between 2006 2015. Age-adjusted incidence rates were evaluated in by SEER∗Stat Software version 8.3.6. Kaplan-Meier analysed assessed overall (OS) after stratification according marital status, age, histologic subtype, metastatic...
Abstract Coronavirus disease 2019 (COVID-19) treatments are still urgently needed for critically and severely ill patients. Human umbilical cord-mesenchymal stem cells (hUC-MSCs) infusion has therapeutic benefits in COVID-19 patients; however, uncertain efficacy been reported severe In this study, we selected an appropriate cytokine, IL-18, based on the special cytokine expression profile pneumonia of mice induced by H1N1virus to prime hUC-MSCs vitro improve effect vivo. vitro, demonstrated...
Aim: This study explored whether chemotherapy combined with palliative surgery and/or radiotherapy is a possible treatment for metastatic gastric cancer. Materials & methods: Patients were divided into groups according to treatments. COX models used explore prognostic factors. Kaplan–Meier and log-rank tests analyze outcomes. Outcomes analyzed before after propensity score matching. Results: Chemotherapy gastrectomy or metastasectomy prolongs the survival time compared alone (p < 0.05). plus...
Abstract 5‐Fluorouracil (5‐FU) has broadly been applied to treat colorectal cancer as one of the most effective chemotherapeutic agents. However, it frequently causes intestinal mucosal injury and related side effects, such abdominal pain diarrhoea, which limit use 5‐FU in a clinic setting. Polaprezinc gradually become known protective agent for management gastric ulcer. This study aimed investigate prophylactic efficacy administered orally against mucositis induced by mice on condition that...
Abstract Background Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) hold great therapeutic potential in regenerative medicine. Therefore, it is crucial to establish a Good Manufacturing Practice (GMP)-compliant methodology for the isolation and culture of WJ-MSCs. Through comprehensive research, encompassing laboratory-scale experiments pilot-scale studies, we aimed develop standardized protocols ensuring high yield quality WJ-MSCs manufacturing. Methods Firstly, optimization...
BACKGROUND The relationship between autoimmune gastritis (AIG) and gastric polyps (GPs) is not well understood. AIM To explore the clinical characteristics risk factors of AIG with GPs in patients. METHODS This double center retrospective study included 530 patients diagnosed from July 2019 to 2023. We collected clinical, biochemical, serological, demographic data were each patient. Logistic regression analyses, both multivariate univariate, conducted pinpoint independent for Receiver...
Mesenchymal stromal cells (MSCs) show potential for treating preclinical models of newborn bronchopulmonary dysplasia (BPD), but studies their therapeutic effectiveness have had mixed results, in part due to the use different media supplements MSCs expansion vitro. The current study sought identify an optimal culture supplement umbilical cord-derived (UC-MSCs) BPD therapy. In this study, we found that UC-MSCs cultured with human platelet lysate (hPL-UCMSCs) were maintained a small size from...
Abstract Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs well known by their feature of self-renewal and differentiation potential. NESTIN is cytoskeletal protein expressed MSC that functions directly cell proliferation differentiation. Here, we demonstrated adding UltraGRO, medium supplement, could maintain partially recover the expression human umbilical cord derived (UC-MSCs). Furthermore, UC-MSCs cultured with UltraGRO showed better...
<title>Abstract</title> Background Wharton's jelly derived mesenchymal stem cells (UC-MSCs) hold great therapeutic potential in regenerative medicine. However, GMP-compliant optimal methods for isolating UC-MSCs from UC tissue are still lacking. Additionally, there is a dearth of detailed research spanning laboratory-scale to pilot-scale studies. Therefore, it essential establish standardized protocols that ensure the reproducibility and safety UC-MSC manufacturing. Methods In this study, we...
Abstract Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. MSCs well known by their feature of self-renewal and differentiation potential. NESTIN is cytoskeletal protein expressed MSC that functions directly cell proliferation differentiation. Here, we demonstrated adding UltraGRO, medium supplement, could maintain partially recover the expression human umbilical cord derived (UC-MSCs). Furthermore, UC-MSCs cultured with UltraGRO showed better...
Abstract Mesenchymal stem cells (MSC) are a popular candidate in cellular therapy for many diseases. It is well known by its feature of self-renewal and differentiation potential. NESTIN cytoskeletal protein that expresses MSC plays an important role cell proliferation differentiation. Here, we demonstrated adding UltraGRO, which medium supplement, could maintain partially recover the expression human umbilical cord derived MSCs (UC-MSCs). Furthermore, UC-MSCs cultured with UltraGRO showed...
Background: Coronavirus disease 2019 (COVID-19) treatments are still urgently needed for critically and severely ill patients. Human umbilical cord-mesenchymal stem cells (hUC-MSCs) infusion has therapeutic benefits in COVID-19 patients; however, uncertain efficacy been reported severe Here, we investigated the effects of IL-18 to prime hUC-MSCs treatment pneumonia.Methods: We selected an appropriate cytokine, IL-18, based on special cytokine expression profile pneumonia mice induced by...
Abstract Coronavirus disease 2019 (COVID-19) treatments are still urgently needed for critically and severely ill patients. Human umbilical cord-mesenchymal stem cells (hUC-MSCs) infusion has therapeutic benefits in COVID-19 patients; however, uncertain efficacy been reported severe In this study, we selected an appropriate cytokine, IL-18, based on the special cytokine expression profile pneumonia of mice induced by H1N1virus to prime hUC-MSCs vitro improve effect vivo . , demonstrated that...
To explore and design a novel bi-specific chimeric antigen receptor (CAR) structure. obtain the corresponding CAR-T cells verify killing effects on tumor in vitro vivo.Five kinds of CAR structures including humanized CD19 scFv CD79b scFv, CD8 hinge & TM-4-1BB-CD3ζ and/or CD3ε chain intracellular regions were constructed prepared. CAR-19-79b obtained. Five co-incubated with 3M-CD19-CD79b-Luc target cells. Luciferase assay ELISA used to detecte ability these five groups secretion cytokines...